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Immunogen sequence: KHLSTHEAGS ARALAPGFGS ERGAPLAFAC PLCGAHFPTA DIREKHRLWH AVREELLLPA LAGAPPETSG PSGPSDGSAQ QIFSCKHCPS TF
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 84%.
IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: INSM2 variant 1; insulinoma-associated 2; Insulinoma-associated protein 2; insulinoma-associated protein IA-6; Zinc finger protein IA-6
Gene Aliases: IA-6; IA6; INSM2; mlt1; Nbla106
UniProt ID: (Human) Q96T92
Entrez Gene ID: (Human) 84684
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