Proteintech

IBA1 Monoclonal Antibody (1C6A10)

IBA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IBA1 Antibody (66827-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human tonsilitis tissue slide using 66827-1-Ig (IBA1 antibody) at dilution of 1:1000 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

66827-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:4,000

Immunocytochemistry (ICC/IF)

View 15 publications 15 publications

Flow Cytometry (Flow)

0.2 µg

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1C6A10

Immunogen

IBA1 Fusion Protein Ag28236

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

AIF1 is induced by cytokines and interferon. It is thought to be involved in the negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway.

Biochemical and biophysical research communications

Peng Z,Li XJ,Pang C,Zhang JT,Zhu Q,Sun JQ,Wang J,Cao BQ,Zhang YH,Lu Y,Li W,Hang CH,Zhuang Z

Fri Jun 30 00:00:00 EDT 2023

Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage.

Cells

Gai C,Zhao Y,Xin D,Li T,Cheng Y,Jiang Z,Song Y,Liu D,Wang Z

Thu Mar 09 00:00:00 EST 2023

ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics.

Acta neuropathologica communications

Panahi M,Hase Y,Gallart-Palau X,Mitra S,Watanabe A,Low RC,Yamamoto Y,Sepulveda-Falla D,Hainsworth AH,Ihara M,Sze SK,Viitanen M,Behbahani H,Kalaria RN

Mon May 08 00:00:00 EDT 2023

Effects of magnetically targeted iron oxide@polydopamine-labeled human umbilical cord mesenchymal stem cells in cerebral infarction in mice.

Aging

Yan J,Liu T,Li Y,Zhang J,Shi B,Zhang F,Hou X,Zhang X,Cui W,Li J,Yao H,Li X,Gao Y,Jiang J

Tue Feb 28 00:00:00 EST 2023

Effects of magnetically targeted iron oxide@polydopamine-labeled human umbilical cord mesenchymal stem cells in cerebral infarction in mice.

Aging

Yan J,Liu T,Li Y,Zhang J,Shi B,Zhang F,Hou X,Zhang X,Cui W,Li J,Yao H,Li X,Gao Y,Jiang J

Tue Feb 28 00:00:00 EST 2023

Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.

Journal of neuroinflammation

He D,Fu S,Ye B,Wang H,He Y,Li Z,Li J,Gao X,Liu D

Wed Mar 29 00:00:00 EDT 2023

Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.

Journal of neuroinflammation

He D,Fu S,Ye B,Wang H,He Y,Li Z,Li J,Gao X,Liu D

Wed Mar 29 00:00:00 EDT 2023

Peroxiredoxin 2 Is a Potential Objective Indicator for Severity and the Clinical Status of Subarachnoid Hemorrhage Patients.

Disease markers

Peng Z,Pang C,Li XJ,Zhang HS,Zhang JT,Zhu Q,Xu HJ,Gao YY,Zhuang Z,Li W,Zhang QR,Lu Y,Hang CH

Fri Feb 17 00:00:00 EST 2023

BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion.

International immunopharmacology

Guo K,Shang Y,Wang Z,Li Y,Chen J,Zhu B,Zhang D,Chen J

Thu Jun 01 00:00:00 EDT 2023

BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion.

International immunopharmacology

Guo K,Shang Y,Wang Z,Li Y,Chen J,Zhu B,Zhang D,Chen J

Thu Jun 01 00:00:00 EDT 2023

Sodium butyrate reduces overnutrition-induced microglial activation and hypothalamic inflammation.

International immunopharmacology

Wang X,Duan C,Li Y,Lu H,Guo K,Ge X,Chen T,Shang Y,Liu H,Zhang D

Sat Oct 01 00:00:00 EDT 2022

Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke.

Brain pathology (Zurich, Switzerland)

Hase Y,Ameen-Ali KE,Waller R,Simpson JE,Stafford C,Mahesh A,Ryan L,Pickering L,Bodman C,Hase M,Boche D,Horsburgh K,Wharton SB,Kalaria RN

Tue Nov 01 00:00:00 EDT 2022

Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke.

Brain pathology (Zurich, Switzerland)

Hase Y,Ameen-Ali KE,Waller R,Simpson JE,Stafford C,Mahesh A,Ryan L,Pickering L,Bodman C,Hase M,Boche D,Horsburgh K,Wharton SB,Kalaria RN

Tue Nov 01 00:00:00 EDT 2022

Malignant Melanoma-Derived Exosomes Induce Endothelial Damage and Glial Activation on a Human BBB Chip Model.

Biosensors

Wang P,Wu Y,Chen W,Zhang M,Qin J

Mon Jan 31 00:00:00 EST 2022

Repair of Spinal Cord Injury by Inhibition of PLK4 Expression Through Local Delivery of siRNA-Loaded Nanoparticles.

Journal of molecular neuroscience : MN

Gu Y,Zhang R,Jiang B,Xu X,Guan JJ,Jiang XJ,Zhou Y,Zhou YL,Chen X

Tue Mar 01 00:00:00 EST 2022

Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice.

Phytotherapy research : PTR

Zhu C,Tian M,Liu N,Ma L,Lan X,Yang J,Du J,Ma H,Li Y,Zheng P,Yu J,Peng X

Thu Sep 01 00:00:00 EDT 2022

An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation.

Cell & bioscience

Ferretti G,Romano A,Sirabella R,Serafini S,Maier TJ,Matrone C

Tue Nov 08 00:00:00 EST 2022

Plasminogen Activator Urokinase Receptor Implies Immunosuppressive Features and Acts as an Unfavorable Prognostic Biomarker in Glioma.

The oncologist

Zeng F,Li G,Liu X,Zhang K,Huang H,Jiang T,Zhang Y

Sun Aug 01 00:00:00 EDT 2021

Senkyunolide I Protects against Sepsis-Associated Encephalopathy by Attenuating Sleep Deprivation in a Murine Model of Cecal Ligation and Puncture.

Oxidative medicine and cellular longevity

Xie J,Zhao ZZ,Li P,Zhu CL,Guo Y,Wang J,Deng XM,Wang JF

Thu Sep 09 00:00:00 EDT 2021

Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.

Journal of neuroinflammation

Huo S,Ren J,Ma Y,Ozathaley A,Yuan W,Ni H,Li D,Liu Z

Fri Nov 26 00:00:00 EST 2021

CCP1, a Tubulin Deglutamylase, Increases Survival of Rodent Spinal Cord Neurons following Glutamate-Induced Excitotoxicity.

eNeuro

Ramadan YH,Gu A,Ross N,McEwan SA,Barr MM,Firestein BL,O'Hagan R

Fri Jun 18 00:00:00 EDT 2021

Proto-oncogene tyrosine-protein kinase SRC (Src) inhibition in microglia relieves neuroinflammation in neuropathic pain mouse models.

Bioengineered

Cai Y,Xu J,Cheng Q

Wed Dec 01 00:00:00 EST 2021

Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.

Stem cells and development

Xu C,Diao YF,Wang J,Liang J,Xu HH,Zhao ML,Zheng B,Luan Z,Wang JJ,Yang XP,Wei MG,Duan JH,Wang KQ,Chen C,Chen F,Ming D,Zhang S,Sun HT,Li XH

Sat Feb 15 00:00:00 EST 2020

Bioinformatics

Protein Aliases: AIF-1; Allograft inflammatory factor 1; DADB-70P7.8; DASS-82G15.2; Em:AF129756.17; Iba; interferon gamma responsive transcript; Ionized calcium-binding adapter molecule 1; Protein G1

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Gene Aliases: AIF-1; AIF1; G1; IBA1; IRT-1; IRT1

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UniProt ID: (Human) P55008

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Entrez Gene ID: (Human) 199

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Function(s)

molecular_function calcium ion binding actin filament binding calmodulin-related

Process(es)

microglial cell activation positive regulation of protein phosphorylation phagocytosis, engulfment inflammatory response negative regulation of gene expression positive regulation of muscle hyperplasia Rac protein signal transduction actin filament polymerization cellular response to extracellular stimulus cellular response to hormone stimulus positive regulation of T cell proliferation negative regulation of apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation response to axon injury actin filament bundle assembly response to glucocorticoid response to electrical stimulus cellular response to morphine cellular response to interferon-gamma cellular response to hydroperoxide negative regulation of smooth muscle cell chemotaxis positive regulation of smooth muscle cell chemotaxis positive regulation of monocyte chemotaxis ruffle assembly positive regulation of G1/S transition of mitotic cell cycle positive regulation of T cell migration

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IBA1 Monoclonal Antibody (1C6A10)

IBA1 Antibody (66827-1-IG) in IHC (P)

Product Details

66827-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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