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FIGURE: 1 / 1
Sequence of this protein is as follows: MSGHKCYPWD LQDRYAQDKS VVNKMQQKYW ETKQAFIKAT GKKEDEHVVA SDADLDAKLE LFHSIQRTCL DLSKAIVLYQ KRICFLSQEE NELGKFLRSQ GFQDKTRAGK MMQATGKALC FSSQQRLALR NPLCRFHQEV ETFRHRAISD TWLTVNRMEQ CRTEYRGALL WMKDVSQELD PDLYKQMEKF RKVQTQVRLA KKNFDKLKMD VCQKVDLLGA SRCNLLSHML ATYQTTLLHF WEKTSHTMAA IHESFKGYQP YEFTTLKSLQ DPMKKLVEKE EKKKINQQES TDAAVQEPSQ LISLEEENQR KESSSFKTED GKSILSALDK GSTHTACSGP IDELLDMKSE EGACLGPVAG TPEPEGADKD DLLLLSEIFN ASSLEEGEFS KEWAAVFGDG QVKEPVPTMA LGEPDPKAQT GSGFLPSQLL DQNMKDLQAS LQEPAKAASD LTAWFSLFAD LDPLSNPDAV GKTDKEHELL NA
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
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Protein Aliases: 69 kDa islet cell autoantigen; diabetes mellitus type I autoantigen; ICA69; ICAp69; Islet cell autoantigen 1; islet cell autoantigen 1 isoform; islet cell autoantigen 1, 69kDa; Islet cell autoantigen p69; p69; testicular tissue protein Li 162
Gene Aliases: ICA1; ICA69; ICAp69
UniProt ID: (Human) Q05084
Entrez Gene ID: (Human) 3382
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