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This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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Protein Aliases: CD242; CD242 antigen; ICAM-4; Intercellular adhesion molecule 4; intercellular adhesion molecule 4 (LW blood group); intercellular adhesion molecule 4 isoform 3 anitgen LWa; Landsteiner-Wiener blood group antigen a; Landsteiner-Wiener blood group glycoprotein; LW blood group protein; LW glycoprotein
Gene Aliases: 1810015M19Rik; CD242; ICAM-4; ICAM4; LW
UniProt ID: (Human) Q14773, (Mouse) Q9ERM2
Entrez Gene ID: (Human) 3386, (Mouse) 78369, (Rat) 298702
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