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ICOS (CD278) encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family. It functions as a homodimer and has a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation. ICOS has been linked to various disorders, including Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.
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Protein Aliases: Activation-inducible lymphocyte immunomediatory molecule; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; inducible costimulator; inducible T-cell co-stimulator; Inducible T-cell costimulator
Gene Aliases: AILIM; CCLP; CD278; CRP-1; CVID1; H4; ICOS; Ly115
UniProt ID: (Human) Q9Y6W8, (Rat) Q9R1T7, (Mouse) Q9WVS0
Entrez Gene ID: (Human) 29851, (Rat) 64545, (Mouse) 54167
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