Proteintech

IDO1 Polyclonal Antibody

IDO1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

IDO1 Antibody (13268-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 13268-1-AP ( IDO1 Antibody) at dilution of 1:100 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

13268-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 41 publications 41 publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IDO1 Fusion Protein Ag3953 (1-403 aa encoded by BC027882)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAHAMENSW TISKEYHIDE EVGFALPNPQ ENLPDFYNDW MFIAKHLPDL IESGQLRERV EKLNMLSIDH LTDHKSQRLA RLVLGCITMA YVWGKGHGDV RKVLPRNIAV PYCQLSKKLE LPPILVYADC VLANWKKKDP NKPLTYENMD VLFSFRDGDC SKGFFLVSLL VEIAAASAIK VIPTVFKAMQ MQERDTLLKA LLEIASCLEK ALQVFHQIHD HVNPKAFFSV LRIYLSGWKG NPQLSDGLVY EGFWEDPKEF AGGSAGQSSV FQCFDVLLGI QQTAGGGHAA QFLQDMRRYM PPAHRNFLCS LESNPSVREF VLSKGDAGLR EAYDACVKAL VSLRSYHLQI VTKYILIPAS QQPKENKTSE DPSKLEAKGT GGTDLMNFLK TVRSTTEKSL LKEG (1-403 aa encoded by BC027882)

Target Information

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

IDO1 Promotes the Progression of NSCLC by Regulating the Polarization of M2 Macrophages.

International journal of general medicine

Chen X,Yao J,Zhang MY,Li R,Liu X,Qu YQ

Wed May 17 00:00:00 EDT 2023

Targeting the STAT5A/IDO1 axis overcomes radioresistance and reverses the immunosuppressive tumor microenvironment in NSCLC.

International journal of oncology

Yang Y,Zheng X,Ni P,Li D,Dan Q,Wang X,Wang Y,Sun Y,Liu K,Dong Z,Ge H

Sun Jan 01 00:00:00 EST 2023

Targeting the STAT5A/IDO1 axis overcomes radioresistance and reverses the immunosuppressive tumor microenvironment in NSCLC.

International journal of oncology

Yang Y,Zheng X,Ni P,Li D,Dan Q,Wang X,Wang Y,Sun Y,Liu K,Dong Z,Ge H

Sun Jan 01 00:00:00 EST 2023

Kuqin ameliorates Lipopolysaccharide-induced acute lung injury by regulating indoleamine 2,3-dioxygenase 1 and Akkermansia muciniphila.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Xiong S,Sun H,Lu C,He J,Wu Z,Wang Y,Zheng Q

Wed Feb 01 00:00:00 EST 2023

Serum Response Factor-Regulated IDO1/Kyn-Ahr Pathway Promotes Tumorigenesis of Oral Squamous Cell Carcinoma.

Cancers

Xu M,Zhu F,Yin Q,Yin H,Fang S,Luo G,Huang J,Huang W,Liu F,Zhong M,Deng X

Sun Feb 19 00:00:00 EST 2023

DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota.

The Journal of nutritional biochemistry

Zhao LP,Wu J,Quan W,Zhou Y,Hong H,Niu GY,Huang SB,Qiao CM,Zhao WJ,Cui C,Shen YQ

Mon May 01 00:00:00 EDT 2023

Novel long non-coding RNAs associated with inflammation and macrophage activation in human.

Scientific reports

Chini A,Guha P,Malladi VS,Guo Z,Mandal SS

Fri Mar 10 00:00:00 EST 2023

Apigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling.

NeuroImmune pharmacology and therapeutics

Sales D,Lin E,Stoffel V,Dickson S,Khan ZK,Beld J,Jain P

Sat Mar 25 00:00:00 EDT 2023

Impact of the combination of sintilimab and chemotherapy on the tumor and paratumor PD-L1, IDO, TIM-3, FOXP3+ and CD8 expressions in patients with advanced esophageal squamous cell carcinoma.

Thoracic cancer

Zhang S,Cai H,Huang J,Wang G

Thu Dec 01 00:00:00 EST 2022

Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice.

Behavioural brain research

Wang Q,Sun YN,Zou CM,Zhang TL,Li Z,Liu M,Shi BY,Shi SS,Yu CY,Wei TM

Sat Mar 26 00:00:00 EDT 2022

DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.

Frontiers in immunology

Zhao LP,Wu J,Quan W,Zhou Y,Hong H,Niu GY,Li T,Huang SB,Qiao CM,Zhao WJ,Cui C,Shen YQ

Tue Feb 14 00:00:00 EST 2023

Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.

Journal of medicinal chemistry

Zhang Y,Li Y,Chen X,Chen X,Chen C,Wang L,Dong X,Wang G,Gu R,Li F,Han F,Chen D

Thu Aug 25 00:00:00 EDT 2022

Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.

Journal of medicinal chemistry

Zhang Y,Li Y,Chen X,Chen X,Chen C,Wang L,Dong X,Wang G,Gu R,Li F,Han F,Chen D

Thu Aug 25 00:00:00 EDT 2022

RSAD2 Is an Effective Target for High-Yield Vaccine Production in MDCK Cells.

Viruses

Qiao Z,Liao Y,Pei M,Qiu Z,Liu Z,Jin D,Zhang J,Ma Z,Yang X

Mon Nov 21 00:00:00 EST 2022

Blockage of the IDO1 pathway by charge-switchable nanoparticles amplifies immunogenic cell death for enhanced cancer immunotherapy.

Acta biomaterialia

Shi M,Zhang J,Wang Y,Han Y,Zhao X,Hu H,Qiao M,Chen D

Thu Sep 15 00:00:00 EDT 2022

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Journal of immunology (Baltimore, Md. : 1950)

Fan TW,Daneshmandi S,Cassel TA,Uddin MB,Sledziona J,Thompson PT,Lin P,Higashi RM,Lane AN

Tue Nov 01 00:00:00 EDT 2022

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.

Nature communications

Kim YS,Ko B,Kim DJ,Tak J,Han CY,Cho JY,Kim W,Kim SG

Fri Oct 14 00:00:00 EDT 2022

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.

Nature communications

Kim YS,Ko B,Kim DJ,Tak J,Han CY,Cho JY,Kim W,Kim SG

Fri Oct 14 00:00:00 EDT 2022

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.

Nature communications

Kim YS,Ko B,Kim DJ,Tak J,Han CY,Cho JY,Kim W,Kim SG

Fri Oct 14 00:00:00 EDT 2022

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.

Nature communications

Kim YS,Ko B,Kim DJ,Tak J,Han CY,Cho JY,Kim W,Kim SG

Fri Oct 14 00:00:00 EDT 2022

Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway.

ACS applied materials & interfaces

Yang J,Li H,Hao Z,Jing X,Zhao Y,Cheng X,Ma H,Wang J,Wang J

Wed Jan 26 00:00:00 EST 2022

Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway.

EMBO reports

Sriwastva MK,Deng ZB,Wang B,Teng Y,Kumar A,Sundaram K,Mu J,Lei C,Dryden GW,Xu F,Zhang L,Yan J,Zhang X,Park JW,Merchant ML,Egilmez NK,Zhang HG

Thu Feb 03 00:00:00 EST 2022

Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD⁺ salvage metabolic pathway.

Gut pathogens

Cao P,Chen Q,Shi C,Wang L,Gong Z

Tue Jun 28 00:00:00 EDT 2022

Fusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD⁺ salvage metabolic pathway.

Gut pathogens

Cao P,Chen Q,Shi C,Wang L,Gong Z

Tue Jun 28 00:00:00 EDT 2022

Cassane diterpenoid ameliorates dextran sulfate sodium-induced experimental colitis by regulating gut microbiota and suppressing tryptophan metabolism.

Frontiers in immunology

Liu T,Ning Z,Liu P,Gao H

Tue Feb 07 00:00:00 EST 2023

The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.

Nutrients

Mudhish EA,Siddique AB,Ebrahim HY,Abdelwahed KS,King JA,El Sayed KA

Mon Apr 04 00:00:00 EDT 2022

Inhibitory and Stimulatory Effects of IL-32 on HIV-1 Infection.

Journal of immunology (Baltimore, Md. : 1950)

Nasser H,Takahashi N,Eltalkhawy YM,Reda O,Lotfi S,Nasu K,Sakuragi JI,Suzu S

Thu Sep 01 00:00:00 EDT 2022

Therapeutic efficacy of human adipose mesenchymal stem cells in Crohn's colon fibrosis is improved by IFN-γ and kynurenic acid priming through indoleamine 2,3-dioxygenase-1 signaling.

Stem cell research & therapy

Ye Y,Zhang X,Su D,Ren Y,Cheng F,Yao Y,Shi G,Ji Y,Chen S,Shi P,Dai L,Su X,Deng H

Thu Sep 08 00:00:00 EDT 2022

Predicting Panel of Metabolism and Immune-Related Genes for the Prognosis of Human Ovarian Cancer.

Frontiers in cell and developmental biology

Zhang L,Sun W,Ren W,Zhang J,Xu G

Mon Apr 25 00:00:00 EDT 2022

IDO1 as a new immune biomarker for diabetic nephropathy and its correlation with immune cell infiltration.

International immunopharmacology

Yu K,Li D,Xu F,Guo H,Feng F,Ding Y,Wan X,Sun N,Zhang Y,Fan J,Liu L,Yang H,Yang X

Sat May 01 00:00:00 EDT 2021

Elevated mRNA Level of Y-Box Binding Protein 1 Indicates Unfavorable Prognosis Correlated with Macrophage Infiltration and T Cell Exhaustion in Luminal Breast Cancer.

Cancer management and research

Lv Z,Xue C,Zhang L,Sun J,Bo C

Tue Apr 26 00:00:00 EDT 2022

Elevated mRNA Level of Y-Box Binding Protein 1 Indicates Unfavorable Prognosis Correlated with Macrophage Infiltration and T Cell Exhaustion in Luminal Breast Cancer.

Cancer management and research

Lv Z,Xue C,Zhang L,Sun J,Bo C

Tue Apr 26 00:00:00 EDT 2022

Tryptophan potentiates CD8⁺ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.

Journal for immunotherapy of cancer

Qin R,Zhao C,Wang CJ,Xu W,Zhao JY,Lin Y,Yuan YY,Lin PC,Li Y,Zhao S,Huang Y

Thu Jul 01 00:00:00 EDT 2021

GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer.

Journal for immunotherapy of cancer

Wei JL,Wu SY,Yang YS,Xiao Y,Jin X,Xu XE,Hu X,Li DQ,Jiang YZ,Shao ZM

Thu Jul 01 00:00:00 EDT 2021

Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy.

Frontiers in cellular neuroscience

Deng N,Hu J,Hong Y,Ding Y,Xiong Y,Wu Z,Xie W

Wed Mar 10 00:00:00 EST 2021

Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Fan L,Peng Y,Wang J,Ma P,Zhao L,Li X

Mon Mar 01 00:00:00 EST 2021

Cang-Ai Volatile Oil Ameliorates Depressive Behavior Induced by Chronic Stress Through IDO-Mediated Tryptophan Degradation Pathway.

Frontiers in psychiatry

Zhang K,Lei N,Li M,Li J,Li C,Shen Y,Guo P,Xiong L,Xie Y

Tue Jan 04 00:00:00 EST 2022

Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.

Cancer immunology, immunotherapy : CII

Yang P,Wang K,Zhang C,Wang Z,Liu Q,Wang J,Jiang T,Shan X

Wed Sep 01 00:00:00 EDT 2021

Mifepristone regulates Tregs function mediated by dendritic cells through suppressing the expression of TGF-β.

Immunopharmacology and immunotoxicology

Li Y,Cao L,Qian Z,Guo Q,Niu X,Huang L

Mon Feb 01 00:00:00 EST 2021

Combined Metabolomic Analysis of Plasma and Tissue Reveals a Prognostic Risk Score System and Metabolic Dysregulation in Esophageal Squamous Cell Carcinoma.

Frontiers in oncology

Chen Z,Dai Y,Huang X,Chen K,Gao Y,Li N,Wang D,Chen A,Yang Q,Hong Y,Zeng S,Mao W

Thu Oct 01 00:00:00 EDT 2020

Nrf2 modulates immunosuppressive ability and cellular senescence of human umbilical cord mesenchymal stem cells.

Biochemical and biophysical research communications

Jie Z,Huan Y,Mengyun W,Yasha L,Huafeng P,Ke Y

Thu Jun 11 00:00:00 EDT 2020

Plasmacytoid Dendritic Cells Protect Against Middle Cerebral Artery Occlusion Induced Brain Injury by Priming Regulatory T Cells.

Frontiers in cellular neuroscience

Chen C,Chencheng Z,Cuiying L,Xiaokun G

Mon Sep 28 00:00:00 EDT 2020

1,25(OH)₂D₃ mitigate cancer-related fatigue in tumor-bearing mice: Integrating network pharmacological analysis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhou YT,Li SS,Ai M,Chen H,Liu YX,Li BY,Zhao Y,Cai WW,Hou B,Ni LL,Xu F,Qiu LY

Sat Aug 01 00:00:00 EDT 2020

Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Qiu H,Zhang J,Guo Q,Zhang Y,Zhong X

Sat Aug 01 00:00:00 EDT 2020

Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.

Toxicology and applied pharmacology

Ebokaiwe AP,Njoya EM,Sheng Y,Zhang Z,Li S,Zhou Z,Qiang Z,Peng T,Hussein AA,Zhang G,Lu X,Li L,Wang F

Thu Oct 01 00:00:00 EDT 2020

IDO1 Expression Increased After Neoadjuvant Therapy Predicts Poor Pathologic Response and Prognosis in Esophageal Squamous Cell Carcinoma.

Frontiers in oncology

Jiao R,Zheng X,Sun Y,Feng Z,Song S,Ge H

Mon Sep 28 00:00:00 EDT 2020

Multiple myeloma cell-derived IL-32γ increases the immunosuppressive function of macrophages by promoting indoleamine 2,3-dioxygenase (IDO) expression.

Cancer letters

Yan H,Dong M,Liu X,Shen Q,He D,Huang X,Zhang E,Lin X,Chen Q,Guo X,Chen J,Zheng G,Wang G,He J,Yi Q,Cai Z

Mon Apr 01 00:00:00 EDT 2019

Multiple myeloma cell-derived IL-32γ increases the immunosuppressive function of macrophages by promoting indoleamine 2,3-dioxygenase (IDO) expression.

Cancer letters

Yan H,Dong M,Liu X,Shen Q,He D,Huang X,Zhang E,Lin X,Chen Q,Guo X,Chen J,Zheng G,Wang G,He J,Yi Q,Cai Z

Mon Apr 01 00:00:00 EDT 2019

Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.

International immunopharmacology

Zhang WY,Guo YJ,Han WX,Yang MQ,Wen LP,Wang KY,Jiang P

Fri Feb 01 00:00:00 EST 2019

Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.

International immunopharmacology

Zhang WY,Guo YJ,Han WX,Yang MQ,Wen LP,Wang KY,Jiang P

Fri Feb 01 00:00:00 EST 2019

Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons.

Frontiers in cellular and infection microbiology

Bando H,Lee Y,Sakaguchi N,Pradipta A,Sakamoto R,Tanaka S,Ma JS,Sasai M,Yamamoto M

Mon Jan 27 00:00:00 EST 2020

Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor.

Theranostics

Huang Z,Wei G,Zeng Z,Huang Y,Huang L,Shen Y,Sun X,Xu C,Zhao C

Tue Aug 18 00:00:00 EDT 2020

Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide.

European journal of nutrition

Dang R,Zhou X,Tang M,Xu P,Gong X,Liu Y,Jiao H,Jiang P

Sun Apr 01 00:00:00 EDT 2018

Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide.

European journal of nutrition

Dang R,Zhou X,Tang M,Xu P,Gong X,Liu Y,Jiao H,Jiang P

Sun Apr 01 00:00:00 EDT 2018

Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.

mBio

Bando H,Lee Y,Sakaguchi N,Pradipta A,Ma JS,Tanaka S,Cai Y,Liu J,Shen J,Nishikawa Y,Sasai M,Yamamoto M

Tue Oct 09 00:00:00 EDT 2018

Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.

mBio

Bando H,Lee Y,Sakaguchi N,Pradipta A,Ma JS,Tanaka S,Cai Y,Liu J,Shen J,Nishikawa Y,Sasai M,Yamamoto M

Tue Oct 09 00:00:00 EDT 2018

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.

Frontiers in immunology

Bando H,Sakaguchi N,Lee Y,Pradipta A,Ma JS,Tanaka S,Lai DH,Liu J,Lun ZR,Nishikawa Y,Sasai M,Yamamoto M

Mon Sep 30 00:00:00 EDT 2019

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.

Frontiers in immunology

Bando H,Sakaguchi N,Lee Y,Pradipta A,Ma JS,Tanaka S,Lai DH,Liu J,Lun ZR,Nishikawa Y,Sasai M,Yamamoto M

Mon Sep 30 00:00:00 EDT 2019

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.

Frontiers in immunology

Bando H,Sakaguchi N,Lee Y,Pradipta A,Ma JS,Tanaka S,Lai DH,Liu J,Lun ZR,Nishikawa Y,Sasai M,Yamamoto M

Mon Sep 30 00:00:00 EDT 2019

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.

Frontiers in immunology

Bando H,Sakaguchi N,Lee Y,Pradipta A,Ma JS,Tanaka S,Lai DH,Liu J,Lun ZR,Nishikawa Y,Sasai M,Yamamoto M

Mon Sep 30 00:00:00 EDT 2019

Impact of mismatch-repair deficiency on the colorectal cancer immune microenvironment.

Oncotarget

Zhang Y,Sun Z,Mao X,Wu H,Luo F,Wu X,Zhou L,Qin J,Zhao L,Bai C

Tue Oct 17 00:00:00 EDT 2017

Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.

Hepatology (Baltimore, Md.)

Yoshio S,Sugiyama M,Shoji H,Mano Y,Mita E,Okamoto T,Matsuura Y,Okuno A,Takikawa O,Mizokami M,Kanto T

Fri Jan 01 00:00:00 EST 2016

Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B.

Hepatology (Baltimore, Md.)

Yoshio S,Sugiyama M,Shoji H,Mano Y,Mita E,Okamoto T,Matsuura Y,Okuno A,Takikawa O,Mizokami M,Kanto T

Fri Jan 01 00:00:00 EST 2016

Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery.

International journal of pharmaceutics

Li Y,Hei M,Xu Y,Qian X,Zhu W

Sun Sep 25 00:00:00 EDT 2016

Ammonium salt modified mesoporous silica nanoparticles for dual intracellular-responsive gene delivery.

International journal of pharmaceutics

Li Y,Hei M,Xu Y,Qian X,Zhu W

Sun Sep 25 00:00:00 EDT 2016

Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Zhang Z,Han Y,Song J,Luo R,Jin X,Mu D,Su S,Ji X,Ren YF,Liu H

Thu Jan 01 00:00:00 EST 2015

Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Zhang Z,Han Y,Song J,Luo R,Jin X,Mu D,Su S,Ji X,Ren YF,Liu H

Thu Jan 01 00:00:00 EST 2015

Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Zhang Z,Han Y,Song J,Luo R,Jin X,Mu D,Su S,Ji X,Ren YF,Liu H

Thu Jan 01 00:00:00 EST 2015

Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Zhang Z,Han Y,Song J,Luo R,Jin X,Mu D,Su S,Ji X,Ren YF,Liu H

Thu Jan 01 00:00:00 EST 2015

Bioinformatics

Protein Aliases: EC 1.13.11.52; IDO-1; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine; Indoleamine 2,3-dioxygenase 1; Indoleamine-2; Indoleamine-pyrrole 2,3-dioxygenase

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Gene Aliases: IDO; IDO-1; IDO1; INDO

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UniProt ID: (Human) P14902

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Entrez Gene ID: (Human) 3620

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Function(s)

tryptophan 2,3-dioxygenase activity electron carrier activity heme binding indoleamine 2,3-dioxygenase activity metal ion binding oxygenase

Process(es)

immune system process cytokine production involved in inflammatory response positive regulation of T cell tolerance induction positive regulation of chronic inflammatory response positive regulation of type 2 immune response tryptophan catabolic process female pregnancy tryptophan catabolic process to kynurenine response to lipopolysaccharide negative regulation of interleukin-10 production positive regulation of interleukin-12 production multicellular organismal response to stress kynurenic acid biosynthetic process swimming behavior negative regulation of T cell proliferation regulation of activated T cell proliferation oxidation-reduction process negative regulation of T cell apoptotic process positive regulation of T cell apoptotic process

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IDO1 Polyclonal Antibody

IDO1 Antibody (13268-1-AP) in IHC (P)

Product Details

13268-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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