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Product Details
66528-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3G2G11
Immunogen
IDO1 Fusion Protein Ag3953 (1-403 aa encoded by BC027882)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAHAMENSW TISKEYHIDE EVGFALPNPQ ENLPDFYNDW MFIAKHLPDL IESGQLRERV EKLNMLSIDH LTDHKSQRLA RLVLGCITMA YVWGKGHGDV RKVLPRNIAV PYCQLSKKLE LPPILVYADC VLANWKKKDP NKPLTYENMD VLFSFRDGDC SKGFFLVSLL VEIAAASAIK VIPTVFKAMQ MQERDTLLKA LLEIASCLEK ALQVFHQIHD HVNPKAFFSV LRIYLSGWKG NPQLSDGLVY EGFWEDPKEF AGGSAGQSSV FQCFDVLLGI QQTAGGGHAA QFLQDMRRYM PPAHRNFLCS LESNPSVREF VLSKGDAGLR EAYDACVKAL VSLRSYHLQI VTKYILIPAS QQPKENKTSE DPSKLEAKGT GGTDLMNFLK TVRSTTEKSL LKEG (1-403 aa encoded by BC027882)
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 1.13.11.52; IDO-1; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine; Indoleamine 2,3-dioxygenase 1; indoleamine 23-dioxygenase; Indoleamine-2; indoleamine-pyrrole 2,3 dioxygenase; Indoleamine-pyrrole 2,3-dioxygenase
Gene Aliases: IDO; IDO-1; IDO1; INDO
UniProt ID: (Human) P14902, (Mouse) P28776, (Rat) Q9ERD9
Entrez Gene ID: (Human) 3620, (Mouse) 15930, (Rat) 66029
immune system process
cytokine production involved in inflammatory response
positive regulation of T cell tolerance induction
positive regulation of chronic inflammatory response
positive regulation of type 2 immune response
tryptophan catabolic process
female pregnancy
tryptophan catabolic process to kynurenine
response to lipopolysaccharide
negative regulation of interleukin-10 production
positive regulation of interleukin-12 production
multicellular organismal response to stress
kynurenic acid biosynthetic process
swimming behavior
negative regulation of T cell proliferation
regulation of activated T cell proliferation
oxidation-reduction process
negative regulation of T cell apoptotic process
positive regulation of T cell apoptotic process
defense response
inflammatory response
positive regulation of apoptotic process
negative regulation of activated T cell proliferation
Performance Guarantee
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