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IFN alpha Antibody (PA5-119649) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of IFNA1 in SH-SY5Y cells (green) using IFN alpha Polyclonal Antibody (Product # PA5-119649). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Product Details
PA5-119649
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within mouse IFNA1 aa 140-181
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913222
Product Specific Information
Positive Control: Mouse liver tissue lysate, N2A, SHG-44, SH-SY5Y, rat brain tissue, human kidney tissue, mouse brain tissue.
Subcellular Location: Secreted.
Target Information
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-2a interferon; ifa; IFN alpha 1/13; IFN alpha 1b; IFN α; IFN-alpha 1b; IFN-alpha-1; IFN-alpha-1/13; IFN-alpha-2; IFNAalphaIFN-alpha-1/13; IFNalpha; IFNα; Interferon alpha 13 (IFNA13); interferon alpha 15; interferon alpha 1b; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha family gene 1; interferon alpha family, gene 2; Interferon alpha leukocyte (IFL); Interferon alpha-1; Interferon alpha-1/13; Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-2; Interferon alpha-A; Interferon alpha-D; Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); interferon, alpha 1; interferon, alpha 2; interferon-alpha1; LeIF A; LeIF D; MGC138207; MGC138505; MGC138507; novel interferon alpha (Ifna) family member
Gene Aliases: Gm12597; Ifa1; Ifa2; IFL; IFN; IFN-ALPHA; IFN-alpha1; IFN-alphaA; IFN-alphaD; IFNA; IFNA1; IFNA13; IFNA2; IFNA2A; IFNA2B; IFNA2C; IFNA@; Ifnaa; INFA2; MuIFN-alpha-A; OTTMUSG00000007655
UniProt ID: (Human) P01562, (Human) P01563, (Mouse) P01572, (Rat) P05011
Entrez Gene ID: (Human) 3439, (Human) 3440, (Mouse) 15962, (Rat) 298210, (Mouse) 242517, (Rat) 298213, (Mouse) 15965
adaptive immune response
T cell activation involved in immune response
natural killer cell activation involved in immune response
humoral immune response
blood coagulation
cytokine-mediated signaling pathway
B cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
B cell proliferation
response to exogenous dsRNA
innate immune response
defense response to virus
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
apoptotic process
inflammatory response
cell surface receptor signaling pathway
cell-cell signaling
negative regulation of gene expression
positive regulation of phosphorylation
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of viral entry into host cell
negative regulation of T-helper 2 cell cytokine production
negative regulation of interleukin-5 secretion
negative regulation of interleukin-13 secretion
defense response
defense response to bacterium
regulation of MHC class I biosynthetic process
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