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Product Details
MA1-35482
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2-48
Immunogen
E.coli derived recombinant human interferon alpha 1
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
purified
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2248769
Product Specific Information
The alpha interferons are involved in virus resistance in target cells for these viruses. They are known to block cell proliferation and to regulate MHC class I antigen expression. The IFNα family has over 20 genes and pseudogenes in two families (I and II), one with a mature length of 166aa and one of 172aa. Cells producing IFNα are lymphocytes, monocytes, macrophages and cell lines such as Namalwa and KGI. Bioassays for IFNα include cytopathic effect blocking, by viruses such as VSV, SFV and BMCV, on their target cells. A number of receptors for IFNα are now known and seem to be expressed on most cell types. 2-48 Is specific for human interferon α 1 and does not cross react with human interferon α 2.
Target Information
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-2a interferon; ifa; IFN alpha 1/13; IFN alpha 1b; IFN α; IFN-alpha 1b; IFN-alpha-1/13; IFN-alpha-2; IFNAalphaIFN-alpha-1/13; IFNalpha; IFNα; Interferon alpha 13 (IFNA13); interferon alpha 1b; interferon alpha 2a; interferon alpha 2b; interferon alpha A; Interferon alpha leukocyte (IFL); Interferon alpha-1/13; Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-2; Interferon alpha-A; Interferon alpha-D; Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); interferon, alpha 1; interferon, alpha 2; interferon-alpha1; LeIF A; LeIF D; MGC138207; MGC138505; MGC138507
Gene Aliases: IFL; IFN; IFN-ALPHA; IFN-alphaA; IFN-alphaD; IFNA; IFNA1; IFNA13; IFNA2; IFNA2A; IFNA2B; IFNA2C; IFNA@; INFA2
UniProt ID: (Human) P01562, (Human) P01563
Entrez Gene ID: (Human) 3439, (Human) 3440
adaptive immune response
T cell activation involved in immune response
natural killer cell activation involved in immune response
humoral immune response
blood coagulation
cytokine-mediated signaling pathway
B cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
B cell proliferation
response to exogenous dsRNA
innate immune response
defense response to virus
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
apoptotic process
inflammatory response
cell surface receptor signaling pathway
cell-cell signaling
negative regulation of gene expression
positive regulation of phosphorylation
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of viral entry into host cell
negative regulation of T-helper 2 cell cytokine production
negative regulation of interleukin-5 secretion
negative regulation of interleukin-13 secretion
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