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Invitrogen
IFN beta Polyclonal Antibody
FIGURE: 1 / 1
IFN beta Antibody (324001) in ELISA
BMC microbiology 2015 -
Fig. 3 Cytokine induction in BMDM infected with C. pneumoniae strains AO3 or AR39. BMDMs were prepared as described in the Methods. The cells were infected with AO3 or AR39 at the indicated MOI, and incubated at 35 degC or 37 degC. Supernatant was harvested at 24 h post infection and assayed for ( a ) IL-1beta, ( b ) IL-6 and ( c ) IFN-beta. Graphs depict the mean +- SEM, and are representative of 3 indepen... View More
Product Details
324001
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant mouse interferon beta
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum, PBS
Contains
no preservative
Storage conditions
-80° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
RRID
AB_223494
Product Specific Information
Specificity: Neutralizes mouse interferon beta.
Activity: 1.55x10^6 NU/mL. Interferon was titrated with the use of the cytopathic effect inhibition assay using L929 cells with EMCV, where 2.5 unit/mL of interferon was necessary to produce an endpoint of 50%. One neutralization unit is defined as the amount of serum required to neutralize one unit of mouse IFN beta to an endpoint of 50%.
For retention of full activity, do not store above -70ºC.
Packaged by and distributed for PBL Assay Science.
Target Information
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon b; Interferon beta; RP11-113D19.1
Gene Aliases: Ifb; IFN-beta; IFNB; Ifnb1
UniProt ID: (Mouse) P01575
Entrez Gene ID: (Mouse) 15977
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
defense response
humoral immune response
cytokine-mediated signaling pathway
B cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
cellular response to interferon-beta
B cell proliferation
defense response to bacterium
response to exogenous dsRNA
negative regulation of viral genome replication
negative regulation of T cell differentiation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
type I interferon signaling pathway
cellular response to dexamethasone stimulus
negative regulation of T-helper 2 cell cytokine production
positive regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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