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Proteintech
IFN beta Monoclonal Antibody (2C6E5), NeutraKine®
FIGURE: 1 / 1
IFN beta Antibody (69013-1-IG) in Neu
Recombinant IFN beta (Cat.NO. HZ-1298) inhibits TF-1 cell proliferation at dose dependent manner (blue curve, refer to bottom X-left Y). The activity of human IFN beta (10 ng/mL HZ-1298) is neutralized by mouse anti-human IFN beta monoclonal antibody 69013-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 5-20 ng/mL.
Product Details
69013-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2C6E5
Immunogen
NeutraKine IFN beta fusion protein HZ-1298
Conjugate
Form
Lyophilized
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Reconstitute with water to the desired concentration.
Lyophilized antibodies are stable for 1 year from the date of purchase if stored between -20 to -80°C. Upon reconstitution, we recommend that the solution be stored at 4°C (short- term) or at -20 to -80°Cfor long term. Repeated freeze-thaw cycles should be avoided with reconstituted products.
Aliquoting is unnecessary for -20°C storage.
Target Information
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Fibroblast interferon; IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon b; Interferon beta; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1
Gene Aliases: IFB; IFF; IFN-beta; IFNB; IFNB1
UniProt ID: (Human) P01574
Entrez Gene ID: (Human) 3456
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
humoral immune response
cell surface receptor signaling pathway
blood coagulation
response to virus
natural killer cell activation
B cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
cellular response to interferon-beta
B cell proliferation
defense response to bacterium
response to exogenous dsRNA
negative regulation of viral genome replication
positive regulation of innate immune response
regulation of MHC class I biosynthetic process
negative regulation of T cell differentiation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
cellular response to exogenous dsRNA
cellular response to dexamethasone stimulus
cellular response to virus
negative regulation of T-helper 2 cell cytokine production
positive regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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