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Product Details
MBOIFNG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Goat,
Human,
Mustelid,
Sheep,
Pig
Published species
Human,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CC302
Immunogen
Recombinant Bovine IFN gamma
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
proprietary preservative
Storage conditions
-80°C
Shipping conditions
Dry ice
RRID
AB_417054
Product Specific Information
MBOIFNG targets IFN gamma in ELISA, and FACS applications and shows reactivity with Bovine, Canine, Equine, Goat, Human, Mustelid, Ovine, and Porcine samples.
The MBOIFNG immunogen is recombinant Bovine IFN gamma.
MBOIFNG detects IFN gamma which has a predicted molecular weight of approximately 17 kDa.
Target Information
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BoIFNG; cytokine; gamma-interferon; H-IFN-g; IFN γ; IFN-gamma; IFN-gamma precursor; IFN-y; IFNγ; Immune interferon; Interferon gamma; interferon gamma type 2; Interferon y; Interferon γ; interferon, gamma; interferon-gamma precursor; Interferonγ; M-IFN-g; R-IFN-g
Gene Aliases: IFG; IFI; IFN-G; IFN-gamma; IFNG
UniProt ID: (Horse) P42160, (Sheep) P17773, (Bovine) P07353, (Dog) P42161, (Human) P01579, (Goat) P79154, (Pig) P17803
Entrez Gene ID: (Horse) 100034181, (Sheep) 443396, (Bovine) 281237, (Dog) 403801, (Human) 3458, (Goat) 100860815, (Pig) 396991
microglial cell activation
macrophage activation involved in immune response
cell cycle arrest
positive regulation of autophagy
positive regulation of epithelial cell migration
regulation of protein ADP-ribosylation
macrophage differentiation
positive regulation of B cell proliferation
positive regulation of protein complex assembly
negative regulation of interleukin-17 production
positive regulation of interleukin-12 production
positive regulation of interleukin-23 production
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
positive regulation of peptidyl-serine phosphorylation of STAT protein
positive regulation of smooth muscle cell apoptotic process
regulation of growth
positive regulation of protein import into nucleus
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of chemokine biosynthetic process
positive regulation of nitric oxide biosynthetic process
positive regulation of osteoclast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
astrocyte activation
negative regulation of smooth muscle cell proliferation
positive regulation of cytokine secretion
positive regulation of inflammatory response
positive regulation of neurogenesis
regulation of insulin secretion
positive regulation of membrane protein ectodomain proteolysis
defense response to virus
positive regulation of killing of cells of other organism
interferon-gamma-mediated signaling pathway
positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
positive regulation of fructose 1,6-bisphosphate metabolic process
positive regulation of calcidiol 1-monooxygenase activity
positive regulation of protein serine/threonine kinase activity
positive regulation of protein deacetylation
extrinsic apoptotic signaling pathway
positive regulation of neuron death
positive regulation of beta-amyloid formation
negative regulation of tau-protein kinase activity
positive regulation of core promoter binding
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
neutrophil apoptotic process
regulation of the force of heart contraction
adaptive immune response
CD8-positive, alpha-beta T cell differentiation involved in immune response
apoptotic process
movement of cell or subcellular component
humoral immune response
cell surface receptor signaling pathway
positive regulation of cell proliferation
response to virus
positive regulation of gene expression
negative regulation of gene expression
antigen processing and presentation
neutrophil chemotaxis
negative regulation of epithelial cell differentiation
endoplasmic reticulum unfolded protein response
negative regulation of myelination
positive regulation of synaptic transmission, cholinergic
positive regulation of tumor necrosis factor production
positive regulation of T cell proliferation
response to drug
positive regulation of tyrosine phosphorylation of Stat1 protein
defense response to bacterium
defense response to protozoan
negative regulation of growth of symbiont in host
positive regulation of interleukin-12 biosynthetic process
positive regulation of MHC class II biosynthetic process
positive regulation of interleukin-6 biosynthetic process
positive regulation of neuron differentiation
positive regulation of isotype switching to IgG isotypes
positive regulation of interleukin-1 beta secretion
T cell receptor signaling pathway
sensory perception of mechanical stimulus
regulation of interferon-gamma-mediated signaling pathway
positive regulation of vitamin D biosynthetic process
cellular response to lipopolysaccharide
cellular response to interleukin-18
positive regulation of establishment of protein localization to plasma membrane
regulation of neuronal action potential
positive regulation of exosomal secretion
regulation of hepatocyte proliferation
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