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Product Details
PA5-120652
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 470-557 of human IFNAR1 (NP_000620.2).
Conjugate
Form
Liquid
Concentration
2.6 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914224
Product Specific Information
Positive test controls include: SP2/0, A-549, Mouse brain. The target is usually found in the following locations: Membrane, Single-pass type I membrane protein.
Immunogen sequence: PSLKPSSSID EYFSEQPLKN LLLSTSEEQI EKCFIIENIS TIATVEETNQ TDEDHKKYSS QTSQDSGNYS NEDESESKTS EELQQDFV
Target Information
Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron,2001, Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-& Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-type antiviral protein; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; H3K1; IFN R1; IFN-alpha/beta receptor 1; IFN-alpha/betaR; IFN-alpha/betaR1; IFN-alpha/betaRalpha; IFN-R-1; IFNalpha/beta R1; IFNalpha/beta-Ralpha; IFNalpha/betaR1; IFNR1; INF-a receptor; interferon (alpha and beta) receptor 1; interferon (alpha, beta and omega) receptor 1; Interferon alpha/beta receptor 1; interferon receptor 1; interferon-alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; Type I interferon receptor 1
Gene Aliases: AVP; CD118; Ifar; IFN-alpha-REC; IFNAR; IFNAR1; IFNBR; IFRC; Infar
UniProt ID: (Human) P17181, (Mouse) P33896
Entrez Gene ID: (Human) 3454, (Rat) 288264, (Mouse) 15975
JAK-STAT cascade
response to virus
response to lipopolysaccharide
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
cellular response to interferon-alpha
T cell activation
type I interferon biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of interleukin-1 beta secretion
regulation of peptidyl-tyrosine phosphorylation
defense response to virus
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
biological_process
cytokine-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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