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Product Details
H00003455-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IFNAR2 (AAH02793.1, 1 a.a. approximately 331 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLLSQNAFIV RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL RQGLTKGWNA VAIHRCSHNA LQSETPELKQ SSCLSFPSSW DYKRASLCPS D
Target Information
The type I interferons, IFN-alpha and IFN-beta, are a group of structurally and functionally related proteins that are induced by either viruses or double-stranded RNA and are defined by their ability to confer an antiviral state in cells. IFN-alpha and IFN-beta appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN-gamma) binds to a distinct receptor. This distinct receptor, IFN-alphaR, is only weakly responsive to type I interferons, in contrast to IFN-alpha/betaR, which binds to and responds effectively to IFN-beta and to several of the IFN-alpha subtypes. IFN-alpha/betaR is expressed as two alternatively spliced transcripts, designated IFN-alpha/betaRalpha (IFN-alpha/betaR1) and IFN-alpha/betaRbeta (IFN-alpha/betaR2), both of which are involved in signal transduction and ligand binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human interferon alpha/beta receptor; IFN alpha/betaRbeta; IFN R2; IFN-alpha/beta receptor 2; IFN-alpha/betaR2; IFN-alpha/betaRbeta; IFN-R-2; IFNalpha/beta R2; IFNalpha/beta-Rbeta; IFNalpha/betaR2; IFNR2; interferon (alpha, beta and omega) receptor 2; Interferon alpha binding protein; Interferon alpha/beta receptor 2; interferon-alpha/beta receptor beta chain; Type I interferon receptor 2
Gene Aliases: IFN-alpha-REC; IFN-R; IFNABR; IFNAR2; IFNARB; IMD45
UniProt ID: (Human) P48551
Entrez Gene ID: (Human) 3455
regulation of transcription from RNA polymerase II promoter
cell surface receptor signaling pathway
JAK-STAT cascade
cell proliferation
response to virus
response to interferon-alpha
response to interferon-beta
defense response to virus
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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