Proteintech

IFNGR1 Polyclonal Antibody

IFNGR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IFNGR1 Antibody (10808-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 10808-1-AP ( IFNGR1 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

IFNGR1 Antibody in Flow Cytometry (Flow)

IFNGR1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10808-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IFNGR1 Fusion Protein Ag1114 (189-489 aa encoded by BC005333)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TQKEDDCDE IQCQLAIPVS SLNSQYCVSA EGVLHVWGVT TEKSKEVCIT IFNSSIKGSL WIPVVAALLL FLVLSLVFIC FYIKKINPLK EKSIILPKSL ISVVRSATLE TKPESKYVSL ITSYQPFSLE KEVVCEEPLS PATVPGMHTE DNPGKVEHTE ELSSITEVVT TEENIPDVVP GSHLTPIERE SSSPLSSNQS EPGSIALNSY HSRNCSESDH SRNGFDTDSS CLESHSSLSD SEFPPNNKGE IKTEGQELIT VIKAPTSFGY DKPHVLVDLL VDDSGKESLI GYRPTEDSKE FS (189-489 aa encoded by BC005333)

Target Information

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer.

Cell reports. Medicine

Alburquerque-Bejar JJ,Navajas-Chocarro P,Saigi M,Ferrero-Andres A,Morillas JM,Vilarrubi A,Gomez A,Mate JL,Munoz-Marmol AM,Romero OA,Blecua P,Davalos V,Esteller M,Pros E,Llabata P,Torres-Diz M,Esteve-Codina A,Sanchez-Cespedes M

Tue Apr 18 00:00:00 EDT 2023

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.

Journal of nanobiotechnology

Sha X,Dai Y,Chong L,Wei M,Xing M,Zhang C,Li J

Thu Dec 01 00:00:00 EST 2022

Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells.

Developmental cell

Parmigiani E,Ivanek R,Rolando C,Hafen K,Turchinovich G,Lehmann FM,Gerber A,Brkic S,Frank S,Meyer SC,Wakimoto H,Günel M,Louvi A,Mariani L,Finke D,Holländer G,Hutter G,Tussiwand R,Taylor V,Giachino C

Mon Aug 08 00:00:00 EDT 2022

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis.

Molecular therapy oncolytics

Qu S,Jiao Z,Lu G,Xu J,Yao B,Wang T,Wang J,Yao Y,Yan X,Wang T,Liang H,Zen K

Thu Jun 16 00:00:00 EDT 2022

DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion.

Nature communications

Chen B,Hu J,Hu X,Chen H,Bao R,Zhou Y,Ye Y,Zhan M,Cai W,Li H,Li HB

Tue Apr 19 00:00:00 EDT 2022

Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation.

Cancer discovery

Du W,Hua F,Li X,Zhang J,Li S,Wang W,Zhou J,Wang W,Liao P,Yan Y,Li G,Wei S,Grove S,Vatan L,Zgodziński W,Majewski M,Wallner G,Chen H,Kryczek I,Fang JY,Zou W

Thu Jul 01 00:00:00 EDT 2021

Impact of adipose tissue or umbilical cord derived mesenchymal stem cells on the immunogenicity of human cord blood derived endothelial progenitor cells.

PloS one

Tan K,Zheng K,Li D,Lu H,Wang S,Sun X

Tue Sep 26 00:00:00 EDT 2017

Impact of adipose tissue or umbilical cord derived mesenchymal stem cells on the immunogenicity of human cord blood derived endothelial progenitor cells.

PloS one

Tan K,Zheng K,Li D,Lu H,Wang S,Sun X

Tue Sep 26 00:00:00 EDT 2017

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.

The Journal of biological chemistry

Kroczynska B,Blyth GT,Rafidi RL,Majchrzak-Kita B,Xu L,Saleiro D,Kosciuczuk EM,Jemielity J,Su B,Altman JK,Eklund EA,Fish EN,Platanias LC

Fri Mar 17 00:00:00 EDT 2017

Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.

The Journal of biological chemistry

Kroczynska B,Blyth GT,Rafidi RL,Majchrzak-Kita B,Xu L,Saleiro D,Kosciuczuk EM,Jemielity J,Su B,Altman JK,Eklund EA,Fish EN,Platanias LC

Fri Mar 17 00:00:00 EDT 2017

Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes.

Journal of neuropathology and experimental neurology

Rodriguez FJ,Giannini C,Asmann YW,Sharma MK,Perry A,Tibbetts KM,Jenkins RB,Scheithauer BW,Anant S,Jenkins S,Eberhart CG,Sarkaria JN,Gutmann DH

Mon Dec 01 00:00:00 EST 2008

Journal of neuropathology and experimental neurology

Rodriguez FJ,Giannini C,Asmann YW,Sharma MK,Perry A,Tibbetts KM,Jenkins RB,Scheithauer BW,Anant S,Jenkins S,Eberhart CG,Sarkaria JN,Gutmann DH

Mon Dec 01 00:00:00 EST 2008

Bioinformatics

Protein Aliases: antiviral protein, type 2; AVP, type 2; CD119; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; immune interferon receptor 1; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain; interferon-gamma receptor alpha chain

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Gene Aliases: CD119; IFNGR; IFNGR1; IMD27A; IMD27B

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UniProt ID: (Human) P15260

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Entrez Gene ID: (Human) 3459

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Function(s)

interferon-gamma receptor activity protein binding interleukin-20 binding transmembrane signal receptor

Process(es)

signal transduction response to virus interferon-gamma-mediated signaling pathway regulation of interferon-gamma-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IFNGR1 Polyclonal Antibody

IFNGR1 Antibody (10808-1-AP) in IHC (P)

Product Details

10808-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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