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This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
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Protein Aliases: antiviral protein, type 2; AVP, type 2; CD119; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; immune interferon receptor 1; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain; interferon-gamma receptor alpha chain
Gene Aliases: CD119; IFNGR; IFNGR1; IMD27A; IMD27B
UniProt ID: (Human) P15260
Entrez Gene ID: (Human) 3459
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