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Product Details
MA1-21541
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2C8
Immunogen
Purified human placental IGF-1 receptors
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_559580
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IGF1 (Insulin-like growth factor-1) is structurally and functionally related to insulin but has a much higher growth-promoting activity. A variety of cellular responses are induced by IGF1, including cell proliferation, differentiation, migration, and survival. Further, IGF1 is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types in muscle, bone, and cartilage tissue. IGF1 stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regards to enhancing glucose uptake. In circulation, IGFs are predominantly bound to binding proteins (IGFBPs) which prolong the half-life of the IGFs and play a role in delivering them to target tissues. IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of proliferation and an inhibitor of programmed cell death. Moreover, mature human IGF-I is 100% homologous with bovine and porcine proteins. Low levels of IGF1 have been linked to Alzheimer's disease. IGF1 is processed from a precursor, bound by a specific receptor, and secreted. Defects in the IGF1 gene are a cause of insulin-like growth factor 1 deficiency and several transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: H-IGF-1; IGF; IGF-I; IGF-IA; IGF-IB; IGF1A; IGFIa; Insulin like growth factor; insulin-like growth factor 1 (somatomedin C); Insulin-like growth factor I; insulin-like growth factor IB; M-IGF-1; Mechano growth factor; MGF; OTTHUMP00000195084; R-IGF-1; Somatomedin C; Somatomedin-C
Gene Aliases: IBP1; IGF-I; IGF1; IGFI; MGF
UniProt ID: (Human) P05019
Entrez Gene ID: (Human) 3479
activation of MAPK activity
skeletal system development
response to hypoxia
cell activation
platelet degranulation
DNA replication
regulation of translation
movement of cell or subcellular component
signal transduction
Ras protein signal transduction
muscle organ development
female pregnancy
aging
response to nutrient
memory
cell proliferation
positive regulation of cell proliferation
response to heat
glycolate metabolic process
regulation of gene expression
positive regulation of glycoprotein biosynthetic process
positive regulation of cardiac muscle hypertrophy
phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
muscle hypertrophy
myotube cell development
positive regulation of smooth muscle cell migration
proteoglycan biosynthetic process
positive regulation of cell migration
response to caffeine
activation of protein kinase B activity
response to lipopolysaccharide
cellular response to insulin stimulus
positive regulation of protein import into nucleus, translocation
negative regulation of smooth muscle cell apoptotic process
response to nicotine
bone mineralization involved in bone maturation
regulation of multicellular organism growth
positive regulation of activated T cell proliferation
positive regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation of MAPK cascade
protein kinase B signaling
positive regulation of insulin-like growth factor receptor signaling pathway
cellular protein metabolic process
myoblast differentiation
positive regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
positive regulation of Ras protein signal transduction
insulin-like growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of protein secretion
positive regulation of peptidyl-tyrosine phosphorylation
protein stabilization
detection of mechanical stimulus involved in sensory perception
response to glucocorticoid
myoblast proliferation
regulation of calcium ion transport
negative regulation of oocyte development
positive regulation of cell growth involved in cardiac muscle cell development
ERK1 and ERK2 cascade
positive regulation of calcineurin-NFAT signaling cascade
cellular response to electrical stimulus
cellular response to estradiol stimulus
negative regulation of release of cytochrome c from mitochondria
negative regulation of neuron death
positive regulation of trophectodermal cell proliferation
negative regulation of cholangiocyte apoptotic process
positive regulation of transcription regulatory region DNA binding
negative regulation of extrinsic apoptotic signaling pathway
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