Proteintech

IGF2BP1 Polyclonal Antibody

View all (16) IGF2BP1 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (22)

IGF2BP1 Antibody in Immunocytochemistry (ICC/IF)

IGF2BP1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 22

IGF2BP1 Antibody (22803-1-AP) in ICC/IF

Immunofluorescent analysis of A375 cells using 22803-1-AP (IGF2BP1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

IGF2BP1 Antibody in Immunocytochemistry (ICC/IF)

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Western Blot (WB)

IGF2BP1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

IGF2BP1 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of A375 cells using 22803-1-AP (IGF2BP1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue slide using (Product # 22803-1-AP) IGF2BP1 antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue slide using (Product # 22803-1-AP) IGF2BP1 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human testis slide using 22803-1-AP ( IGF2BP1 Antibody) at dilution of 1:50.

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human testis slide using 22803-1-AP (IGF2BP1 Antibody) at dilution of 1:50.

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney slide using 22803-1-AP (IGF2BP1 Antibody) at dilution of 1:50.

IGF2BP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney slide using 22803-1-AP (IGF2BP1 Antibody) at dilution of 1:50.

IGF2BP1 Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with (Product # 22803-1-AP) IGF2BP1 antibody at dilution of 1:20,000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — Rat kidney tissue were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — Jurkat cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — Jurkat cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — Jurkat cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — A375 cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — HuH-7 cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 22803-1-AP (IGF2BP1 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

IGF2BP1 Antibody in Western Blot (WB) — WB result of IGF2BP1 antibody (22803-1-AP; 1:6000; incubated at room temperature for 1.5 hours) with sh-Control and sh-IGF2BP1 transfected Jurkat cells.

IGF2BP1 Antibody in Immunoprecipitation (IP) — IP result of anti-IGF2BP1 (IP:22803-1-AP, 4ug; Detection:22803-1-AP 1:1000) with HEK-293 cells lysate 1480ug.

Product Details

22803-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 41 publications 41 publications

Immunohistochemistry (IHC)

-

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

-

Immunocytochemistry (ICC/IF)

1:20-1:200

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

RNA Immunoprecipitation (RIP)

-

View 8 publications 8 publications

Not applicable (N/A)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IGF2BP1 Fusion Protein Ag18859 (126-198 aa encoded by BC156957)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YSNREQTRQ AIMKLNGHQL ENHALKVSYI PDEQIAQGPE NGRRGGFGSR GQPRQGSPVA AGAPAKQQQV DIPL (126-198 aa encoded by B C156957)

Target Information

IGF2BP1 is a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.

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Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.

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Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.

International journal of biological sciences

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Wed Feb 15 00:00:00 EST 2023

Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.

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N⁶-methyladenosine (m⁶A) reader IGF2BP1 facilitates clear-cell renal cell carcinoma aerobic glycolysis.

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N⁶-methyladenosine (m⁶A) reader IGF2BP1 facilitates clear-cell renal cell carcinoma aerobic glycolysis.

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PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer.

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TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.

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Wang H,Wei W,Zhang ZY,Liu Y,Shi B,Zhong W,Zhang HS,Fang X,Sun CL,Wang JB,Liu LX

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TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.

Cell death & disease

Wang H,Wei W,Zhang ZY,Liu Y,Shi B,Zhong W,Zhang HS,Fang X,Sun CL,Wang JB,Liu LX

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Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.

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He RZ,Jiang J,Hu X,Lei M,Li J,Luo W,Duan L,Hu Z,Mo YY,Luo DX,Peng WX

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Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.

Cancer cell international

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Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation.

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EGR2-mediated regulation of m⁶A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization.

Cell death & disease

Ying Y,Ma X,Fang J,Chen S,Wang W,Li J,Xie H,Wu J,Xie B,Liu B,Wang X,Zheng X,Xie L

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EGR2-mediated regulation of m⁶A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization.

Cell death & disease

Ying Y,Ma X,Fang J,Chen S,Wang W,Li J,Xie H,Wu J,Xie B,Liu B,Wang X,Zheng X,Xie L

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An in vitro system to silence mitochondrial gene expression.

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Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress.

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METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.

Aging

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Tue Oct 05 00:00:00 EDT 2021

Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation.

Journal of cellular and molecular medicine

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Fri May 01 00:00:00 EDT 2020

mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.

Journal of cellular and molecular medicine

Zhu MJ,Liu BY,Shi L,Wang X,Wang Y

Thu Oct 01 00:00:00 EDT 2020

mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.

Journal of cellular and molecular medicine

Zhu MJ,Liu BY,Shi L,Wang X,Wang Y

Thu Oct 01 00:00:00 EDT 2020

A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA.

Cancer letters

He J,Zuo Q,Hu B,Jin H,Wang C,Cheng Z,Deng X,Yang C,Ruan H,Yu C,Zhao F,Yao M,Fang J,Gu J,Zhou J,Fan J,Qin W,Yang XR,Wang H

Tue May 28 00:00:00 EDT 2019

PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α.

Journal of experimental & clinical cancer research : CR

Hou P,Chen F,Yong H,Lin T,Li J,Pan Y,Jiang T,Li M,Chen Y,Song J,Zheng J,Bai J

Wed Jul 10 00:00:00 EDT 2019

The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.

Nature communications

Li Z,Zhang J,Liu X,Li S,Wang Q,Hu Z,Yu T,Ding J,Li J,Yao M,Fan J,Huang S,Gao Q,Zhao Y,He X

Fri Apr 20 00:00:00 EDT 2018

The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.

Nature communications

Li Z,Zhang J,Liu X,Li S,Wang Q,Hu Z,Yu T,Ding J,Li J,Yao M,Fan J,Huang S,Gao Q,Zhao Y,He X

Fri Apr 20 00:00:00 EDT 2018

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.

Nucleic acids research

Panda AC,Grammatikakis I,Kim KM,De S,Martindale JL,Munk R,Yang X,Abdelmohsen K,Gorospe M

Thu Apr 20 00:00:00 EDT 2017

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.

Nucleic acids research

Panda AC,Grammatikakis I,Kim KM,De S,Martindale JL,Munk R,Yang X,Abdelmohsen K,Gorospe M

Thu Apr 20 00:00:00 EDT 2017

MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1.

The Journal of biological chemistry

Wang RJ,Li JW,Bao BH,Wu HC,Du ZH,Su JL,Zhang MH,Liang HQ

Fri Apr 03 00:00:00 EDT 2015

MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1.

The Journal of biological chemistry

Wang RJ,Li JW,Bao BH,Wu HC,Du ZH,Su JL,Zhang MH,Liang HQ

Fri Apr 03 00:00:00 EDT 2015

MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1.

The Journal of biological chemistry

Wang RJ,Li JW,Bao BH,Wu HC,Du ZH,Su JL,Zhang MH,Liang HQ

Fri Apr 03 00:00:00 EDT 2015

MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1.

The Journal of biological chemistry

Wang RJ,Li JW,Bao BH,Wu HC,Du ZH,Su JL,Zhang MH,Liang HQ

Fri Apr 03 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: B-actin zipcode-binding protein 1; coding region determinant binding protein; Coding region determinant-binding protein; CRD-BP; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; insulin-like growth factor 2 binding protein 1; insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP; Insulin-like growth factor 2 mRNA-binding protein 1; insulin-like growth factor 2, binding protein 1; rZBP-1; VICKZ family member 1; VIon ChannelKZ1; ZBP-1; ZBP1; zipcode binding protein 1; Zipcode-binding protein 1; zipcode-binding protein-1

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Gene Aliases: AL024068; AW549074; CRD-BP; CRDBP; D030026A21Rik; D11Moh40e; D11Moh45; IGF2BP1; IMP-1; IMP1; mir-3063; Neilsen; VICKZ1; ZBP-1; ZBP1

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UniProt ID: (Human) Q9NZI8, (Mouse) O88477, (Rat) Q8CGX0

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Entrez Gene ID: (Human) 10642, (Mouse) 140486, (Rat) 303477

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nucleotide binding mRNA binding mRNA 3'-UTR binding protein binding poly(A) RNA binding translation regulator activity mRNA 5'-UTR binding nucleic acid binding RNA binding RNA metabolism protein

Process(es)

gene expression regulation of mRNA stability involved in response to stress negative regulation of translation pallium cell proliferation in forebrain regulation of cytokine biosynthetic process mRNA transport CRD-mediated mRNA stabilization neuronal stem cell population maintenance RNA localization regulation of translation transport

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