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IGF2BP1 Antibody (PA5-89310) in WB
Western blot analysis of IGF2BP1 in extracts of various cell lines. Samples were incubated with IGF2BP1 Polyclonal antibody (Product # PA5-89310) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product Details
PA5-89310
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 478-577 of human IGF2BP1/IMP1 (NP_0065373)
Conjugate
Form
Liquid
Concentration
1.59 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805483
Product Specific Information
Positive Samples: Jurkat, K-562, HepG2, HeLa, NIH/3T3, A-549, HL-60, Mouse liver; Cellular Location: Cell projection, Cytoplasm, Nucleus, axon, dendrite, dendritic spine, filopodium, growth cone, lamellipodium, perinuclear region
Immunogen sequence: NFFGPKEEVK LETHIRVPAS AAGRVIGKGG KTVNELQNLT AAEVVVPRDQ TPDENDQVIV KIIGHFYASQ MAQRKIRDIL AQVKQQHQKG QSNQAQARRK
Target Information
IGF2BP1 is a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-actin zipcode-binding protein 1; coding region determinant binding protein; Coding region determinant-binding protein; CRD-BP; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; insulin-like growth factor 2 binding protein 1; insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP; Insulin-like growth factor 2 mRNA-binding protein 1; insulin-like growth factor 2, binding protein 1; rZBP-1; VICKZ family member 1; VIon ChannelKZ1; ZBP-1; ZBP1; zipcode binding protein 1; Zipcode-binding protein 1; zipcode-binding protein-1
Gene Aliases: AL024068; AW549074; CRD-BP; CRDBP; D030026A21Rik; D11Moh40e; D11Moh45; IGF2BP1; IMP-1; IMP1; mir-3063; Neilsen; VICKZ1; ZBP-1; ZBP1
UniProt ID: (Human) Q9NZI8, (Mouse) O88477, (Rat) Q8CGX0
Entrez Gene ID: (Human) 10642, (Mouse) 140486, (Rat) 303477
gene expression
regulation of mRNA stability involved in response to stress
negative regulation of translation
pallium cell proliferation in forebrain
regulation of cytokine biosynthetic process
mRNA transport
CRD-mediated mRNA stabilization
neuronal stem cell population maintenance
RNA localization
regulation of translation
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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