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Invitrogen
IGF2BP1 Recombinant Rabbit Monoclonal Antibody (18H5L31)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
IGF2BP1 Antibody (703103) in ICC/IF
For immunofluorescence analysis, HeLa cells were fixed and permeabilized for detection of endogenous IGF2BP1 using Anti-IGF2BP1 Recombinant Rabbit Monoclonal Antibody (Product # 703103, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of IGF2BP1 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with DAPI (... View More
Product Details
703103
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
18H5L31
Immunogen
Peptides corresponding to human IGF2BP1 [(aa162-aa178) (aa561-aa577)]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2784560
Product Specific Information
This antibody is predicted to react with Monkey, Dog, Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
IGF2BP1 is a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coding region determinant binding protein; Coding region determinant-binding protein; CRD-BP; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP; Insulin-like growth factor 2 mRNA-binding protein 1; insulin-like growth factor 2, binding protein 1; VICKZ family member 1; VIon ChannelKZ1; ZBP-1; zipcode binding protein 1; Zipcode-binding protein 1
Gene Aliases: AL024068; AW549074; CRD-BP; CRDBP; D030026A21Rik; D11Moh40e; D11Moh45; IGF2BP1; IMP-1; IMP1; mir-3063; Neilsen; VICKZ1; ZBP-1; ZBP1
UniProt ID: (Human) Q9NZI8, (Mouse) O88477
Entrez Gene ID: (Human) 10642, (Mouse) 140486
gene expression
regulation of mRNA stability involved in response to stress
negative regulation of translation
pallium cell proliferation in forebrain
regulation of cytokine biosynthetic process
mRNA transport
CRD-mediated mRNA stabilization
neuronal stem cell population maintenance
RNA localization
regulation of translation
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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