Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Positive test controls include: 293T, MCF7. The target is usually found in the following locations: Membrane, Single-pass type I membrane protein.
Immunogen sequence: KVAKESDSVF VLKIYHLRQE DSGKYNCRVT EREKTVTGEF IDKESKRPKN IPIIVLPLKS SISVEVASNA SVILEGEDLR FSCSVRTAGR PQGRFSVIWQ LVDRQNRRSN IMWLDRDGTV QPGSSYWERS SFGGVQMEQV QPNSFSLGIF NSRKEDEGQY ECHVTEWVRA VDGEWQIVGE RRASTPISIT ALEMGFAVTA ISRTPGVTYS DSF
IGSF3 (immunoglobulin superfamily, member 3), also known as V8 or EWI-3, is a 1,214 amino acid protein. Widely expressed with predominant expression in kidney, placenta and lung, IGSF3 localizes to the membrane and contains an N-terminal signal peptide, eight immunoglobulin (Ig) domains and a transmembrane segment. IGSF3 exhibits strong sequence and structural similarity to CD101 (32% identity), a leukocyte surface protein with seven Ig domains that is believed to play a role in T-cell activation. Despite the structural similarities between IGSF3 and CD101, IGSF3 is not expressed in peripheral blood lymphocytes and does not appear to participate in an immune function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EWI-3; Glu-Trp-Ile EWI motif-containing protein 3; IgSF3; immunoglobin superfamily, member 3; Immunoglobulin superfamily member 3; RP4-781D12.1
Gene Aliases: EWI-3; EWI3; IGSF3; KIAA0466; LCDD; V8
UniProt ID: (Human) O75054
Entrez Gene ID: (Human) 3321
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