Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MLGMGCWAR EVLVPEGPLY RVAGTAVSIS CNVTGYEGPA QQNFEWFLYR PEAPDTALGI VSTKDTQFSY AVFKSRVVAG EVQVQRLQGD AVVLKIARLQ AQDAGIYECH TPSTDTRYLG SYSGKVELRV LPDVLQVSAA PPGPRGRQAP TSPPRMTVHE GQELALGCLA RTSTQKHTHL AVSFGRSVPE APVGRSTLQE VVGIRSDLAV EAGAPYAERL AAGELRLGKE GTDRYRMVVG GAQAGDAGTY HCTAAEWIQD PDGSWAQIAE KRAVLAHVDV QTLSSQLAVT VGPGERRIGP GEPLELLCNV SGALPPAGRH AAYSVGWEMA PA (20-350 aa encoded by BC053881)
This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD316; CD81 partner 3; EWI-2; Glu-Trp-Ile EWI motif-containing protein 2; IgSF8; Immunoglobulin superfamily member 8; immunoglobulin superfamily, member 8; KCT-4; Keratinocyte-associated transmembrane protein 4; Keratinocytes-associated transmembrane protein 4; LIR-D1; PG regulatory-like protein; PGRL; Prostaglandin regulatory-like protein
Gene Aliases: AA033172; AU041109; CD316; CD81P3; ESTM34; EWI-2; EWI2; IGSF8; KCT-4; KCT4; LIR-D1; PGRL; R75384
UniProt ID: (Human) Q969P0, (Mouse) Q8R366
Entrez Gene ID: (Human) 93185, (Mouse) 140559, (Rat) 304979
Molecular Function:
immunoglobulin receptor superfamily
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support