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GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: interferon-gamma-inducible GTPase Ifgga1 protein; Interferon-inducible GTPase 1
Gene Aliases: 2900074L10Rik; AI046432; AW111922; Ifgga1; Iigp; Iigp1; Irga6
UniProt ID: (Mouse) Q9QZ85
Entrez Gene ID: (Mouse) 60440
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