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Product Details
H00003551-M04
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1A3
Immunogen
IKBKB (AAH06231, 3 a.a. approximately 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: WSPSLTTQTC GAWEMKERLG TGGFGNVIRW HNQETGEQIA IKQCRQELSP RNRERWCLEI QIMRRLTHPN VVAARDVPEG MQNLAPNDLP LLAMEYCQGG DLRKYLNQFE NCCGLREG
Target Information
Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex. Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-2; IKK-B; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB
Gene Aliases: IKBKB; IKK-beta; IKK2; IKKB; IMD15; NFKBIKB
UniProt ID: (Human) O14920
Entrez Gene ID: (Human) 3551
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
IkappaB kinase activity
protein kinase binding
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
stimulatory C-type lectin receptor signaling pathway
skeletal muscle contraction
protein phosphorylation
inflammatory response
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation
positive regulation of cell proliferation
response to virus
response to toxic substance
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of neuron projection development
cortical actin cytoskeleton organization
neuron projection development
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
negative regulation of myosin-light-chain-phosphatase activity
TRIF-dependent toll-like receptor signaling pathway
Fc-epsilon receptor signaling pathway
regulation of phosphorylation
response to drug
serine phosphorylation of STAT protein
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
nucleotide-binding oligomerization domain containing signaling pathway
interleukin-1-mediated signaling pathway
response to fatty acid
cellular response to tumor necrosis factor
establishment of protein localization to plasma membrane
positive regulation of neuron death
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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