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Immunogen sequence: MSEVKSRKK SGPKGAPAAE PGKRSEGGKT PVARSSGGGG WADPRTCLSL LSLGTCLGLA WFVFQQSEKF AKVENQYQLL KLETNEFQQL QSKISLISEK LESTESILQE ATSSMSLMTQ FEQEVSNLQD IMHDIQNNEE VLTQRMQSLN EKFQNITDFW KRSLEEMNIN TDIFKSEAKH IHSQVTVQIN SAEQEIKLLT ERLKDLEDST LRNIRTVKRQ EEEDLLRVEE QLGSDTKAIE KLEEEQHALF ARDEDLTNKL SDYEPKVEEC KTHLPTIESA IHSVLRVSQD LIETEKKMED LTMQMFNMED DMLKAVSEIM EMQKTLEGIQ YDNSILKMQN ELDILKEKVH DFIAYSSTGE KGTLKEYNIE NKGIGGDF (1-377 aa encoded by BC058933)
IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle.
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Protein Aliases: I kappa B kinase interacting protein; i kappa-B kinase interacting protein; I kappa-B kinase-interacting protein; IKBKB-interacting protein; IKK interacting protein; IKK-interacting protein; Inhibitor of nuclear factor kappa-B kinase-interacting protein
Gene Aliases: 1200009F10Rik; 1700023M03Rik; D18354; IKBIP; IKIP
UniProt ID: (Human) Q70UQ0, (Mouse) Q9DBZ1
Entrez Gene ID: (Human) 121457, (Mouse) 67454
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