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Invitrogen
IKK alpha Monoclonal Antibody (14A231)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 6
IKK alpha Antibody (MA5-16157) in IHC (P)
Immunohistochemical analysis of IKK alpha in formalin-fixed paraffin-embedded tissue section of human kidney. Samples were incubated in IKK alpha monoclonal antibody (Product # MA5-16157) using a dilution of 1:200 followed by HRP labeled anti-rabbit secondary antibody and DAB reagent. Nuclei of cells were counter-stained with hematoxylin.
Product Details
MA5-16157
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
14A231
Immunogen
His-tagged full-length human IKK alpha protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2537676
Product Specific Information
Suggested positive control: Daudi, NIH-3T3, or Raw.
Target Information
CHUK (IKK alpha) is a serine/threonine kinase involved in signal transduction and cellular communication. It belongs to the cytokine activated protein complex that is an inhibitor of the NF-kappa B complex. IKK alpha along with IKK beta and a regulatory protein NEMO (IKK gamma) phosphorylates IkB proteins which targets the later for ubiquitin mediated degradation. It is involved with several cellular processes with extensive studies on its role in inflammation and cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; FLJ40509; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; ikappaB kinase; IkappaB kinase alpha; IkB kinase alpha subunit; IKBKB; IKK alpha; IKK-1; IKK-A; IKK-a kinase; IKK-B; IKK-beta; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit alpha; kinase beta; MGC131801; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; Transcription factor 16
Gene Aliases: AI256658; CHUK; Chuk1; Fbx24; Fbxo24; IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
UniProt ID: (Human) O15111
Entrez Gene ID: (Human) 1147, (Mouse) 12675, (Rat) 309361
protein kinase activity
protein binding
ATP binding
IkappaB kinase activity
protein homodimerization activity
protein heterodimerization activity
scaffold protein binding
nucleotide binding
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
stimulatory C-type lectin receptor signaling pathway
skeletal muscle contraction
protein phosphorylation
inflammatory response
immune response
I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation
Rho protein signal transduction
response to virus
response to toxic substance
anatomical structure morphogenesis
response to acetate
regulation of tumor necrosis factor-mediated signaling pathway
response to lipopolysaccharide
response to hydroperoxide
TRIF-dependent toll-like receptor signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
response to drug
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to amino acid
innate immune response
positive regulation of transcription from RNA polymerase II promoter
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
striated muscle cell differentiation
stress-activated MAPK cascade
nucleotide-binding oligomerization domain containing signaling pathway
cellular response to tumor necrosis factor
morphogenesis of an epithelial sheet
lactation
response to organic substance
phosphorylation
signal transduction by protein phosphorylation
osteoclast differentiation
mammary gland epithelial cell proliferation
response to muscle stretch
odontogenesis of dentin-containing tooth
mammary gland alveolus development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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