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Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
The antiserum is directed against the extracellular domain of the human IL-1R type I, but precipitates the intact receptor expressed on human cells. In general, this antibody also detects primate IL-1RI. The antibody does not recognize human IL-1, IL-1Ra or IL-1R type II. In ELISA formats and other immunoreactive assays, this antibody will detect the extracellular domain of the IL-1R type I (also called soluble IL-1R type I or ''decoy'' receptor) found in human body fluids, particularly in the circulation, urine and supernatants of cells and synovial fluid.
The IL-1 system includes two agonists (IL-1 and IL-1), converting enzymes, antagonists, two receptors (IL-1 RI and IL-1 RII) and the IL-1 receptor accessory protein. Interleukin-1 signal is transduced through the type I receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antigen CD121a; CD121 alpha; CD121 antigen-like family member A; CD121a; il-1 receptor; il-1r; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; il1 receptor; interleukin 1 receptor alpha, type I; interleukin 1 receptor, type I; interleukin-1 receptor; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type I; p80
Gene Aliases: CD121A; D2S1473; IL-1R-alpha; IL1R; IL1R1; IL1RA; IL1RT1; P80
UniProt ID: (Human) P14778
Entrez Gene ID: (Human) 3554
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