Invitrogen

IL-1 beta Polyclonal Antibody

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

21 Published Figures

43 References

View all (119) IL-1 beta antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

IL-1 beta Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 25

IL-1 beta Antibody (P420B) in ICC/IF

Immunofluorescence analysis of Interleukin-1 beta was performed using 70% confluent log phase THP-1 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with IL-1 beta Polyclonal Antibody (Product # P420B) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsi... View More

IL-1 beta Antibody in Immunohistochemistry (IHC)

IL-1 beta Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

IL-1 beta Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IL-1 beta Antibody in Immunoprecipitation (IP)

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Product Details

P420B

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

View 12 publications 12 publications

Immunohistochemistry (IHC)

Assay-dependent

View 15 publications 15 publications

Immunohistochemistry (Paraffin) (IHC (P))

View 3 publications 3 publications

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

5 µg/mL

View 6 publications 6 publications

ELISA (ELISA)

Assay-dependent

View 2 publications 2 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Neutralization (Neu)

Assay-dependent

View 3 publications 3 publications

Affinity Purification (AP)

- -

Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Published species

Horse, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant human IL-1 beta

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_223478

Product Specific Information

P420B targets IL-1 beta in ELISA, IHC, Neu, and WB applications and shows reactivity with Human, mouse, and Non-human primate samples.

The P420B immunogen is recombinant human IL-1 beta.

P420B detects IL-1 beta which has a predicted molecular weight of approximately 31 kDa.

This product is a Low Endotoxin formulation.

This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).

Target Information

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1β/NF-κB pathway.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Sun C,Cao C,Zhao T,Guo H,Fleming BC,Owens B,Beveridge J,McAllister S,Wei L

P420B was used in ELISA, Immunocytochemistry, Immunohistochemistry, Neutralization, Western Blot to demonstrate a mechanism by which A2M reduces inflammatory catabolic activity and protects cartilage after joint injury.

Sun Jan 01 00:00:00 EST 2023

A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1β/NF-κB pathway.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Sun C,Cao C,Zhao T,Guo H,Fleming BC,Owens B,Beveridge J,McAllister S,Wei L

Sun Jan 01 00:00:00 EST 2023

Colonic oxygen microbubbles augment systemic oxygenation and CO₂ removal in a porcine smoke inhalation model of severe hypoxia.

Intensive care medicine experimental

Mountford PA,Leiphrakpam PD,Weber HR,McCain A,Scribner RM,Scribner RT,Duarte EM,Chen J,Noe D,Borden MA,Buesing KL

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Western Blot

Mon Jun 26 00:00:00 EDT 2023

Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells.

Toxins

Kozlovskiy SA,Pislyagin EA,Menchinskaya ES,Chingizova EA,Sabutski YE,Polonik SG,Likhatskaya GN,Aminin DL

P420B was used in Western Blotting to study the ability of 1,4-naphthoquinone thioglucoside derivatives, compounds U-286 and U-548, to inhibit inflammation induced by ATP/LPS in RAW 264.7 cells via P2X7 receptors.

Thu Jan 05 00:00:00 EST 2023

Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells.

Toxins

Kozlovskiy SA,Pislyagin EA,Menchinskaya ES,Chingizova EA,Sabutski YE,Polonik SG,Likhatskaya GN,Aminin DL

Thu Jan 05 00:00:00 EST 2023

Highly reproducible rat arterial injury model of neointimal hyperplasia.

PloS one

Tan RP,Hung JC,Chan AHP,Grant AJ,Moore MJ,Lam YT,Michael P,Wise SG

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Immunohistochemistry (Paraffin)

Mon Aug 21 00:00:00 EDT 2023

ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler's murine encephalomyelitis virus.

Scientific reports

Li D,Bühler M,Runft S,Gerold G,Marek K,Baumgärtner W,Strowig T,Gerhauser I

P420B was used in Immunohistochemistry to examine the role of the inflammasome pathway, specifically ASC and caspase-1, in C57BL/6 (B6) mice's resistance to TMEV-induced demyelinating disease (TMEV-IDD).

Thu Jul 06 00:00:00 EDT 2023

ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler's murine encephalomyelitis virus.

Scientific reports

Li D,Bühler M,Runft S,Gerold G,Marek K,Baumgärtner W,Strowig T,Gerhauser I

Thu Jul 06 00:00:00 EDT 2023

The Role of Gender Differences and Menopause in Obesity-Related Renal Disease, Renal Inflammation and Lipotoxicity.

International journal of molecular sciences

Afonso-Alí A,Porrini E,Teixido-Trujillo S,Pérez-Pérez JA,Luis-Lima S,Acosta-González NG,Sosa-Paz I,Díaz-Martín L,Rodríguez-González C,Rodríguez-Rodríguez AE

P420B was used in Immunohistochemistry to evaluated renal inflammation and lipotoxicity in that animal model.

Sat Aug 19 00:00:00 EDT 2023

Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling.

Nature neuroscience

Kumar P,Lim A,Hazirah SN,Chua CJH,Ngoh A,Poh SL,Yeo TH,Lim J,Ling S,Sutamam NB,Petretto E,Low DCY,Zeng L,Tan EK,Arkachaisri T,Yeo JG,Ginhoux F,Chan D,Albani S

P420B was used in Immunohistochemistry-immunofluorescence to provide insight into the immune microenvironment in epileptic tissue, which may aid the development of new therapeutics.

Fri Jul 01 00:00:00 EDT 2022

IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.

Molecular medicine reports

Li Y,Wang Y,Guo H,Wu Q,Hu Y

P420B was used in Western Blot to investigate the involvement of interferon regulatory factor 2 (IRF2) in myocardial infarction and the underlying mechanism of IRF2 in pyroptosis.

Tue Feb 01 00:00:00 EST 2022

IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.

Molecular medicine reports

Li Y,Wang Y,Guo H,Wu Q,Hu Y

P420B was used in Western Blot to investigate the involvement of interferon regulatory factor 2 (IRF2) in myocardial infarction and the underlying mechanism of IRF2 in pyroptosis.

Tue Feb 01 00:00:00 EST 2022

IRF2 contributes to myocardial infarction via regulation of GSDMD induced pyroptosis.

Molecular medicine reports

Li Y,Wang Y,Guo H,Wu Q,Hu Y

P420B was used in Western Blot to investigate the involvement of interferon regulatory factor 2 (IRF2) in myocardial infarction and the underlying mechanism of IRF2 in pyroptosis.

Tue Feb 01 00:00:00 EST 2022

Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia.

Journal of lipid research

Yuan X,Bhat OM,Zou Y,Li X,Zhang Y,Li PL

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Immunohistochemistry

Thu Dec 01 00:00:00 EST 2022

Flavonoid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents.

Antioxidants (Basel, Switzerland)

Yang BW,Yang S,Kim S,Baek AR,Sung B,Kim YH,Lee JT,Lee SY,Kim HK,Choi G,Park JA,Nam SW,Lee GH,Chang Y

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Western Blot

Thu Dec 15 00:00:00 EST 2022

Obese female mice do not exhibit overt hyperuricemia despite hepatic steatosis and impaired glucose tolerance.

Advances in redox research

Lewis SE,Li L,Fazzari M,Salvatore SR,Li J,Hileman EA,Maxwell BA,Schopfer FJ,Arteel GE,Khoo NKH,Kelley EE

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Western Blot

Thu Dec 01 00:00:00 EST 2022

Obese female mice do not exhibit overt hyperuricemia despite hepatic steatosis and impaired glucose tolerance.

Advances in redox research

Lewis SE,Li L,Fazzari M,Salvatore SR,Li J,Hileman EA,Maxwell BA,Schopfer FJ,Arteel GE,Khoo NKH,Kelley EE

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Western Blot

Thu Dec 01 00:00:00 EST 2022

Placental Inflammasome mRNA Levels Differ by Mode of Delivery and Fetal Sex.

Frontiers in immunology

Arthurs AL,Smith MD,Hintural MD,Breen J,McCullough D,Thornton FI,Leemaqz SY,Dekker GA,Jankovic-Karasoulos T,Roberts CT

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Western Blot

Tue Apr 12 00:00:00 EDT 2022

Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production.

Journal of applied microbiology

Yong W,Zhao Y,Jiang X,Li P

P420B was used in Immunohistochemistry to explore the effect of sodium butyrate (NaB) on PE using Nω-nitro-L-arginine methyl ester hydrochloride to induce PE in pregnant rats.

Tue Feb 01 00:00:00 EST 2022

Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked Hydroxy Groups.

Cancers

Lewińska A,Przybylski P,Adamczyk-Grochala J,Błoniarz D,Litwinienko G,Wnuk M

P420B was used in Immunocytochemistry-immunofluorescence to study targeted elimination of senescent cells using synthesized quercetin derivatives which were tested for improved senolytic action against etoposide-induced senescent human normal mammary epithelial cells and triple-negative breast cancer cells in vitro.

Tue Jan 25 00:00:00 EST 2022

Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis.

Antioxidants & redox signaling

Potor L,Hendrik Z,Patsalos A,Katona É,Méhes G,Póliska S,Csősz É,Kalló G,Komáromi I,Combi Z,Posta N,Sikura KÉ,Pethő D,Oros M,Vereb G,Tóth C,Gergely P,Nagy L,Balla G,Balla J

P420B was used in Immunohistochemistry to conclude that ferrylHb in atherosclerotic lesion provokes the progression of the disease via polarizing macrophages.

Wed Oct 20 00:00:00 EDT 2021

Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis.

Antioxidants & redox signaling

Potor L,Hendrik Z,Patsalos A,Katona É,Méhes G,Póliska S,Csősz É,Kalló G,Komáromi I,Combi Z,Posta N,Sikura KÉ,Pethő D,Oros M,Vereb G,Tóth C,Gergely P,Nagy L,Balla G,Balla J

P420B was used in Immunohistochemistry to conclude that ferrylHb in atherosclerotic lesion provokes the progression of the disease via polarizing macrophages.

Wed Oct 20 00:00:00 EDT 2021

Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis.

Antioxidants & redox signaling

Potor L,Hendrik Z,Patsalos A,Katona É,Méhes G,Póliska S,Csősz É,Kalló G,Komáromi I,Combi Z,Posta N,Sikura KÉ,Pethő D,Oros M,Vereb G,Tóth C,Gergely P,Nagy L,Balla G,Balla J

P420B was used in Immunohistochemistry to conclude that ferrylHb in atherosclerotic lesion provokes the progression of the disease via polarizing macrophages.

Wed Oct 20 00:00:00 EDT 2021

Exenatide Attenuates Non-Alcoholic Steatohepatitis by Inhibiting the Pyroptosis Signaling Pathway.

Frontiers in endocrinology

Liu Y,Wang DW,Wang D,Duan BH,Kuang HY

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Immunocytochemistry

Mon Dec 20 00:00:00 EST 2021

Sterile inflammation drives multiple programmed cell death pathways in the gut.

Journal of leukocyte biology

Ruera CN,Miculán E,Pérez F,Ducca G,Carasi P,Chirdo FG

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Western Blot

Fri Jan 01 00:00:00 EST 2021

Sterile inflammation drives multiple programmed cell death pathways in the gut.

Journal of leukocyte biology

Ruera CN,Miculán E,Pérez F,Ducca G,Carasi P,Chirdo FG

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Western Blot

Fri Jan 01 00:00:00 EST 2021

Equine cervical remodeling during placentitis and the prepartum period: a transcriptomic approach.

Reproduction (Cambridge, England)

El-Sheikh Ali H,Scoggin KE,Ruby R,Loynachan A,Boakari Y,Fernandes C,Dini P,Fedorka CE,Loux SC,Esteller-Vico A,Ball BA

P420B was used in Immunohistochemistry to investigate the molecular mechanisms underlying cervical remodeling.

Wed May 05 00:00:00 EDT 2021

Role of Inflammation and Redox Status on Doxorubicin-Induced Cardiotoxicity in Infant and Adult CD-1 Male Mice.

Biomolecules

Reis-Mendes A,Padrão AI,Duarte JA,Gonçalves-Monteiro S,Duarte-Araújo M,Remião F,Carvalho F,Sousa E,Bastos ML,Costa VM

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Western Blot

Fri Nov 19 00:00:00 EST 2021

Role of Inflammation and Redox Status on Doxorubicin-Induced Cardiotoxicity in Infant and Adult CD-1 Male Mice.

Biomolecules

Reis-Mendes A,Padrão AI,Duarte JA,Gonçalves-Monteiro S,Duarte-Araújo M,Remião F,Carvalho F,Sousa E,Bastos ML,Costa VM

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Western Blot

Fri Nov 19 00:00:00 EST 2021

Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s.

Scientific reports

Kong WS,Tsuyama N,Inoue H,Guo Y,Mokuda S,Nobukiyo A,Nakatani N,Yamaide F,Nakano T,Kohno Y,Ikeda K,Nakanishi Y,Ohno H,Arita M,Shimojo N,Kanno M

P420B was used in Immunohistochemistry to propose that early exposure to LCSFAs in infants may affect the balance of intestinal innate immunity.

Wed Jun 23 00:00:00 EDT 2021

Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s.

Scientific reports

Kong WS,Tsuyama N,Inoue H,Guo Y,Mokuda S,Nobukiyo A,Nakatani N,Yamaide F,Nakano T,Kohno Y,Ikeda K,Nakanishi Y,Ohno H,Arita M,Shimojo N,Kanno M

P420B was used in Immunohistochemistry to propose that early exposure to LCSFAs in infants may affect the balance of intestinal innate immunity.

Wed Jun 23 00:00:00 EDT 2021

The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence.

Aging

Bloniarz D,Adamczyk-Grochala J,Lewinska A,Wnuk M

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Immunocytochemistry

Thu Jun 17 00:00:00 EDT 2021

Transcriptional and Histochemical Signatures of Bone Marrow Mononuclear Cell-Mediated Resolution of Synovitis.

Frontiers in immunology

Menarim BC,El-Sheikh Ali H,Loux SC,Scoggin KE,Kalbfleisch TS,MacLeod JN,Dahlgren LA

P420B was used in Immunohistochemistry (Paraffin) to study differential transcriptional signatures of bone marrow mononuclear cells in response to normal and inflamed synovial fluid.

Thu Feb 10 00:00:00 EST 2022

Positive Allosteric Modulation of Alpha7 Nicotinic Acetylcholine Receptors Transiently Improves Memory but Aggravates Inflammation in LPS-Treated Mice.

Frontiers in aging neuroscience

Lykhmus O,Kalashnyk O,Uspenska K,Skok M

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in ELISA

Mon Sep 28 00:00:00 EDT 2020

p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine.

Frontiers in immunology

Gómez Castro MF,Miculán E,Herrera MG,Ruera C,Perez F,Prieto ED,Barrera E,Pantano S,Carasi P,Chirdo FG

P420B was used in Western Blotting to examine what drives the induction of inflammatory Th1 responses against harmless antigens in food.

Fri Dec 20 00:00:00 EST 2019

Dysregulated expression of antioxidant enzymes in polyethylene particle-induced periprosthetic inflammation and osteolysis.

PloS one

Peng KT,Tsai MH,Lee CW,Chiang YC,Chen PC,Chen CC,Chang CH,Shih HN,Chang PJ

P420B was used in Immunohistochemistry-immunofluorescence to assess the effects of polyethylene particles on the levels of oxidative stress markers in blood plasma, and on the expression profiles of antioxidant enzymes in knee joint tissues.

Mon Feb 04 00:00:00 EST 2019

Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye.

Journal of autoimmunity

Chi W,Hua X,Chen X,Bian F,Yuan X,Zhang L,Wang X,Chen D,Deng R,Li Z,Liu Y,de Paiva CS,Pflugfelder SC,Li DQ

Published figure using IL-1 beta polyclonal antibody (Product # P420B) in Immunofluorescence

Thu Jun 01 00:00:00 EDT 2017

Desiccating stress worsens alkali burn injury by magnifying caspase-8-induced imbalance of NLRP3 and NLRP6.

The Journal of allergy and clinical immunology

Hua X,Yuan X,Li Y,Chen H,Yuan J,Tanumiharjo S,Bian F,Su L,Hong Y,Liu Y,Chi W

P420B was used in Immunohistochemistry-immunofluorescence to explore the potential functions and mechanisms of innate immune response in certain diseases.

Sun Oct 01 00:00:00 EDT 2017

Distinct expression of interleukin-1α, interleukin-1β, and interleukin-1 receptor antagonist in testicular tissues and cells from human biopsies with normal and abnormal histology.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Abu Elheija M,Dyomin V,Ganaiem M,Lunenfeld E,Vardy NS,Huleihel M

P420B was used in immunohistochemistry to investigate the level of interleukin-1??, interleukin-1??, and interleukin-1 receptor antagonist in human testicular normal and abnormal biopsies

Fri Apr 01 00:00:00 EDT 2011

Perfusion with lipopolysaccharide differently affects the secretion of interleukin-1 beta and interleukin-1 receptor antagonist by term and preterm human placentae.

Placenta

Holcberg G,Amash A,Sapir O,Sheiner E,Levy S,Myatt L,Huleihel M

P420B was used in immunohistochemistry to study the secretion of IL-1beta and IL-1Ra by perfused term and preterm human placental tissue and the effects of LPS

Tue Jul 01 00:00:00 EDT 2008

Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection.

Proceedings of the National Academy of Sciences of the United States of America

Miura Y,Misawa N,Kawano Y,Okada H,Inagaki Y,Yamamoto N,Ito M,Yagita H,Okumura K,Mizusawa H,Koyanagi Y

P420B was used in immunohistochemistry to investigate the role of TRAIL expressed in HIV-1-infected macrophages on neuronal apoptosis

Tue Mar 04 00:00:00 EST 2003

Monocyte:astrocyte interactions regulate MCP-1 expression in both cell types.

Journal of leukocyte biology

Andjelkovic AV,Kerkovich D,Pachter JS

P420B was used in blocking or activating experiment to study the role of monocyte-astrocyte interactions in regulating MCP-1 expression in both cell types

Sun Oct 01 00:00:00 EDT 2000

Intrahepatic expression of interleukin-1beta and tumor necrosis factor-alpha in chronic hepatitis C.

The Journal of infectious diseases

Dumoulin FL,Leifeld L,Honecker U,Sauerbruch T,Spengler U

P420B was used in immunohistochemistry to investigate the intrahepatic expression of interleukin 1 beta and tumor necrosis factor alpha in liver specimens with chronic hepatitis C

Mon Nov 01 00:00:00 EST 1999

1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1beta production.

The Journal of clinical investigation

Peleg S,Qiu H,Reddy S,Harris D,Van Q,Estey EH,Talpaz M,Estrov Z

P420B was used in western blot to study the effect of 1,25-dihydroxyvitamin D3 on acute myelogenous leukemia progenitor proliferation and its mechanism

Wed Oct 01 00:00:00 EDT 1997

Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms.

The American journal of pathology

Waldburger KE,Hastings RC,Schaub RG,Goldman SJ,Leonard JP

P420B was used in immunohistochemistry to study the effect of interleukin 12 on experimental allergic encephalomyelitis

Thu Feb 01 00:00:00 EST 1996

Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt.

Journal of immunology (Baltimore, Md. : 1950)

Goebeler M,Roth J,Bröcker EB,Sorg C,Schulze-Osthoff K

P420B was used in blocking/activating experiment to investigate the effect of nickel chloride and cobalt chloride on the expression of NF-kappa B in human endothelial cells

Fri Sep 01 00:00:00 EDT 1995

Tenidap-modulated proinflammatory cytokine activation of a monocyte cell line.

Journal of immunology (Baltimore, Md. : 1950)

Golding S,Emery P,Young SP

P420B was used in ELISA to investigate the effect of tenidap on the regulation of inflammation response in monocytes

Mon May 15 00:00:00 EDT 1995

Induction of IL-3 and granulocyte-macrophage colony-stimulating factor by substance P in bone marrow cells is partially mediated through the release of IL-1 and IL-6.

Journal of immunology (Baltimore, Md. : 1950)

Rameshwar P,Ganea D,Gascón P

P420B was used in blocking/activating experiment to investigate the production of interleukin 3 and GM-CSF mediated by substance P in bone marrow mononuclear cells

Fri Apr 15 00:00:00 EDT 1994

Synergistic increases in IL-1 synthesis by the human monocytic cell line THP-1 treated with PAF and endotoxin.

Cellular immunology

Barthelson RA,Potter T,Valone FH

P420B was used in immunocytochemistry to investigate the effect of PAF and endotoxin treatment on interleukin 1 expression

Mon Jan 01 00:00:00 EST 1990

Bioinformatics

Protein Aliases: Catabolin; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1β; IL-1 beta; IL1 B; IL1β; ILN; Interleukin; Interleukin 1 beta precursor; interleukin 1, beta; Interleukin-1 beta; Interleukin-1b; Interleukin1 beta; LAF; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; pro-interleukin-1-beta

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Gene Aliases: IL-1; Il-1b; IL-1beta; IL1-BETA; IL1B; IL1F2

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UniProt ID: (Human) P01584, (Mouse) P10749

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Entrez Gene ID: (Human) 3553, (Mouse) 16176

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Function(s)

cytokine activity interleukin-1 receptor binding protein domain specific binding receptor binding interleukin superfamily

Process(es)

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IL-1 beta Polyclonal Antibody

IL-1 beta Antibody (P420B) in ICC/IF

Product Details

P420B

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Immunoprecipitation (IP)

Neutralization (Neu)

Affinity Purification (AP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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