Invitrogen

IL-12 p70 Polyclonal Antibody

View all (23) IL-12 p70 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-115401

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human IL12A(Accession P29459), corresponding to amino acid residues L45-S95.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2900037

Product Specific Information

Antibody detects endogenous levels of total IL12A.

Target Information

IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 20C2; CLMF p35; CLMF p40; cytotoxic lymphocyte maturation factor 1, p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12, subunit p35; IL-12A; IL-12B; IL12, subunit p40; IL12A/B; IL12AB; IL35 subunit; ILN; Interleukin; interleukin 12 p35 subunit; interleukin 12, p35; interleukin 12, p40; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 alpha chain; interleukin-12 beta chain; interleukin-12 p40; Interleukin-12 p70; Interleukin-12 subunit alpha; Interleukin-12 subunit beta; MGC151228; MGC151232; natural killer cell stimulatory factor, 40 kD subunit; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NK cell stimulatory factor chain 2; NKSF1; NKSF2

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Gene Aliases: CLMF; CLMF2; IL-12A; IL-12B; IL-12p35; Il-12p40; Il12; IL12A; IL12B; Il12p40; IMD28; IMD29; Ll12a; NFSK; NKSF; NKSF1; NKSF2; P35; p40

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UniProt ID: (Human) P29459, (Human) P29460, (Rat) Q9R103, (Mouse) P43431, (Mouse) P43432

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Entrez Gene ID: (Human) 3592, (Human) 3593, (Rat) 84405, (Mouse) 16159, (Rat) 64546, (Mouse) 16160

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Function(s)
cytokine activity interleukin-12 receptor binding protein binding growth factor activity interleukin-12 beta subunit binding interleukin-27 binding protein heterodimerization activity cytokine receptor activity interleukin-12 alpha subunit binding identical protein binding protein homodimerization activity interleukin-23 receptor binding cytokine receptor binding transmembrane signal receptor
Process(es)
positive regulation of T cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response cell cycle arrest response to virus response to UV-B cell migration response to lipopolysaccharide negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of natural killer cell activation positive regulation of mononuclear cell proliferation positive regulation of smooth muscle cell apoptotic process positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of Stat4 protein defense response to protozoan positive regulation of T cell differentiation positive regulation of cell adhesion positive regulation of natural killer cell mediated cytotoxicity negative regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation defense response to Gram-positive bacterium positive regulation of NK T cell activation cellular response to lipopolysaccharide extrinsic apoptotic signaling pathway cellular response to virus positive regulation of dendritic cell chemotaxis positive regulation of defense response to virus by host natural killer cell activation involved in immune response positive regulation of T-helper 1 type immune response negative regulation of inflammatory response to antigenic stimulus positive regulation of activation of JAK2 kinase activity cytokine-mediated signaling pathway sensory perception of pain sexual reproduction natural killer cell activation negative regulation of interleukin-10 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation positive regulation of tissue remodeling regulation of cytokine biosynthetic process T-helper 1 type immune response T-helper cell differentiation interferon-gamma biosynthetic process positive regulation of activated T cell proliferation positive regulation of NF-kappaB import into nucleus regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat5 protein positive regulation of memory T cell differentiation negative regulation of growth of symbiont in host positive regulation of interferon-gamma biosynthetic process positive regulation of osteoclast differentiation positive regulation of inflammatory response defense response to Gram-negative bacterium positive regulation of NK T cell proliferation defense response to virus cellular response to interferon-gamma positive regulation of T-helper 17 type immune response positive regulation of T-helper 17 cell lineage commitment cell surface receptor signaling pathway
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