Invitrogen

IL-12 p70 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Neutralization to ensure that the antibody binds to the antigen stated.

View all (23) IL-12 p70 antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-47961

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1 µg/mL
-

Neutralization (Neu)

0.01-0.04 µg/mL
-
Product Specifications

Species Reactivity

Pig

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHO-derived recombinant porcine IL-12 p35/p40 heterodimer Ile23-Asn324 (p40), Arg26-Ser222 (p35)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607646

Product Specific Information

In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human IL-12 is observed, and less than 5% cross-reactivity with recombinant mouse IL-12 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

IL-12 p70, also known as interleukin-12, is a cytokine that plays a critical role in the immune system's response to infections and cancer. It is produced by immune cells, including dendritic cells, macrophages, and B cells, in response to certain pathogens and tumor cells. IL-12 p70 stimulates the production of interferon-gamma and other cytokines, which promote the activation and proliferation of T cells and natural killer cells. IL-12 p70 has been studied as a potential therapeutic target for various diseases and conditions, including infectious diseases, autoimmune disorders, and cancer. It has been shown to enhance immune responses against certain infections and tumors, and to modulate inflammatory responses in autoimmune diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 20C2; CLMF p35; CLMF p40; Cytotoxic lymphocyte maturation factor 35 kDa subunit; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12p70; IL-12 p75; IL-12 subunit p35; IL-12 subunit p40; IL-12A; IL-12B; IL12A/B; IL12AB; ILN; Interleukin; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 p35 subunit; interleukin-12 p40 subunit; Interleukin-12 p70; Interleukin-12 subunit alpha; Interleukin-12 subunit beta; interleukin-23 p40 subunit; MGC151228; MGC151232

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Gene Aliases: IL12A; IL12B

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UniProt ID: (Pig) Q29053, (Pig) Q28938

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Entrez Gene ID: (Pig) 397053, (Pig) 397076

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Function(s)
cytokine activity interleukin-12 receptor binding growth factor activity interleukin-12 beta subunit binding interleukin-27 binding protein heterodimerization activity identical protein binding interleukin-23 receptor binding transmembrane signal receptor
Process(es)
positive regulation of T cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target cell cycle arrest cell proliferation response to UV-B cell migration negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of natural killer cell activation positive regulation of smooth muscle cell apoptotic process T-helper 1 cell activation T-helper 1 cell cytokine production positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein defense response to protozoan positive regulation of T cell differentiation negative regulation of smooth muscle cell proliferation negative regulation of protein secretion defense response to Gram-positive bacterium positive regulation of NK T cell activation cellular response to lipopolysaccharide extrinsic apoptotic signaling pathway cellular response to virus negative regulation of vascular endothelial growth factor signaling pathway negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of dendritic cell chemotaxis positive regulation of defense response to virus by host positive regulation of T-helper 1 type immune response negative regulation of inflammatory response to antigenic stimulus positive regulation of activation of Janus kinase activity natural killer cell activation negative regulation of interleukin-10 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell proliferation T-helper cell differentiation positive regulation of activated T cell proliferation positive regulation of osteoclast differentiation defense response to Gram-negative bacterium positive regulation of NK T cell proliferation defense response to virus cellular response to interferon-gamma
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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