Product References
Indole-3-pyruvic acid alleviates rheumatoid arthritis via the aryl hydrocarbon receptor pathway.
Annals of translational medicine
Huang T,Cheng L,Jiang Y,Zhang L,Qian L
12-7177-81 was used in Flow Cytometry to reveal the effect and mechanism of indole-3-pyruvic acid (IPA) in rheumatoid arthritis (RA).
Wed Mar 15 00:00:00 EDT 2023
An optical system for noninvasive microscopy of psoriatic mice in vivo.
Journal of biophotonics
Lu Y,Zhu Y,Zhao X,Pan M,He H
12-7177-81 was used in In vivo experiments to suggest IL-23 recruits CD4+ cells to release IL-17 in blood that further leaks out in the psoriatic skin area.
Sat Apr 01 00:00:00 EDT 2023
Identification of astrocyte regulators by nucleic acid cytometry.
Nature
Clark IC,Wheeler MA,Lee HG,Li Z,Sanmarco LM,Thaploo S,Polonio CM,Shin SW,Scalisi G,Henry AR,Rone JM,Giovannoni F,Charabati M,Akl CF,Aleman DM,Zandee SEJ,Prat A,Douek DC,Boritz EA,Quintana FJ,Abate AR
12-7177-81 was used in Flow cytometry/Cell sorting to develop focused interrogation of cells by nucleic acid detection and sequencing (FIND-seq), a high-throughput microfluidic cytometry method that combines encapsulation of cells in droplets, PCR-based detection of target nucleic acids and droplet sorting to enable in-depth transcriptomic analyses of cells of interest at single-cell resolution.
Wed Feb 01 00:00:00 EST 2023
Fermented cordyceps powder alleviates silica-induced pulmonary inflammation and fibrosis in rats by regulating the Th immune response.
Chinese medicine
Pu S,Yang Z,Zhang X,Li M,Han N,Yang X,He J,Yu G,Meng X,Jia Q,Shao H
12-7177-81 was used in Flow Cytometry to explore the related mechanism.
Thu Oct 12 00:00:00 EDT 2023
CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.
Neurology(R) neuroimmunology & neuroinflammation
Gupta S,Simic M,Sagan SA,Shepherd C,Duecker J,Sobel RA,Dandekar R,Wu GF,Wu W,Pak JE,Hauser SL,Lim W,Wilson MR,Zamvil SS
12-7177-81 was used in Flow cytometry/Cell sorting to observe that anti-CD19 CAR-T cells ameliorated experimental autoimmune encephalomyelitis and thoroughly deplete B cells in peripheral tissues and in the CNS.
Wed Mar 01 00:00:00 EST 2023
Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases.
Arthritis research & therapy
Chen YH,Liu RH,Cui YZ,Hettinghouse A,Fu WY,Zhang L,Zhang C,Liu CJ
12-7177-81 was used in Flow Cytometry to investigate the therapeutic effect of penfluridol on TNFα-stimulated inflammatory autoimmune diseases, particularly inflammatory arthritis.
Wed Jan 19 00:00:00 EST 2022
miR-126 ameliorates multiple organ dysfunction in septic rats by regulating the differentiation of Th17/Treg.
Molecular biology reports
Zou Q,Liu C,Hu N,Wang W,Wang H
12-7177-81 was used in Flow Cytometry to show that miR-126 can regulate the differentiation of Th17/Treg, change the infiltration of inflammatory factors in peripheral blood, lung, liver and kidney of septic rats, alleviate multiple organ dysfunction syndrome, and improve the organ function and prognosis of septic rats.
Fri Apr 01 00:00:00 EDT 2022
Rhubarb Alleviates Acute Lung Injury by Modulating Gut Microbiota Dysbiosis in Mice.
Current microbiology
Tang T,Wang F,Liu J,Ye W,Zhao T,Li Z
12-7177-81 was used in Flow Cytometry to show that rhubarb promoted Alistipes, Clostridium, and Lactobacillus proliferation, increased the HDAC6 concentration, restored the Th17/Treg cell balance, and protected against acute lung injury.
Sat Feb 26 00:00:00 EST 2022
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.
Cell & bioscience
Cui X,Ye Z,Wang D,Yang Y,Jiao C,Ma J,Tang N,Zhang H
12-7177-81 was used in Flow Cytometry to investigate whether the activation of AhR can induce tolerogenic DCs (tolDCs) and the differentiation of regulatory T (Treg) cells, as well as ameliorate experimental colitis.
Sat Apr 23 00:00:00 EDT 2022
Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis.
Cell reports
Viladomiu M,Khounlotham M,Dogan B,Lima SF,Elsaadi A,Cardakli E,Castellanos JG,Ng C,Herzog J,Schoenborn AA,Ellermann M,Liu B,Zhang S,Gulati AS,Sartor RB,Simpson KW,Lipkin SM,Longman RS
12-7177-81 was used in Flow cytometry/Cell sorting to reveal a specific and reciprocal interaction of the expansion of the CD pathobiont AIEC with ER-stress-associated ileocolitis and highlight a distinct cellular mechanism for IL-23-dependent ileocolitis.
Tue Nov 15 00:00:00 EST 2022
Methotrexate-loaded nanoparticles ameliorate experimental model of autoimmune arthritis by regulating the balance of interleukin-17-producing T cells and regulatory T cells.
Journal of translational medicine
Park JS,Lee D,Yang S,Jeong HY,Na HS,Cho KH,Choi J,Koo H,Cho ML,Park SH
12-7177-81 was used in Immunohistochemistry to study the efficacy of methotrexate-loaded nanoparticles against experimental model of rheumatoid arthritis.
Fri Feb 11 00:00:00 EST 2022
AntiGan: An Epinutraceutical Bioproduct with Antitumor Properties in Cultured Cell Lines.
Life (Basel, Switzerland)
Martínez-Iglesias O,Carrera I,Naidoo V,Cacabelos R
12-7177-81 was used in Immunocytochemistry-immunoflourescence to conclude that AntiGan is a novel antitumoral bioproduct with epigenetic properties (epinutraceutical) for treating liver and colorectal cancer.
Mon Jan 10 00:00:00 EST 2022
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Immunity
Sugiura A,Andrejeva G,Voss K,Heintzman DR,Xu X,Madden MZ,Ye X,Beier KL,Chowdhury NU,Wolf MM,Young AC,Greenwood DL,Sewell AE,Shahi SK,Freedman SN,Cameron AM,Foerch P,Bourne T,Garcia-Canaveras JC,Karijolich J,Newcomb DC,Mangalam AK,Rabinowitz JD,Rathmell JC
12-7177-81 was used in Flow cytometry/Cell sorting to show that MTHFD2 is a metabolic checkpoint to integrate purine metabolism with pathogenic effector cell signaling and is a potential therapeutic target within 1C metabolism pathways.
Tue Jan 11 00:00:00 EST 2022
Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2.
EBioMedicine
Hu X,Zou Y,Copland DA,Schewitz-Bowers LP,Li Y,Lait PJP,Stimpson M,Zhang Z,Guo S,Liang J,Chen T,Li JJ,Yuan S,Li S,Zhou P,Liu Y,Dick AD,Wen X,Lee RWJ,Wei L
12-7177-81 was used in Flow cytometry/Cell sorting to provide evidence of the strong potential for IOX1 as a viable therapy for inflammatory diseases, in particular of the eye.
Thu Dec 01 00:00:00 EST 2022
Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2.
EBioMedicine
Hu X,Zou Y,Copland DA,Schewitz-Bowers LP,Li Y,Lait PJP,Stimpson M,Zhang Z,Guo S,Liang J,Chen T,Li JJ,Yuan S,Li S,Zhou P,Liu Y,Dick AD,Wen X,Lee RWJ,Wei L
12-7177-81 was used in Flow cytometry/Cell sorting to provide evidence of the strong potential for IOX1 as a viable therapy for inflammatory diseases, in particular of the eye.
Thu Dec 01 00:00:00 EST 2022
Platelet Extracellular Vesicles Are Taken up by Canine T Lymphocytes but Do Not Play a Role in Their Proliferation, Differentiation and Cytokine Production In Vitro.
International journal of molecular sciences
Żmigrodzka M,Witkowska-Piłaszewicz O,Pingwara R,Winnicka A
12-7177-81 was used in Flow cytometry/Cell sorting to evaluate the influence of PEVs on lymphocyte proliferation, phenotype and cytokine production in vitro.
Sat May 14 00:00:00 EDT 2022
MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis.
Journal of inflammation research
Liu Y,Zhao N,Xu Q,Deng F,Wang P,Dong L,Lu X,Xia L,Wang M,Chen Z,Zhou J,Zuo D
12-7177-81 was used in Flow cytometry/Cell sorting to suggest that MBL limited the Th17 immunity via controlling the AhR/STAT3 pathway, thus providing new insight into silicosis and other inflammatory diseases in patients with MBL deficiency.
Fri Aug 05 00:00:00 EDT 2022
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
Immunity
Lin X,Gaudino SJ,Jang KK,Bahadur T,Singh A,Banerjee A,Beaupre M,Chu T,Wong HT,Kim CK,Kempen C,Axelrad J,Huang H,Khalid S,Shah V,Eskiocak O,Parks OB,Berisha A,McAleer JP,Good M,Hoshino M,Blumberg R,Bialkowska AB,Gaffen SL,Kolls JK,Yang VW,Beyaz S,Cadwell K,Kumar P
12-7177-81 was used in Flow cytometry/Cell sorting to suggest that the cross talk between immune cells and stem cells regulates secretory cell lineage commitment and the integrity of the mucosa.
Tue Feb 08 00:00:00 EST 2022
Early and Polyantigenic CD4 T Cell Responses Correlate with Mild Disease in Acute COVID-19 Donors.
International journal of molecular sciences
Tarke A,Potesta M,Varchetta S,Fenoglio D,Iannetta M,Sarmati L,Mele D,Dentone C,Bassetti M,Montesano C,Mondelli MU,Filaci G,Grifoni A,Sette A
12-7177-81 was used in Flow cytometry/Cell sorting to highlight that both the magnitude and breadth of early SARS-CoV-2-specific CD4+ T cell responses correlated with milder disease outcomes in acute COVID-19 patients.
Tue Jun 28 00:00:00 EDT 2022
Liangxue Tongyu Prescription Alleviates Brain Damage in Acute Intracerebral Hemorrhage Rats by Regulating Intestinal Mucosal Barrier Function.
Evidence-based complementary and alternative medicine : eCAM
Zhou Y,Zhang Z,Sun Y,Zhou D,Zhao Y,Li J,Guo W
12-7177-81 was used in Flow cytometry/Cell sorting to show that LTP can effectively reduce the degree of brain damage in AICH rats, and the mechanism may be that it can play a neuroprotective role by regulating the function of the intestinal mucosal barrier.
Tue Jan 03 00:00:00 EST 2023
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes.
Nature
Sanmarco LM,Wheeler MA,Gutiérrez-Vázquez C,Polonio CM,Linnerbauer M,Pinho-Ribeiro FA,Li Z,Giovannoni F,Batterman KV,Scalisi G,Zandee SEJ,Heck ES,Alsuwailm M,Rosene DL,Becher B,Chiu IM,Prat A,Quintana FJ
12-7177-81 was used in Flow Cytometry to show that LAMP1+TRAIL+ astrocytes limit CNS inflammation by inducing T cell apoptosis, and that this astrocyte subset is maintained by meningeal IFNγ+ NK cells that are licensed by the microbiome.
Mon Feb 01 00:00:00 EST 2021
Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation.
Cell host & microbe
Viladomiu M,Metz ML,Lima SF,Jin WB,Chou L,Guo CJ,Diehl GE,Simpson KW,Scherl EJ,Longman RS
12-7177-81 was used in Flow cytometry/Cell sorting to identify MNPs as metabolic sensors linking AIEC metabolism with intestinal inflammation and identify microbial metabolism as a potential therapeutic target in Crohn's disease treatment.
Wed Apr 14 00:00:00 EDT 2021
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Ma C,Li S,Hu Y,Ma Y,Wu Y,Wu C,Liu X,Wang B,Hu G,Zhou J,Yang S
12-7177 was used in Flow cytometry/Cell sorting to identify a new role for AIM2 in controlling the onset of EAE.
Mon May 03 00:00:00 EDT 2021
Dynamic changes in the systemic immune responses of spinal cord injury model mice.
Neural regeneration research
Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B
12-7177 was used in Flow cytometry/Cell sorting to decipher the dynamics of systemic immune responses, initiated by spinal cord injury.
Mon Feb 01 00:00:00 EST 2021
The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice.
Mediators of inflammation
Chen J,Yang F,Shi S,Liu X,Qin F,Wei X,Huang Y,Liang W,Miao L
12-7177-81 was used in Flow Cytometry to demonstrate a key role of the NLRP3 inflammasome and its close relationship with Th17 in the pathological progression of coxsackievirus B3-induced viral myocarditis.
Wed Dec 22 00:00:00 EST 2021
Gallic Acid Ameliorates Atopic Dermatitis-Like Skin Inflammation Through Immune Regulation in a Mouse Model.
Clinical, cosmetic and investigational dermatology
Hu G,Zhou X
12-7177-81 was used in Flow Cytometry to show that GA could ameliorate AD-like skin inflammation possibly through Th17 mediated immune regulation in a DNCB-induced mouse model.
Thu Apr 28 00:00:00 EDT 2022
Toxicity of Melastoma dodecandrum Lour. and its effects on lipopolysaccharide-induced inflammation and oxidative stress.
Experimental and therapeutic medicine
Huang G,Ge Y,Gui Z,Zhu M,Liu J,Wang H
12-7177-81 was used in Flow Cytometry to demonstrate the non-toxic nature of MDL and revealed that it alleviated LPS-induced inflammation and oxidative stress by regulating differentiation and ROS production in CD4+ T cells.
Sun Aug 01 00:00:00 EDT 2021
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
12-7177-81 was used in Flow cytometry/Cell sorting to conclude that induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC.
Tue Sep 21 00:00:00 EDT 2021
T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance.
Bioactive materials
Yang X,Zhou F,Yuan P,Dou G,Liu X,Liu S,Wang X,Jin R,Dong Y,Zhou J,Lv Y,Deng Z,Liu S,Chen X,Han Y,Jin Y
12-7177 was used in Flow cytometry/Cell sorting to show that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in vivo.
Fri Oct 01 00:00:00 EDT 2021
The gut microbiota is a transmissible determinant of skeletal maturation.
eLife
Tyagi AM,Darby TM,Hsu E,Yu M,Pal S,Dar H,Li JY,Adams J,Jones RM,Pacifici R
12-7177-81 was used in Flow Cytometry to show that the gut microbiome is a communicable regulator of bone structure and turnover in mice.
Tue Jan 12 00:00:00 EST 2021
MAFG-driven astrocytes promote CNS inflammation.
Nature
Wheeler MA,Clark IC,Tjon EC,Li Z,Zandee SEJ,Couturier CP,Watson BR,Scalisi G,Alkwai S,Rothhammer V,Rotem A,Heyman JA,Thaploo S,Sanmarco LM,Ragoussis J,Weitz DA,Petrecca K,Moffitt JR,Becher B,Antel JP,Prat A,Quintana FJ
12-7177-81 was used in Flow Cytometry to identify candidate therapeutic targets in multiple sclerosis.
Sat Feb 01 00:00:00 EST 2020
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
12-7177 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice.
The American journal of psychiatry
Medina-Rodriguez EM,Madorma D,O'Connor G,Mason BL,Han D,Deo SK,Oppenheimer M,Nemeroff CB,Trivedi MH,Daunert S,Beurel E
12-7177-81 was used in Flow Cytometry to reveal a novel mechanism by which bacteria alter mood.
Thu Oct 01 00:00:00 EDT 2020
Critical role of OX40 in drug-induced acute liver injury.
British journal of pharmacology
Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D
12-7177-81 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.
Wed Jul 01 00:00:00 EDT 2020
IQGAP1 restrains T-cell cosignaling mediated by OX40.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Okuyama Y,Nagashima H,Ushio-Fukai M,Croft M,Ishii N,So T
12-7177-81 was used in ELISA to define an important component of the OX40 cosignaling that restricts inflammation driven by antigen-activated T cells.
Wed Jan 01 00:00:00 EST 2020
Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis.
Mediators of inflammation
Li HB,Zhou Y,Zhao AH,Guo LL
12-7177 was used in Flow cytometry/Cell sorting to report that sepsis induced MVZ to inhibit CAP which underlies the inflammation storm.
Mon Aug 02 00:00:00 EDT 2021
TIRC7 inhibits Th1 cells by upregulating the expression of CTLA‑4 and STAT3 in mice with acute graft‑versus‑host disease.
Oncology reports
Zhu F,Qiu T,Zhu S,Zhao K,Chen C,Qiao J,Pan B,Yan Z,Chen W,Liu Q,Wu Q,Cao J,Sang W,Zeng L,Sun H,Li Z,Xu K
12-7177 was used in Flow cytometry/Cell sorting to deepen the understanding of the pathogenesis of acute graft-versus-host disease (GVHD) and provide novel approaches for controlling acute GVHD.
Wed Jul 01 00:00:00 EDT 2020
Orthodontic treatment induces Th17/Treg cells to regulate tooth movement in rats with periodontitis.
Iranian journal of basic medical sciences
Ge N,Peng J,Yu L,Huang S,Xu L,Su Y,Chen L
12-7177 was used in Flow cytometry/Cell sorting to investigate the regulation of Th17 and Treg cells in orthodontic tooth movement during periodontal inflammation.
Thu Oct 01 00:00:00 EDT 2020
Host immunology and rational immunotherapy for carbapenem-resistant Klebsiella pneumoniae infection.
JCI insight
Iwanaga N,Sandquist I,Wanek A,McCombs J,Song K,Kolls JK
12-7177 was used in Flow cytometry/Cell sorting to support the development of host-directed immunotherapy as an adjunct treatment to new antibiotics.
Thu Apr 23 00:00:00 EDT 2020
UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation.
PloS one
O'Connor EB,Muñoz-Wolf N,Leon G,Lavelle EC,Mills KHG,Walsh PT,Porter RK
12-7177 was used in Flow cytometry/Cell sorting to demonstrate that Ucp3 is expressed in peripheral naive CD4+ T cells at the mRNA level before being markedly downregulated following activation.
Thu Jan 07 00:00:00 EST 2021
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study.
Nature communications
Hu F,Jiang X,Guo C,Li Y,Chen S,Zhang W,Du Y,Wang P,Zheng X,Fang X,Li X,Song J,Xie Y,Huang F,Xue J,Bai M,Jia Y,Liu X,Ren L,Zhang X,Guo J,Pan H,Su Y,Yi H,Ye H,Zuo D,Li J,Wu H,Wang Y,Li R,Liu L,Wang XY,Li Z
12-7177 was used in Flow cytometry/Cell sorting to assess the discriminative power of serum scavenger receptor-A (sSR-A) for rheumatoid arthritis diagnosis.
Mon Apr 20 00:00:00 EDT 2020
Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.
Cell
Chao CC,Gutiérrez-Vázquez C,Rothhammer V,Mayo L,Wheeler MA,Tjon EC,Zandee SEJ,Blain M,de Lima KA,Takenaka MC,Avila-Pacheco J,Hewson P,Liu L,Sanmarco LM,Borucki DM,Lipof GZ,Trauger SA,Clish CB,Antel JP,Prat A,Quintana FJ
12-7177-81 was used in Flow Cytometry to define a novel immunometabolic mechanism that drives pro-inflammatory astrocyte activities.
Thu Dec 12 00:00:00 EST 2019
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
12-7177-81 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.
Tue Jan 15 00:00:00 EST 2019
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Li S,Wu Y,Yang D,Wu C,Ma C,Liu X,Moynagh PN,Wang B,Hu G,Yang S
12-7177-81 was used in Flow Cytometry to study how GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS, leading to the suppression of neuroinflammation and demyelination.
Mon Nov 04 00:00:00 EST 2019
Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.
The American journal of Chinese medicine
Li Q,Shan Q,Sang X,Zhu R,Chen X,Cao G
12-7177 was used in Flow cytometry/Cell sorting to investigate the effects of total glycoside of peony on experimental colitis mice.
Fri Mar 15 00:00:00 EDT 2019
Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.
Mediators of inflammation
Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M
12-7177 was used in Flow cytometry/Cell sorting to explore the therapeutic effects and mechanisms of interleukin 10 gene-modified bone marrow-derived dendritic cells on liver fibrosis.
Tue Jun 11 00:00:00 EDT 2019
Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection.
Parasite (Paris, France)
Song Y,Xu J,Wang X,Yang Y,Bai X,Pang J,Wang X,Yu M,Liu M,Liu X,Sun S
12-7177 was used in Flow cytometry/Cell sorting to examine immune cells and cytokine profiles of Trichinella spiralis infected mice by Meso Scale Discovery (MSD) and flow cytometry.
Fri May 08 00:00:00 EDT 2020
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
12-7177-81 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota.
Cell reports
Zhang H,Carnevale G,Polese B,Simard M,Thurairajah B,Khan N,Gentile ME,Fontes G,Vinh DC,Pouliot R,King IL
12-7177-81 was used in Flow Cytometry to provide insight into the regulation of the skin IL-23/IL-17 immune axis and how homeostasis is maintained at this important barrier site.
Tue Oct 08 00:00:00 EDT 2019
Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses.
Journal of neuroinflammation
Quan MY,Song XJ,Liu HJ,Deng XH,Hou HQ,Chen LP,Ma TZ,Han X,He XX,Jia Z,Guo L
12-7177-81 was used in Flow Cytometry to study the effect of ALX on the maturation of dendritic cells and the responses of effector and regulatory T cells.
Fri Mar 01 00:00:00 EST 2019
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Nature communications
Scheer S,Ackloo S,Medina TS,Schapira M,Li F,Ward JA,Lewis AM,Northrop JP,Richardson PL,Kaniskan HÜ,Shen Y,Liu J,Smil D,McLeod D,Zepeda-Velazquez CA,Luo M,Jin J,Barsyte-Lovejoy D,Huber KVM,De Carvalho DD,Vedadi M,Zaph C,Brown PJ,Arrowsmith CH
12-7177 was used in Flow cytometry/Cell sorting to present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine protein methyltransferases in cellular studies.
Thu Jan 03 00:00:00 EST 2019
Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells.
Cellular and molecular gastroenterology and hepatology
Kiyohara H,Sujino T,Teratani T,Miyamoto K,Arai MM,Nomura E,Harada Y,Aoki R,Koda Y,Mikami Y,Mizuno S,Naganuma M,Hisamatsu T,Kanai T
12-7177 was used in Flow cytometry/Cell sorting to show that skin inflammation may contribute to pathogenic conditions in the gut via immunologic and microbiological changes.
Mon Apr 29 00:00:00 EDT 2019
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Immunity
Emgård J,Kammoun H,García-Cassani B,Chesné J,Parigi SM,Jacob JM,Cheng HW,Evren E,Das S,Czarnewski P,Sleiers N,Melo-Gonzalez F,Kvedaraite E,Svensson M,Scandella E,Hepworth MR,Huber S,Ludewig B,Peduto L,Villablanca EJ,Veiga-Fernandes H,Pereira JP,Flavell RA,Willinger T
12-7177 was used in Flow cytometry/Cell sorting to show that GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls ILC3 activity and intestinal homeostasis.
Tue Jan 16 00:00:00 EST 2018
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling.
Immunity
Spidale NA,Sylvia K,Narayan K,Miu B,Frascoli M,Melichar HJ,Zhihao W,Kisielow J,Palin A,Serwold T,Love P,Kobayashi M,Yoshimoto M,Jain N,Kang J
12-7177-81 was used in Flow Cytometry to generate reporter mice for the Tγδ17 lineage-defining transcription factor SOX13 and identify fetal-origin, intrathymic Sox13+ progenitors.
Tue Nov 20 00:00:00 EST 2018
Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice.
PLoS pathogens
Skalski JH,Limon JJ,Sharma P,Gargus MD,Nguyen C,Tang J,Coelho AL,Hogaboam CM,Crother TR,Underhill DM
12-7177 was used in Flow cytometry/Cell sorting to investigate the effects of the population expansion of commensal fungus Wallemia mellicola without overgrowth of the total fungal community.
Sat Sep 01 00:00:00 EDT 2018
Effect of immune tolerance induced by immature dendritic cells and CTLA4-Ig on systemic lupus erythematosus: An in vivo study.
Experimental and therapeutic medicine
Huang C,Zhang L,Ling F,Wen S,Luo Y,Liu H,Liu J,Zheng W,Liang M,Sun J,Lin YK
12-7177-81 was used in Flow Cytometry to suggest that combined treatment with IL-10-DCs and CTLA4-Ig may be a promising novel therapeutic strategy for the treatment of SLE.
Thu Mar 01 00:00:00 EST 2018
Topical Application of TGF-β-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation.
International journal of molecular sciences
Soriano-Romaní L,Contreras-Ruiz L,López-García A,Diebold Y,Masli S
12-7177 was used in Flow cytometry/Cell sorting to identify the KRFK peptide as a novel therapeutic option to prevent the development of chronic inflammatory manifestations of the ocular surface.
Thu Dec 20 00:00:00 EST 2018
Activated Α7nachr Improves Postoperative Cognitive Dysfunction and Intestinal Injury Induced by Cardiopulmonary Bypass in Rats: Inhibition of the Proinflammatory Response Through the Th17 Immune Response.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Chen K,Sun Y,Dong W,Zhang T,Zhou N,Yu W,Diao Y,Guo S,Tian Y
12-7177-81 was used in Flow cytometry/Cell sorting to investigate the effects of activated α7 nicotinic acetylcholine receptor (α7nAChR) on postoperative cognitive dysfunction (POCD) and intestinal injury induced by cardiopulmonary bypass (CPB) and its relationship with the Th17 response in order to provide a theoretical basis for organ protection and targeted drug therapy during the perioperative period.
Thu Jul 05 00:00:00 EDT 2018
Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice.
International journal of molecular sciences
Wang C,Zaheer M,Bian F,Quach D,Swennes AG,Britton RA,Pflugfelder SC,de Paiva CS
12-7177 was used in Flow cytometry/Cell sorting to study the role of commensal bacteria in the maintenance of immune homeostasis at the ocular surface and lacrimal gland.
Tue Feb 13 00:00:00 EST 2018
Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model.
Scientific reports
Lee SW,Park HJ,Van Kaer L,Hong S,Hong S
12-7177 was used in Flow cytometry/Cell sorting to investigate the impact of GO on inflammatory responses mediated by α-galactosylceramide, an invariant natural killer T cell agonist.
Wed Jul 04 00:00:00 EDT 2018
CD4 T cell autophagy is integral to memory maintenance.
Scientific reports
Murera D,Arbogast F,Arnold J,Bouis D,Muller S,Gros F
12-7177 was used in Flow cytometry/Cell sorting to propose that memory CD4+ T-cells rely on autophagy for their survival to regulate toxicity of mitochondrial activity and lipid overload.
Fri Apr 13 00:00:00 EDT 2018
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
12-7177 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.
The Journal of allergy and clinical immunology
Joetham A,Schedel M,O'Connor BP,Kim S,Takeda K,Abbott J,Gelfand EW
12-7177 was used in Flow cytometry/Cell sorting to study the differences between the pathways leading to enhancement of lung allergic responses by both transferred naturally occurring regulatory T and inducible regulatory T cells.
Sat Apr 01 00:00:00 EDT 2017
Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Schampel A,Volovitch O,Koeniger T,Scholz CJ,Jörg S,Linker RA,Wischmeyer E,Wunsch M,Hell JW,Ergün S,Kuerten S
12-7177 was used in Flow cytometry/Cell sorting to show that nimodipine application generates a favourable environment for regenerative processes and could be a treatment option for multiple sclerosis.
Tue Apr 18 00:00:00 EDT 2017
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.
Gut microbes
Jacobs JP,Lin L,Goudarzi M,Ruegger P,McGovern DP,Fornace AJ,Borneman J,Xia L,Braun J
12-7177 was used in Flow cytometry/Cell sorting to identify polymorphisms near C1galt1 and its molecular chaperone, Cosmc, were associated with altered composition of the colonic mucosal microbiota.
Mon Jan 02 00:00:00 EST 2017
mTORC2 regulates multiple aspects of NKT-cell development and function.
European journal of immunology
Sklarz T,Guan P,Gohil M,Cotton RM,Ge MQ,Haczku A,Das R,Jordan MS
12-7177 was used in Flow cytometry/Cell sorting to define the molecular pathway and role of Rictor in regulating invariant NKT-cell fate.
Wed Mar 01 00:00:00 EST 2017
Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma.
Journal of immunology (Baltimore, Md. : 1950)
Movassagh H,Shan L,Mohammed A,Halayko AJ,Gounni AS
12-7177 was used in Flow cytometry/Cell sorting to identify Semaphorin 3E as a novel regulatory molecule in allergic asthma that acts upstream of proallergic events.
Wed Mar 01 00:00:00 EST 2017
Loss of Tff1 Promotes Pro-Inflammatory Phenotype with Increase in the Levels of RORγt+ T Lymphocytes and Il-17 in Mouse Gastric Neoplasia.
Journal of Cancer
Soutto M,Saleh M,Arredouani MS,Piazuelo B,Belkhiri A,El-Rifai W
12-7177 was used in Flow cytometry/Cell sorting to utilize the Tff1-KO mouse model to assess the impact of TFF1 loss on immune cells infiltration in the stomach.
Wed May 26 00:00:00 EDT 2021
ID3 may protect mice from anti‑GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells.
Molecular medicine reports
Zhou H,Wang L,Xu Q,Liu Q,Liu H,Qiu W,Hu T,Lv Y,Zhang Q
12-7177 was used in Flow cytometry/Cell sorting to report of a protective role of ID3 from anti-GBM glomerulonephritis.
Fri Dec 01 00:00:00 EST 2017
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.
Scientific reports
Minter MR,Hinterleitner R,Meisel M,Zhang C,Leone V,Zhang X,Oyler-Castrillo P,Zhang X,Musch MW,Shen X,Jabri B,Chang EB,Tanzi RE,Sisodia SS
12-7177 was used in Flow cytometry/Cell sorting to investigate how ABX-induced microbial diversity perturbations during post-natal stages of development coincide with altered host immunity mechanisms and amyloidosis in a murine model of AD.
Tue Sep 05 00:00:00 EDT 2017
Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Nature communications
Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N
12-7177 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.
Tue Mar 14 00:00:00 EDT 2017
Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.
eLife
Araujo L,Khim P,Mkhikian H,Mortales CL,Demetriou M
12-7177 was used in Flow cytometry/Cell sorting to report that aerobic glycolysis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse T cell blasts by starving the hexosamine pathway of glucose and glutamine.
Fri Jan 06 00:00:00 EST 2017
Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health.
Scientific reports
Novince CM,Whittow CR,Aartun JD,Hathaway JD,Poulides N,Chavez MB,Steinkamp HM,Kirkwood KA,Huang E,Westwater C,Kirkwood KL
12-7177 was used in Flow cytometry/Cell sorting to study the infulence of commensal gut microbiota in the skeletal homeosasis of adult mice.
Tue Jul 18 00:00:00 EDT 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
12-7177 was used in Flow cytometry/Cell sorting to investigate the effect Paeoniflorin has on Th cells and dendritic cells in a mouse MS model.
Mon Feb 06 00:00:00 EST 2017
Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb.) water extract prevents DSS-induced colitis in mice by up-regulating type II T helper immune responses.
BMC complementary and alternative medicine
Park HJ,Lee SW,Kwon DJ,Heo SI,Park SH,Kim SY,Hong S
12-7177 was used in Flow cytometry/Cell sorting to show that taheebo water extract (TWE) is an excellent natural product with therapeutic effects to help improve inflammatory disorders such as colitis.
Wed Sep 06 00:00:00 EDT 2017
Immune activation caused by vascular oxidation promotes fibrosis and hypertension.
The Journal of clinical investigation
Wu J,Saleh MA,Kirabo A,Itani HA,Montaniel KR,Xiao L,Chen W,Mernaugh RL,Cai H,Bernstein KE,Goronzy JJ,Weyand CM,Curci JA,Barbaro NR,Moreno H,Davies SS,Roberts LJ,Madhur MS,Harrison DG
12-7177 was used in Immunohistochemistry to explore the physiological consequences of excessive production of reactive oxygen species in vascular tissues.
Fri Jan 01 00:00:00 EST 2016
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Clinical and experimental immunology
Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X
12-7177 was used in Flow cytometry/Cell sorting to investigate the impact of nasal heat shock protein 60 on atherosclerosis and the mechanisms underlying the anti-atherosclerosis responses.
Tue Mar 01 00:00:00 EST 2016
Activation of the Renin-Angiotensin System Promotes Colitis Development.
Scientific reports
Shi Y,Liu T,He L,Dougherty U,Chen L,Adhikari S,Alpert L,Zhou G,Liu W,Wang J,Deb DK,Hart J,Liu SQ,Kwon J,Pekow J,Rubin DT,Zhao Q,Bissonnette M,Li YC
12-7177 was used in Flow cytometry/Cell sorting to demonstrate that the renin-angiotensin II cascade promotes colitis by stimulating intestinal epithelial cell apoptosis and mucosal TH17 responses in a blood pressure-independent manner.
Wed Jun 08 00:00:00 EDT 2016
Lymphocyte Isolation, Th17 Cell Differentiation, Activation, and Staining.
Bio-protocol
Kumar P,Kolls JK
12-7177 was used in Flow cytometry/Cell sorting to describe the tools, reagents and procdedure for a Th17 cell differentiation method.
Mon Dec 05 00:00:00 EST 2016
Human embryonic mesenchymal stem cells alleviate pathologic changes of MRL/Lpr mice by regulating Th7 cell differentiation.
Renal failure
Yuan L,Xiao ZT,Huang XZ,Wu MJ,Shi H,Liu AF
12-7177-81 was used in Flow cytometry/Cell sorting to suggest that hMSC therapy could alleviate systemic and local renal lesions in MRL/Lpr mice, probably by secreting immune regulating factors and regulating Th17 cell differentiation in MRL/Lpr mice.
Sat Oct 01 00:00:00 EDT 2016
Ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade.
Scientific reports
Che L,Jin Y,Zhang C,Lai T,Zhou H,Xia L,Tian B,Zhao Y,Liu J,Wu Y,Wu Y,Du J,Li W,Ying S,Chen Z,Shen H
12-7177 was used in Flow cytometry/Cell sorting to demonstrate that ozone-induced IL-17A and neutrophilic airway inflammation is orchestrated by the caspase-1-IL-1 cascade.
Thu Jan 07 00:00:00 EST 2016
IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease.
Nature communications
Tosiek MJ,Fiette L,El Daker S,Eberl G,Freitas AA
12-7177 was used in Flow cytometry/Cell sorting to demonstrate that impaired delivery of IL-15 to CD4+ T cells in the colon down-modulates Foxp3 expression and enhances RORγt expression.
Fri Mar 11 00:00:00 EST 2016
Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis.
JCI insight
Collins SL,Chan-Li Y,Oh M,Vigeland CL,Limjunyawong N,Mitzner W,Powell JD,Horton MR
12-7177 was used in Flow cytometry/Cell sorting to demonstrate that lung-directed immunotherapy induces an antifibrotic T cell response capable of arresting and reversing lung fibrosis.
Thu Apr 07 00:00:00 EDT 2016
Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation.
Cell reports
Khare A,Raundhal M,Chakraborty K,Das S,Corey C,Kamga CK,Quesnelle K,St Croix C,Watkins SC,Morse C,Oriss TB,Huff R,Hannum R,Ray P,Shiva S,Ray A
12-7177 was used in Flow cytometry/Cell sorting to study how communication between PPARγ and the mitochondria maintains immune quiescence in the airways.
Tue May 24 00:00:00 EDT 2016
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.
Nature communications
Meininger I,Griesbach RA,Hu D,Gehring T,Seeholzer T,Bertossi A,Kranich J,Oeckinghaus A,Eitelhuber AC,Greczmiel U,Gewies A,Schmidt-Supprian M,Ruland J,Brocker T,Heissmeyer V,Heyd F,Krappmann D
12-7177 was used in Flow cytometry/Cell sorting to study how TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
Tue Apr 12 00:00:00 EDT 2016
Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.
Scientific reports
Kwon HK,Kim GC,Hwang JS,Kim Y,Chae CS,Nam JH,Jun CD,Rudra D,Surh CD,Im SH
12-7177 was used in Flow cytometry/Cell sorting to suggest that NFAT1 switches on activation induced cell death in CD4+/CD8+ T cells to maintain peripheral tolerance and prevent inflammatory skin disease.
Mon Jan 18 00:00:00 EST 2016
Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Garimella MG,Kour S,Piprode V,Mittal M,Kumar A,Rani L,Pote ST,Mishra GC,Chattopadhyay N,Wani MR
12-7177 was used in Flow cytometry/Cell sorting to investigate role of mesechymal stem cells in prevention of bone destruction in rheumatoid arthritis.
Tue Dec 01 00:00:00 EST 2015
ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes.
Endocrinology
Solt LA,Banerjee S,Campbell S,Kamenecka TM,Burris TP
12-7177 was used in Flow cytometry/Cell sorting to investigate the roles and therapeutic potential for targeting the RORs in type 1 diabetes in mice.
Sun Mar 01 00:00:00 EST 2015
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
BioMed research international
Tejón G,Manríquez V,De Calisto J,Flores-Santibáñez F,Hidalgo Y,Crisóstomo N,Fernández D,Sauma D,Mora JR,Bono MR,Rosemblatt M
12-7177 was used in Flow cytometry/Cell sorting to study the contribution of different factors to the reprogramming of iTregs into IL-17-producing cells, showing that vitamin A impairs reprogramming during intestinal inflammation.
Fri Sep 02 00:00:00 EDT 2016
Induction of Th17 cells by segmented filamentous bacteria in the murine intestine.
Journal of immunological methods
Farkas AM,Panea C,Goto Y,Nakato G,Galan-Diez M,Narushima S,Honda K,Ivanov II
12-7177 was used in Flow cytometry/Cell sorting to study the ability of segmented filamentous bacteria (SFB) to modulate the host immune system through induction of IgA and Th17 cells, and examine the kinetics of SFB colonisation and Th17 cell induction.
Mon Jun 01 00:00:00 EDT 2015
BTLA associates with increased Foxp3 expression in CD4(+) T cells in dextran sulfate sodium-induced colitis.
International journal of clinical and experimental pathology
Zhang HX,Zhu B,Fu XX,Zeng JC,Zhang JA,Wang WD,Kong B,Xiang WY,Zhong J,Wang CY,Zheng XB,Xu JF
12-7177 was used in Flow cytometry/Cell sorting to study the role of BLTA in ulcerative colitis, showing that the frequency Foxp3-expressing BLTA+CD4(+) T cells from the lamina propria was higher in mice with colitis, and treatment downregulated Foxp3 and IL-17 in BTLA+ cells.
Tue Mar 01 00:00:00 EST 2016
KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.
Nature communications
Kamimura D,Katsunuma K,Arima Y,Atsumi T,Jiang JJ,Bando H,Meng J,Sabharwal L,Stofkova A,Nishikawa N,Suzuki H,Ogura H,Ueda N,Tsuruoka M,Harada M,Kobayashi J,Hasegawa T,Yoshida H,Koseki H,Miura I,Wakana S,Nishida K,Kitamura H,Fukada T,Hirano T,Murakami M
12-7177 was used in Flow cytometry/Cell sorting to investigate the mechanism by which KDEL receptor 1 regulates the integration of stress responses in T cells.
Wed Jun 17 00:00:00 EDT 2015
Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages.
PloS one
Lee SW,Park HJ,Jeon SH,Lee C,Seong RH,Park SH,Hong S
12-7177 was used in Flow cytometry/Cell sorting to investigate the role of a SWI3-related gene in experimental autoimmune encephalomyelitis development.
Mon Apr 11 00:00:00 EDT 2016
Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-κB.
PloS one
Min HK,Kim SM,Baek SY,Woo JW,Park JS,Cho ML,Lee J,Kwok SK,Kim SW,Park SH
12-7177 was used in Immunofluorescence to investigate the anti-arthritic effects of anthocyanin extracted from black soybean seed coats in both murine and human cells.
Tue Jun 14 00:00:00 EDT 2016
Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-κB.
PloS one
Min HK,Kim SM,Baek SY,Woo JW,Park JS,Cho ML,Lee J,Kwok SK,Kim SW,Park SH
12-7177 was used in Immunofluorescence to investigate the anti-arthritic effects of anthocyanin extracted from black soybean seed coats in both murine and human cells.
Tue Jun 14 00:00:00 EDT 2016
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Nature immunology
Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T
12-7177 was used in an ELISA assay to investigate how the adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells.
Thu May 01 00:00:00 EDT 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
12-7177 was used in Flow cytometry/Cell sorting to study how inflammatory microenvironment-induced autophagy can downregulate the immunosuppressive function of mesenchymal stem cells.
Tue Jul 01 00:00:00 EDT 2014
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Mucosal immunology
Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M
12-7177 was used in Flow cytometry/Cell sorting to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.
Sat Nov 01 00:00:00 EDT 2014
IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing γδ T cells.
The Journal of investigative dermatology
Yoshiki R,Kabashima K,Honda T,Nakamizo S,Sawada Y,Sugita K,Yoshioka H,Ohmori S,Malissen B,Tokura Y,Nakamura M
12-7177 was used in Flow cytometry/Cell sorting to clarify the role of Langerhans cells in psoriasis.
Tue Jul 01 00:00:00 EDT 2014
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
European journal of immunology
Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE
12-7177-81 was used in Flow cytometry/Cell sorting to examine the role of CD4(+) T-cell-expressed TLR2 in Mycobacterium tuberculosis (MTB) Ag-specific T-cell priming and in protection against MTB infection in vivo.
Thu May 01 00:00:00 EDT 2014
Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Fujiwara H,Maeda Y,Kobayashi K,Nishimori H,Matsuoka K,Fujii N,Kondo E,Tanaka T,Chen L,Azuma M,Yagita H,Tanimoto M
12-7177 was used in Immunofluorescence to clarify that programed death-ligand 1 deficiency in host tissues, not hematopoietic cells, is associated with exacerbated chronic graft-versus-host disease.
Mon Sep 01 00:00:00 EDT 2014
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J
12-7177 was used in Flow cytometry/Cell sorting to investigate the source and regulation of the IL-17 surge in the liver microenvironment that occurs early in the response to viral infection.
Tue Apr 01 00:00:00 EDT 2014
Increased Th17 cells in flow cytometer-sorted CD45RO-positive memory CD4 T cells from patients with systemic lupus erythematosus.
Lupus science & medicine
Liu MF,Wang CR
12-7177 was used in Flow cytometry/Cell sorting to show that increased frequencies of Th17 cells positively correlate with disease activity and proteinuria in SLE patients, confirming the dysregulation of Th17/IL-17 in SLE.
Thu Jan 01 00:00:00 EST 2015
Antagonizing arachidonic acid-derived eicosanoids reduces inflammatory Th17 and Th1 cell-mediated inflammation and colitis severity.
Mediators of inflammation
Monk JM,Turk HF,Fan YY,Callaway E,Weeks B,Yang P,McMurray DN,Chapkin RS
12-7177 was used in Flow cytometry/Cell sorting to investigate the relationship between PGE2 levels and Th17 cells in regard to disease outcomes in a mouse model of colitis.
Wed Apr 08 00:00:00 EDT 2015
Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS.
The Journal of biological chemistry
Mueller AM,Yoon BH,Sadiq SA
12-7177 was used in Flow cytometry/Cell sorting to assess the potential proinflammatory role of hyaluronan in experimental autoimmune encephalomyelitis.
Fri Aug 15 00:00:00 EDT 2014
Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.
PloS one
Ikeda T,Hirata S,Takamatsu K,Haruta M,Tsukamoto H,Ito T,Uchino M,Ando Y,Nagafuchi S,Nishimura Y,Senju S
12-7177 was used in Flow cytometry/Cell sorting to investigate the effect of embryonic stem cell-derived dendritic cells on autoimmunity, showing that suppression of Th1-mediated autoimmunity occurs in NOD and EAE mice.
Thu Dec 17 00:00:00 EST 2015
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Nature immunology
Bermejo DA,Jackson SW,Gorosito-Serran M,Acosta-Rodriguez EV,Amezcua-Vesely MC,Sather BD,Singh AK,Khim S,Mucci J,Liggitt D,Campetella O,Oukka M,Gruppi A,Rawlings DJ
12-7177 was used in Flow cytometry/Cell sorting to study how the generation of IL-17 B cells may be a feature of innate immune responses required for pathogen control or IL-17-mediated autoimmunity.
Wed May 01 00:00:00 EDT 2013
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Nature immunology
Mascanfroni ID,Yeste A,Vieira SM,Burns EJ,Patel B,Sloma I,Wu Y,Mayo L,Ben-Hamo R,Efroni S,Kuchroo VK,Robson SC,Quintana FJ
12-7177 was used in Flow cytometry/Cell sorting to assess the regulation of T cells by dendritic cells.
Tue Oct 01 00:00:00 EDT 2013
Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells.
British journal of pharmacology
Rouse M,Singh NP,Nagarkatti PS,Nagarkatti M
12-7177 was used in an ELISA assay to demonstrate that I3C and DIM may serve as novel therapeutics to suppress neuroinflammation seen during MS through activation of AhR.
Mon Jul 01 00:00:00 EDT 2013
A bacterial glycan core linked to surface (S)-layer proteins modulates host immunity through Th17 suppression.
Mucosal immunology
Settem RP,Honma K,Nakajima T,Phansopa C,Roy S,Stafford GP,Sharma A
12-7177 was used in Flow cytometry/Cell sorting to show how the glycan core of Tannerella forsythia acts to modulate the immune response in mice via dendritic cell effector functions.
Fri Mar 01 00:00:00 EST 2013
The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Chen Z,Kim SJ,Chamberlain ND,Pickens SR,Volin MV,Volkov S,Arami S,Christman JW,Prabhakar BS,Swedler W,Mehta A,Sweiss N,Shahrara S
12-7177 was used in Flow cytometry/Cell sorting to study the role of IL7/IL7R in myeloid cells of rheumatoid arthritis and collagen induced arthritis.
Wed May 15 00:00:00 EDT 2013
Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration.
Journal of immunology (Baltimore, Md. : 1950)
Zhang F,Wei W,Chai H,Xie X
12-7177 was used in Flow cytometry/Cell sorting to investigate the effect of aurintricarboxylic acid (ATA) on experimental autoimmune encephalomyelitis (EAE), showing that ATA ameliorates EAE by blocking chemokine-mediated pathogenic cell migration and infiltration.
Fri Feb 01 00:00:00 EST 2013
The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis.
Immunobiology
Rouse M,Nagarkatti M,Nagarkatti PS
12-7177 was used in Flow cytometry/Cell sorting to investigate the effect of administration of IL-2 on the development of EAE, showing that pre-treatment causes significant amelioration of EAE.
Mon Apr 01 00:00:00 EDT 2013
Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.
The Journal of biological chemistry
Wong LY,Hatfield JK,Brown MA
12-7177 was used in Flow cytometry/Cell sorting to investigate the factors that influence the development of Th17 cells, showing that lineage gene expression is set by Ikaros.
Fri Dec 06 00:00:00 EST 2013
Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease.
PloS one
Coursey TG,Gandhi NB,Volpe EA,Pflugfelder SC,de Paiva CS
12-7177 was used in Flow cytometry/Cell sorting to highlight the interaction of T cell chemokine receptors and chemokine ligand expression on epithelial cells in dry eye pathogenesis.
Fri Aug 08 00:00:00 EDT 2014
Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice.
Journal of the American Heart Association
Yu K,Zhu P,Dong Q,Zhong Y,Zhu Z,Lin Y,Huang Y,Meng K,Ji Q,Yi G,Zhang W,Wu B,Mao Y,Cheng P,Zhao X,Mao X,Zeng Q
12-7177 was used in Flow cytometry/Cell sorting to examine the phenotype of TSLP-conditioned bone marrow dendritic cells of apolipoprotein E-deficient mice and their capacity to induce the differentiation of Tregs.
Wed Aug 28 00:00:00 EDT 2013
A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.
The Journal of experimental medicine
DePaolo RW,Kamdar K,Khakpour S,Sugiura Y,Wang W,Jabri B
12-7177 was used in Flow cytometry/Cell sorting to study the role of TLR1 in TH17 cell responses during Yersinia enterocolitica infection.
Mon Jul 30 00:00:00 EDT 2012
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon.
The Journal of experimental medicine
Rivollier A,He J,Kole A,Valatas V,Kelsall BL
12-7177 was used in Immunocytochemistry to demonstrate the dual capacity of Ly6C(hi) blood MOs, which is dictated by microenvironmental conditions.
Mon Jan 16 00:00:00 EST 2012
CD4 T cells play important roles in maintaining IL-17-producing γδ T-cell subsets in naive animals.
Immunology and cell biology
Do JS,Visperas A,O'Brien RL,Min B
12-7177 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying the regulation of αβ and γδ T-cell homeostasis, showing that CD4 T cells play important roles in maintaining IL-17-producing subsets.
Sun Apr 01 00:00:00 EDT 2012
Donor B cells in transplants augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Young JS,Wu T,Chen Y,Zhao D,Liu H,Yi T,Johnston H,Racine J,Li X,Wang A,Todorov I,Zeng D
12-7177 was used in Flow cytometry/Cell sorting to investigate the mechanisms whereby donor B cells augment chronic graft-versus-host disease (cGVHD) pathogenesis, showing that B cells augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like cGVHD.
Sun Jul 01 00:00:00 EDT 2012
Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Gowdy KM,Cardona DM,Nugent JL,Giamberardino C,Thomas JM,Mukherjee S,Martinu T,Foster WM,Plevy SE,Pastva AM,Wright JR,Palmer SM
12-7177 was used in Flow cytometry/Cell sorting to hypothesize a central role for the collectin surfactant protein A (SP-A) in regulating the development of Graft-versus-host disease after allogeneic BMT.
Tue May 15 00:00:00 EDT 2012
Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Oh S,Aitken M,Simons DM,Basehoar A,Garcia V,Kropf E,Caton AJ
12-7177 was used in Flow cytometry/Cell sorting to investigate why CD4(+)CD25(+)Foxp3(+) Tregs allow organ-specific autoimmunity, showing that polyclonal Tregs suppressed Th17 cell formation and prevented arthritis development, but clonotypic Tregs did not, indicating that diverse TCR specificities are required.
Tue May 01 00:00:00 EDT 2012
Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells.
ACS chemical biology
Solt LA,Kumar N,He Y,Kamenecka TM,Griffin PR,Burris TP
12-7177 was used in Flow cytometry/Cell sorting to evaluate the specificity of a synthetic compound for RORγ and its effects on Th17 and Treg cell development.
Fri Sep 21 00:00:00 EDT 2012
Host response signature to Staphylococcus aureus alpha-hemolysin implicates pulmonary Th17 response.
Infection and immunity
Frank KM,Zhou T,Moreno-Vinasco L,Hollett B,Garcia JG,Bubeck Wardenburg J
12-7177 was used in Flow cytometry/Cell sorting to evaluate the transcriptomic response to Hla-secreting staphylococci infection in humans.
Sat Sep 01 00:00:00 EDT 2012
Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation.
The Journal of biological chemistry
Mishra AK,Alves JE,Krumbach K,Nigou J,Castro AG,Geurtsen J,Eggeling L,Saraiva M,Besra GS
12-7177 was used in Flow cytometry/Cell sorting to study the implications of structural variations on TLR2 ligands for the development of T helper (Th) cell responses.
Fri Dec 28 00:00:00 EST 2012
Vaccination with immunotherapeutic Listeria monocytogenes induces IL-17(+) γδ T cells in a murine model for HPV associated cancer.
Oncoimmunology
Guirnalda PD,Paterson Y
12-7177 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 in Listeria based immunotherapy.
Sat Sep 01 00:00:00 EDT 2012
Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis.
BMC neuroscience
Müller AM,Jun E,Conlon H,Sadiq SA
12-7177 was used in Flow cytometry/Cell sorting to study how SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity and its neutralization may be beneficial for EAE.
Wed Mar 21 00:00:00 EDT 2012
MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1.
PloS one
Yao R,Ma YL,Liang W,Li HH,Ma ZJ,Yu X,Liao YH
12-7177 was used in Flow cytometry/Cell sorting to investigate the role of miR-155 in the mechanisms involved in CD4(+) CD25(+) regulatory T (Treg)/T helper (Th)17 cell differentiation and function.
Thu Mar 28 00:00:00 EDT 2013
IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression.
Blood
Milpied P,Massot B,Renand A,Diem S,Herbelin A,Leite-de-Moraes M,Rubio MT,Hermine O
12-7177 was used in Flow cytometry/Cell sorting to determine the function of recent thymic emigrant invariant natural killer (RTE TiNKT) cells in naive mice.
Thu Sep 15 00:00:00 EDT 2011
Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Lal G,Yin N,Xu J,Lin M,Schroppel S,Ding Y,Marie I,Levy DE,Bromberg JS
12-7177 was used in an ELISA assay to investigate how different inflammatory signals affect Foxp3 expression and Tregs plasticity, showing that distinct signals have physiologically divergent effects on Foxp3 epigenetic regulation.
Tue Feb 01 00:00:00 EST 2011
Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner.
PLoS pathogens
Chatterjee S,Dwivedi VP,Singh Y,Siddiqui I,Sharma P,Van Kaer L,Chattopadhyay D,Das G
12-7177 was used in Flow cytometry/Cell sorting to provide evidence that early secreted antigenic target protein 6, expressed by the virulent M. tb strain H37Rv but not by BCG, promotes vaccine-enhancing Th17 cell responses.
Tue Nov 01 00:00:00 EDT 2011
Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation.
International immunopharmacology
Cao H,Lan Q,Shi Q,Zhou X,Liu G,Liu J,Tang G,Qiu C,Qiu C,Xu J,Fan H,Liu Z
Sun May 01 00:00:00 EDT 2011
Host basophils are dispensable for induction of donor T helper 2 cell differentiation and severity of experimental graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Tawara I,Nieves E,Liu C,Evers R,Toubai T,Sun Y,Alrubaie M,Reddy P
12-7177 was used in Flow cytometry/Cell sorting to demonstrate that, in contrast to their role in inducing Th2 responses in certain contexts, basophils are dispensable for the induction of donor Th2 responses and for the severity of GVHD.
Thu Dec 01 00:00:00 EST 2011
Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation.
Journal of immunology (Baltimore, Md. : 1950)
Driessens G,Zheng Y,Locke F,Cannon JL,Gounari F,Gajewski TF
12-7177 was used in Flow cytometry/Cell sorting to investigate the mechanism by which β-catenin inhibits T cell activation and cytokine secretion in a mouse model.
Sat Jan 15 00:00:00 EST 2011
Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Newland S,Krejcí A,Phillips JM,Bray S,Cooke A
12-7177 was used in Flow cytometry/Cell sorting to examine the epigenetic mechanisms underpinning murine Th17 plasticity in vivo.
Tue Mar 15 00:00:00 EDT 2011
1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A.
Molecular and cellular biology
Joshi S,Pantalena LC,Liu XK,Gaffen SL,Liu H,Rohowsky-Kochan C,Ichiyama K,Yoshimura A,Steinman L,Christakos S,Youssef S
12-7177 was used in Flow cytometry/Cell sorting to investigate the role of 1,25-dihydroxyvitamin D(3) in experimental autoimmune encephalomyelitis.
Thu Sep 01 00:00:00 EDT 2011
Induction of autoimmune thyroiditis by depletion of CD4+CD25+ regulatory T cells in thyroiditis-resistant IL-17, but not interferon-gamma receptor, knockout nonobese diabetic-H2h4 mice.
Endocrinology
Horie I,Abiru N,Sakamoto H,Iwakura Y,Nagayama Y
12-7177 was used in Flow cytometry/Cell sorting to demonstrate that a robust Th1 immune response can by itself induce thyroiditis in otherwise thyroiditis-resistant IL-17 KO mice.
Tue Nov 01 00:00:00 EDT 2011
Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.
BMC immunology
Assi K,Patterson S,Dedhar S,Owen D,Levings M,Salh B
Mon Aug 01 00:00:00 EDT 2011
DX5+NKT cells display phenotypical and functional differences between spleen and liver as well as NK1.1-Balb/c and NK1.1+ C57Bl/6 mice.
BMC immunology
Werner JM,Busl E,Farkas SA,Schlitt HJ,Geissler EK,Hornung M
12-7177 was used in Immunocytochemistry to investigate the expression of several T cell and NK cell markers in spleen and liver DX5+NKT cell subsets in mice.
Fri Apr 29 00:00:00 EDT 2011
C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells.
European journal of immunology
Weaver DJ,Reis ES,Pandey MK,Köhl G,Harris N,Gerard C,Köhl J
12-7177 was used in Flow cytometry/Cell sorting to demonstrate that C5aR signalling in DCs affects the development of immune cells.
Mon Mar 01 00:00:00 EST 2010
A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice.
Journal of immunology (Baltimore, Md. : 1950)
Gao Q,Jiang Y,Ma T,Zhu F,Gao F,Zhang P,Guo C,Wang Q,Wang X,Ma C,Zhang Y,Chen W,Zhang L
12-7177 was used in Flow cytometry to evaluate the production and function of Th17 and Th1 cells in atherosclerotic-susceptible ApoE-knockout mice.
Mon Nov 15 00:00:00 EST 2010
Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
Journal of immunology (Baltimore, Md. : 1950)
Tan C,Aziz MK,Lovaas JD,Vistica BP,Shi G,Wawrousek EF,Gery I
12-7177 was used in Flow cytometry/Cell sorting to provide new information concerning Th9 cells and reveal their uniquenessin particular with regard to the unusual production kinetics of IL-9.
Wed Dec 01 00:00:00 EST 2010
Lack of TNFR p55 results in heightened expression of IFN-γ and IL-17 during the development of reactive arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Eliçabe RJ,Cargnelutti E,Serer MI,Stege PW,Valdez SR,Toscano MA,Rabinovich GA,Di Genaro MS
12-7177 was used in Flow cytometry/Cell sorting to show that, in the absence of TNFR p55 signaling, Th1 and Th17 effector cells may act in concert to sustain the inflammatory response in bacterial-induced arthritogenic processes.
Fri Oct 01 00:00:00 EDT 2010
The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Sivick KE,Schaller MA,Smith SN,Mobley HL
12-7177 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.
Mon Feb 15 00:00:00 EST 2010
Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Niess JH,Adler G
12-7177 was used in Flow cytometry/Cell sorting to study how the local accumulation of CX3CR1+ dendritic cells may depend on the enteric flora supporting inflammatory immune responses.
Mon Feb 15 00:00:00 EST 2010
Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ellestad KK,Tsutsui S,Noorbakhsh F,Warren KG,Yong VW,Pittman QJ,Power C
Wed Jul 01 00:00:00 EDT 2009
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation.
Journal of immunology (Baltimore, Md. : 1950)
Pierau M,Engelmann S,Reinhold D,Lapp T,Schraven B,Bommhardt UH
12-7177 was used in Flow cytometry/Cell sorting to indicate an important role of PKB signals on control of TGF-beta1-mediated T cell responses and, thereby, on tolerizing and inflammatory immune processes.
Sun Nov 15 00:00:00 EST 2009
The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling.
Journal of immunology (Baltimore, Md. : 1950)
Crabé S,Guay-Giroux A,Tormo AJ,Duluc D,Lissilaa R,Guilhot F,Mavoungou-Bigouagou U,Lefouili F,Cognet I,Ferlin W,Elson G,Jeannin P,Gauchat JF
12-7177 was used in Flow cytometry/Cell sorting to investigate potential functions of the cytokine subunit, p28, independent of EBI3.
Tue Dec 15 00:00:00 EST 2009
T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice.
Endocrinology
Horie I,Abiru N,Nagayama Y,Kuriya G,Saitoh O,Ichikawa T,Iwakura Y,Eguchi K
12-7177 was used in Flow cytometry/Cell sorting to indicate that both Th1 and Th17 cells are critical T(eff) subsets for the pathogenesis of thyroid lesions in spontaneous autoimmune thyroiditis seen in nonobese diabetic-H2(h4) mice.
Sun Nov 01 00:00:00 EDT 2009
Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models.
Experimental hematology
Banerjee ER,Jiang Y,Henderson WR,Latchman Y,Papayannopoulou T
12-7177 was used in Flow cytometry/Cell sorting to explore, to what extent, two molecular pathways control the development of structural airway remodelling in chronic asthma.
Mon Jun 01 00:00:00 EDT 2009
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype.
Proceedings of the National Academy of Sciences of the United States of America
Huber M,Brüstle A,Reinhard K,Guralnik A,Walter G,Mahiny A,von Löw E,Lohoff M
12-7177 was used in Flow cytometry/Cell sorting to investigate the role of IRF4 in Th17 differentiation, showing that it is essential for IL-21-mediated induction, amplification, and stabilisation of the Th17 phenotype.
Tue Dec 30 00:00:00 EST 2008
Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Vargas-Inchaustegui DA,Xin L,Soong L
12-7177 was used in Flow cytometry/Cell sorting to investigate whether Leishmania braziliensis infection efficiently triggers innate responses in dendritic cells and the subsequent adaptive immune responses for parasite clearance.
Sun Jun 01 00:00:00 EDT 2008
