Invitrogen

IL-17A Monoclonal Antibody (eBio17B7), Alexa Fluor™ 488, eBioscience™

IL-17A Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 96

IL-17A Antibody (53-7177-81) in Flow

Intracellular staining of splenocytes cultured under Th17-polarizing conditions followed by reactivation with PCell Stimulation Cocktail (plus protein transport inhibitors) (500X) (Product # 00-4975-03) for 5 hours with 0.25 µg of Rat IgG2a K Isotype Control APC (Product # 17-4321-81) (left) or 0.25 µg of Anti-Mouse/Rat IL-17A Alexa Fluor® 488 (right) using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and protocol. Cells in the lymphocyte gate were used for analysis.

IL-17A Antibody in Immunohistochemistry (IHC)

IL-17A Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC)

IL-17A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

IL-17A Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

IL-17A Antibody in Flow Cytometry, ELISA (Flow, ELISA)

Product Image Gallery

Product Details

53-7177-81

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-Dependent

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.5 µg/test

View 83 publications 83 publications

ELISA (ELISA)

View 3 publications 3 publications

Functional Assay (Functional)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), Alexa Fluor™ 488, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

eBio17B7

Conjugate

Alexa Fluor™ 488 Alexa Fluor™ 488 Alexa Fluor™ 488

Excitation/Emission Max

499/520 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_763579

Product Specific Information

Description: The eBio17B7 antibody reacts with mouse and rat IL-17A with no recognition of IL-17F. Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. The cDNA encoding human IL-17A was isolated from a library of CD4+ T cells; the encoded protein exhibits 72 percent amino acid identity with HVS13, an open reading frame from a T lymphotropic Herpesvirus saimiri, and 63 percent with mouse CTLA-8 (cytotoxic T-lymphocyte associated antigen-8). Human IL-17A exists as glycosylated 20-30 kD homodimers. High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells. IL-17A enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor.

IL-23-dependent, IL-17A-producing CD4+ T cells (Th-17 cells) have been identified as a unique subset of Th cells that develops along a pathway that is distinct from the Th1- and Th2- cell differentiation pathways. The hallmark effector molecules of Th1 and Th2 cells, e.g., IFN gamma and IL-4, have each been found to negatively regulate the generation of these Th-17 cells.

Applications Reported: This eBio17B7 antibody has been reported for use in intracellular staining followed by flow cytometric analysis.

Applications Tested: This eBio17B7 antibody has been tested by intracellular staining and flow cytometric analysis of restimulated, Th17-polarized mouse splenocytes using the Intracellular Fixation and Permeabilization Buffer Set (Product # 88-8824-00) and protocol. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Staining has been successfully done using the Foxp3 buffer system (Product # 00-5523-00).

Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis.

Cell communication and signaling : CCS

Lee AR,Woo JS,Lee SY,Lee YS,Jung J,Lee CR,Park SH,Cho ML

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EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis.

Arthritis research & therapy

Park JS,Yang SC,Jeong HY,Lee SY,Ryu JG,Choi JW,Kang HY,Kim SM,Hwang SH,Cho ML,Park SH

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Thu Nov 17 00:00:00 EST 2022

Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.

International journal of molecular sciences

Son SE,Koh JM,Im DS

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2022

Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element.

Immunity

Hall JA,Pokrovskii M,Kroehling L,Kim BR,Kim SY,Wu L,Lee JY,Littman DR

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Nov 08 00:00:00 EST 2022

Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators.

Nature communications

Dong X,Guthrie BGH,Alexander M,Noecker C,Ramirez L,Glasser NR,Turnbaugh PJ,Balskus EP

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Fri Dec 09 00:00:00 EST 2022

Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells.

EMBO reports

Lopez Krol A,Nehring HP,Krause FF,Wempe A,Raifer H,Nist A,Stiewe T,Bertrams W,Schmeck B,Luu M,Leister H,Chung HR,Bauer UM,Adhikary T,Visekruna A

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Dec 06 00:00:00 EST 2022

Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease.

Frontiers in cell and developmental biology

Hao C,Wang W,Zhan B,Wang Z,Huang J,Sun X,Zhu X

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Aug 03 00:00:00 EDT 2021

Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides.

Therapeutic advances in chronic disease

Pfeil J,Simonetti M,Lauer U,von Thülen B,Durek P,Poulsen C,Pawlowska J,Kröger M,Krähmer R,Leenders F,Hoffmann U,Hamann A

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Tue Nov 07 00:00:00 EST 2023

The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice.

Mediators of inflammation

Chen J,Yang F,Shi S,Liu X,Qin F,Wei X,Huang Y,Liang W,Miao L

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Wed Dec 22 00:00:00 EST 2021

Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.

Experimental and therapeutic medicine

Zhang Y,Wang L,Li X,Geng J

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Sat May 01 00:00:00 EDT 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

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Sat Apr 03 00:00:00 EDT 2021

In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Kim GR,Kim WJ,Lim S,Lee HG,Koo JH,Nam KH,Kim SM,Park SD,Choi JM

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Thu Jul 01 00:00:00 EDT 2021

G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.

Nature communications

Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N

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The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.

Nature communications

Liu B,Huang J,Ashraf A,Rahaman O,Lou J,Wang L,Cai P,Wen J,Anwaar S,Liu X,Ni H,Ganguly D,Zhao J,Yang CY

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Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling.

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Tue Feb 22 00:00:00 EST 2022

ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.

Cell reports

Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF

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Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease.

Med (New York, N.Y.)

Matei DE,Menon M,Alber DG,Smith AM,Nedjat-Shokouhi B,Fasano A,Magill L,Duhlin A,Bitoun S,Gleizes A,Hacein-Bey-Abina S,Manson JJ,Rosser EC,Klein N,Blair PA,Mauri C

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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4⁺ T Cell Pathogenicity and Suppresses Autoimmunity.

Cell metabolism

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GRIM-19 Ameliorates Multiple Sclerosis in a Mouse Model of Experimental Autoimmune Encephalomyelitis with Reciprocal Regulation of IFNγ/Th1 and IL-17A/Th17 Cells.

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Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Immunohistochemistry

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Veterinary research

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Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate.

Veterinary research

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Mon Apr 20 00:00:00 EDT 2020

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Thu Aug 12 00:00:00 EDT 2021

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.

Cell death & disease

Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY

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Cell reports

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UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation.

PloS one

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M1 Macrophage Derived Exosomes Aggravate Experimental Autoimmune Neuritis via Modulating Th1 Response.

Frontiers in immunology

Du T,Yang CL,Ge MR,Liu Y,Zhang P,Li H,Li XL,Li T,Liu YD,Dou YC,Yang B,Duan RS

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Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.

Scientific reports

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Immunity

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53-7177 was used in Flow cytometry/Cell sorting to demonstrate group 3 innate lymphoid cells are regulated by the metabolite-sensing receptor Ffar2.

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Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation.

Therapeutic advances in chronic disease

Liu H,Gu R,Li W,Zhou W,Cong Z,Xue J,Liu Y,Wei Q,Zhou Y

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Sat Apr 09 00:00:00 EDT 2022

Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.

Mediators of inflammation

Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M

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Tue Jun 11 00:00:00 EDT 2019

IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.

Biology open

Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Jan 15 00:00:00 EST 2019

Therapeutic effect of gold nanoparticles on DSS-induced ulcerative colitis in mice with reference to interleukin-17 expression.

Scientific reports

Abdelmegid AM,Abdo FK,Ahmed FE,Kattaia AAA

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Immunohistochemistry

Mon Jul 15 00:00:00 EDT 2019

Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis.

Immunity

Grizotte-Lake M,Zhong G,Duncan K,Kirkwood J,Iyer N,Smolenski I,Isoherranen N,Vaishnava S

53-7177 was used in Flow cytometry/Cell sorting to define a regulatory circuit wherein bacterial regulation of IEC-intrinsic RA synthesis protects microbial communities in the gut from excessive immune activity, achieving a balance that prevents colonization by enteric pathogens.

Tue Dec 18 00:00:00 EST 2018

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

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Tue Feb 27 00:00:00 EST 2018

RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling.

EMBO reports

Lin W,Wang N,Zhou K,Su F,Jiang Y,Shou J,Liu H,Ma C,Qian Y,Wang K,Wang X

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Combined treatment with simvastatin and rapamycin attenuates cardiac allograft rejection through the regulation of T helper 17 and regulatory T cells.

Experimental and therapeutic medicine

Liu Y,Sun L,Chen W,Chuai J,Shang Y,Zhang D,Fu B,Tian H,Jiang S

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.

Evidence-based complementary and alternative medicine : eCAM

Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X

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Thu Oct 01 00:00:00 EDT 2020

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

eLife

Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R

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Mon Sep 10 00:00:00 EDT 2018

Vibrio vulnificus RtxA Is a Major Factor Driving Inflammatory T Helper Type 17 Cell Responses in vitro and in vivo.

Frontiers in immunology

Lee A,Kim MS,Cho D,Jang KK,Choi SH,Kim TS

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Mon Sep 30 00:00:00 EDT 2019

ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior.

Journal of neuroinflammation

Han L,Wang L,Tang S,Yuan L,Wu S,Du X,Xiang Y,Qu X,Liu H,Luo H,Qin X,Liu C

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Fri Aug 31 00:00:00 EDT 2018

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.

Nature communications

Li H,Yao Q,Mariscal AG,Wu X,Hülse J,Pedersen E,Helin K,Waisman A,Vinkel C,Thomsen SF,Avgustinova A,Benitah SA,Lovato P,Norsgaard H,Mortensen MS,Veng L,Rozell B,Brakebusch C

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Thu Apr 12 00:00:00 EDT 2018

Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.

JCI insight

Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S

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Thu Mar 22 00:00:00 EDT 2018

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.

Nature

Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR

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Thu Sep 28 00:00:00 EDT 2017

miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.

The Journal of clinical investigation

Li B,Wang X,Choi IY,Wang YC,Liu S,Pham AT,Moon H,Smith DJ,Rao DS,Boldin MP,Yang L

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Mon Oct 02 00:00:00 EDT 2017

Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.

Gut microbes

Jacobs JP,Lin L,Goudarzi M,Ruegger P,McGovern DP,Fornace AJ,Borneman J,Xia L,Braun J

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Mon Jan 02 00:00:00 EST 2017

Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.

Mucosal immunology

Qi X,Gurung P,Malireddi RK,Karmaus PW,Sharma D,Vogel P,Chi H,Green DR,Kanneganti TD

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Webb LM,Amici SA,Jablonski KA,Savardekar H,Panfil AR,Li L,Zhou W,Peine K,Karkhanis V,Bachelder EM,Ainslie KM,Green PL,Li C,Baiocchi RA,Guerau-de-Arellano M

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in ELISA

Wed Feb 15 00:00:00 EST 2017

PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Webb LM,Amici SA,Jablonski KA,Savardekar H,Panfil AR,Li L,Zhou W,Peine K,Karkhanis V,Bachelder EM,Ainslie KM,Green PL,Li C,Baiocchi RA,Guerau-de-Arellano M

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in ELISA

Wed Feb 15 00:00:00 EST 2017

Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance.

Molecular medicine reports

Li Y,Li H,Cao Y,Wu F,Ma W,Wang Y,Sun S

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17‑mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro.

Molecular medicine reports

Ding FM,Liao RM,Chen YQ,Xie GG,Zhang PY,Shao P,Zhang M

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Sat Jul 01 00:00:00 EDT 2017

Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

EBioMedicine

Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.

Scientific reports

Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Mon Feb 06 00:00:00 EST 2017

Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis.

International journal of molecular sciences

Takemiya T,Takeuchi C,Kawakami M

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Immunohistochemistry

Tue Dec 19 00:00:00 EST 2017

Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis.

International journal of molecular sciences

Takemiya T,Takeuchi C,Kawakami M

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Immunohistochemistry

Tue Dec 19 00:00:00 EST 2017

Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice.

JCI insight

Robert R,Ang C,Sun G,Juglair L,Lim EX,Mason LJ,Payne NL,Bernard CC,Mackay CR

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Thu Aug 03 00:00:00 EDT 2017

Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells.

Frontiers in pharmacology

Li M,Gao J,Tang Y,Liu M,Wu S,Qu K,Long X,Li H,Liu M,Liu Y,Yuan J,Mao L,Liu Y,Zheng X,Wang E,Wang J,Yang Y

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.

JCI insight

Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Thu Aug 03 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Cutaneous Leishmaniasis Induces a Transmissible Dysbiotic Skin Microbiota that Promotes Skin Inflammation.

Cell host & microbe

Gimblet C,Meisel JS,Loesche MA,Cole SD,Horwinski J,Novais FO,Misic AM,Bradley CW,Beiting DP,Rankin SC,Carvalho LP,Carvalho EM,Scott P,Grice EA

53-7177-81 was used in Flow Cytometry to investigate the role of skin microbiota in cutaneous leishmaniasis and found that human patients infected with Leishmania braziliensis develop dysbiotic skin microbiota, characterized by increases in the abundance of Staphylococcus and/or Streptococcus.

Wed Jul 12 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Nuclear receptor expression atlas in BMDCs: Nr4a2 restricts immunogenicity of BMDCs and impedes EAE.

European journal of immunology

Saini A,Mahajan S,Gupta P

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

European journal of immunology

Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Molecular medicine reports

Gu L,Deng WS,Sun XF,Zhou H,Xu Q

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.

Autoimmunity

Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy.

Scientific reports

Kue CS,Kamkaew A,Voon SH,Kiew LV,Chung LY,Burgess K,Lee HB

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Thu Nov 17 00:00:00 EST 2016

Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22.

JCI insight

Abikhair M,Mitsui H,Yanofsky V,Roudiani N,Ovits C,Bryan T,Oberyszyn TM,Tober KL,Gonzalez J,Krueger JG,Felsen D,Carucci JA

53-7177 was used in Flow cytometry/Cell sorting to study how blockade of the IL-22 axis may be developed as a viable therapeutic option for catastrophic SCC.

Thu Jun 02 00:00:00 EDT 2016

Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.

PloS one

Watanabe N,Kaminuma O,Kitamura N,Hiroi T

53-7177 was used in Flow cytometry/Cell sorting to study whether Th17 and Tregs that promote and suppress inflammatory responses, respectively, work with or against each other in immune reactions, showing that cotransfer of Th17 and induced Tregs led to increased inflammation, and blockage of CTLA4 led to abrogation of this effect.

Mon Aug 01 00:00:00 EDT 2016

Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

Journal of the American Society of Nephrology : JASN

Micanovic R,Chitteti BR,Dagher PC,Srour EF,Khan S,Hato T,Lyle A,Tong Y,Wu XR,El-Achkar TM

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.

Proceedings of the National Academy of Sciences of the United States of America

Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2015

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Li JT,Melton AC,Su G,Hamm DE,LaFemina M,Howard J,Fang X,Bhat S,Huynh KM,O'Kane CM,Ingram RJ,Muir RR,McAuley DF,Matthay MA,Sheppard D

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus.

PloS one

Wang XY,Huang ZX,Chen YG,Lu X,Zhu P,Wen K,Fu N,Liu BY

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue May 24 00:00:00 EDT 2016

Upregulation of Programmed Death-1 and Its Ligand in Cardiac Injury Models: Interaction with GADD153.

PloS one

Baban B,Liu JY,Qin X,Weintraub NL,Mozaffari MS

53-7177 was used in Flow cytometry/Cell sorting to suggest that upregulation of the PD-1/PD-L1 pathway mediates tissue damage, likely through a paracrine mechanism.

Tue Apr 12 00:00:00 EDT 2016

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

R-phycoerythrin-conjugated antibodies are inappropriate for intracellular staining of murine plasma cells.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Kim MS,Kim TS

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Wed May 01 00:00:00 EDT 2013

Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.

Human vaccines & immunotherapeutics

Wu B,Zou Q,Hu Y,Wang B

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2013

Halofuginone prevents estrogen-deficient osteoporosis in mice.

Journal of cellular biochemistry

Deselm CJ,Zou W,Teitelbaum SL

53-7177 was used in Flow cytometry/Cell sorting to report that the febrifugine derivative, halofuginone, a small molecule drug, reduces abundance of Th-17 cells in mice and prevents estrogen-deficient osteoporosis by diminishing bone resorption without impacting osteogenesis.

Mon Oct 01 00:00:00 EDT 2012

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Impact of dietary gluten on regulatory T cells and Th17 cells in BALB/c mice.

PloS one

Antvorskov JC,Fundova P,Buschard K,Funda DP

53-7177 was used in Flow cytometry/Cell sorting to study the effect of a gluten-free diet compared to a gluten-containing standard diet on selected T cell subsets in mice.

Mon Aug 20 00:00:00 EDT 2012

Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation.

Proceedings of the National Academy of Sciences of the United States of America

Hwang J,Kita R,Kwon HS,Choi EH,Lee SH,Udey MC,Morasso MI

53-7177 was used in Flow cytometry/Cell sorting to investigate the role of Distal-less 3 (Dlx3) in cutaneous biology and pathophysiology, showing that ablation is linked to IL-17-associated skin inflammation.

Tue Jul 12 00:00:00 EDT 2011

Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation.

International immunopharmacology

Cao H,Lan Q,Shi Q,Zhou X,Liu G,Liu J,Tang G,Qiu C,Qiu C,Xu J,Fan H,Liu Z

Sun May 01 00:00:00 EDT 2011

Early MyD88-dependent induction of interleukin-17A expression during Salmonella colitis.

Infection and immunity

Keestra AM,Godinez I,Xavier MN,Winter MG,Winter SE,Tsolis RM,Bäumler AJ

53-7177 was used in Flow cytometry/Cell sorting to demonstrate that myeloid differentiation primary response protein 88-dependent mechanisms are important in initiating early inflammatory responses during Salmonella colitis.

Mon Aug 01 00:00:00 EDT 2011

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire.

BMC immunology

Assi K,Patterson S,Dedhar S,Owen D,Levings M,Salh B

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Immunofluorescence

Mon Aug 01 00:00:00 EDT 2011

T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection.

PloS one

Tousif S,Singh Y,Prasad DV,Sharma P,Van Kaer L,Das G

Thu May 12 00:00:00 EDT 2011

Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Ellestad KK,Tsutsui S,Noorbakhsh F,Warren KG,Yong VW,Pittman QJ,Power C

Wed Jul 01 00:00:00 EDT 2009

IDO activates regulatory T cells and blocks their conversion into Th17-like T cells.

Journal of immunology (Baltimore, Md. : 1950)

Baban B,Chandler PR,Sharma MD,Pihkala J,Koni PA,Munn DH,Mellor AL

Published figure using IL-17A monoclonal antibody (Product # 53-7177-81) in Flow Cytometry

Sat Aug 15 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; il 17; IL-17; ILN; Interleukin; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); Interleukin-17A; Interleukin17A; R-IL-17-A

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Gene Aliases: CTLA-8; Ctla8; IL-17; IL-17A; Il17; Il17a

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UniProt ID: (Mouse) Q62386

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Entrez Gene ID: (Mouse) 16171, (Rat) 301289

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Function(s)

cytokine activity

Process(es)

inflammatory response positive regulation of necrotic cell death positive regulation of interleukin-23 production positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter cellular response to interleukin-1 cellular response to glucocorticoid stimulus fibroblast activation positive regulation of cytokine production involved in inflammatory response response to amino acid

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IL-17A Monoclonal Antibody (eBio17B7), Alexa Fluor™ 488, eBioscience™

IL-17A Antibody (53-7177-81) in Flow

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53-7177-81

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