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Invitrogen
IL-17Ra Polyclonal Antibody
FIGURE: 1 / 4
IL-17Ra Antibody (PA5-87597) in ICC/IF
Immunofluorescence analysis of Interleukin-17 receptor A was performed using 70% confluent log phase THP-1 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with IL-17Ra Polyclonal Antibody (Product # PA5-87597) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488... View More
Product Details
PA5-87597
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 33-320 of human IL17RA (NP_0551543)
Conjugate
Form
Liquid
Concentration
4.18 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804277
Product Specific Information
Positive Samples: HL-60, Mouse liver, Mouse kidney, Mouse lung, Mouse thymus, Rat liver; Cellular Location: Membrane, Single-pass type I membrane protein
Immunogen sequence: LRLLDHRALV CSQPGLNCTV KNSTCLDDSW IHPRNLTPSS PKDLQIQLHF AHTQQGDLFP VAHIEWTLQT DASILYLEGA ELSVLQLNTN ERLCVRFEFL SKLRHHHRRW RFTFSHFVVD PDQEYEVTVH HLPKPIPDGD PNHQSKNFLV PDCEHARMKV TTPCMSSGSL WDPNITVETL EAHQLRVSFT LWNESTHYQI LLTSFPHMEN HSCFEHMHHI PAPRPEEFHQ RSNVTLTLRN LKGCCRHQVQ IQPFFSSCLN DCLRHSATVS CPEMPDTPEP IPDYMPLW
Target Information
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD217; CDw217; IL-17 receptor A; IL-17RA; Interleukin-17 receptor A; MGC10262
Gene Aliases: AW538159; CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R; IL17RA; VDw217
UniProt ID: (Human) Q96F46, (Mouse) Q60943
Entrez Gene ID: (Human) 23765, (Rat) 312679, (Mouse) 16172
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
positive regulation of interleukin-23 production
defense response to fungus
granulocyte chemotaxis
fibroblast activation
positive regulation of cytokine production involved in inflammatory response
positive regulation of interleukin-5 secretion
positive regulation of interleukin-13 secretion
cellular response to cytokine stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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