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Invitrogen
IL-18 Monoclonal Antibody (7G8), eBioscience™
FIGURE: 1 / 1
IL-18 Antibody (BMS1042) in WB
Toxins 2023 -
Deoxynivalenol (DON) treatment affected the protein expression levels of TXNIP, inflammasomes, and pro-inflammatory cytokine. ( A ) Protein expression level of TXNIP was evaluated by Western blotting assay. ( B ) Protein expression levels of inflammasomes (NLRP3, ASC, and CASP1) were evaluated using Western blotting assay. ( C ) Protein expression level of IL-18 was evaluated by Western blotting assay. The ... View More
Product Details
BMS1042
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Pig
Published species
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
7G8
Immunogen
Rec. Pig IL-18
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2-7.4
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_10598058
Product Specific Information
Description: BMS1042 (7G8) recognises natural and recombinant porcine IL-18. The antibody does not recognise porcine IL-1beta, IL-8, IL-12 or IFN-gamma, nor does it cross react with human or murine IL-18.
Applications Tested: ELISA, Western Blotting.
Target Information
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytokine; IFN-gamma-inducing factor; il 18; IL-1 gamma; IL-18; ILN; Interferon gamma-inducing factor; Interleukin; interleukin 18 (interferon-gamma-inducing factor); Interleukin-1 gamma; Interleukin-18; Interleukin18; MGC12320
Gene Aliases: IGIF; IL-18; IL18
UniProt ID: (Pig) O19073
Entrez Gene ID: (Pig) 397057
MAPK cascade
angiogenesis
inflammatory response
cell proliferation
positive regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of macrophage derived foam cell differentiation
positive regulation of phosphatidylinositol 3-kinase signaling
natural killer cell activation
lipopolysaccharide-mediated signaling pathway
activation of protein kinase B activity
interferon-gamma production
interleukin-6 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
interleukin-18-mediated signaling pathway
T-helper 1 cell cytokine production
positive regulation of activated T cell proliferation
neutrophil activation
natural killer cell mediated cytotoxicity
positive regulation of tyrosine phosphorylation of STAT protein
cholesterol homeostasis
positive regulation of T-helper 2 cell differentiation
negative regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
positive regulation of NF-kappaB transcription factor activity
positive regulation of NK T cell proliferation
positive regulation of protein kinase B signaling
triglyceride homeostasis
cellular response to organic cyclic compound
positive regulation of cold-induced thermogenesis
positive regulation of NIK/NF-kappaB signaling
positive regulation of T-helper 1 cell cytokine production
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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