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Invitrogen
IL-19 Monoclonal Antibody (RN19), eBioscience™
Product Details
14-7191-81
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
RN19
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1234935
Product Specific Information
Description: The RN19 antibody reacts with mouse interleukin-19 (IL-19), a member of the IL-10 family, which is secreted by activated keratinocytes and monocytes.
Applications Reported: The RN19 antibody has been reported for use in ELISA capture of mouse IL-19.
Applications Tested: The RN19 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of mouse Interleukin-19 (IL-19) in combination with a biotinylated polyclonal anti-mouse IL-19 antibody for detection. A suitable range of concentrations of this antibody for ELISA capture is 1.0-4 µg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 4000 pg/mL - 30 pg/mL should be included in each ELISA plate.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: il 19; IL-19; ILN; Interleukin; Interleukin-19; Interleukin19; MDA-1
Gene Aliases: Il19
UniProt ID: (Mouse) Q8CJ70
Entrez Gene ID: (Mouse) 329244
apoptotic process
inflammatory response
immune response
interleukin-6 biosynthetic process
positive regulation of JAK-STAT cascade
reactive oxygen species metabolic process
positive regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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