Product References
Dihydromyricetin Protects Intestinal Barrier Integrity by Promoting IL-22 Expression in ILC3s through the AMPK/SIRT3/STAT3 Signaling Pathway.
Nutrients
Zhou J,Yue J,Yao Y,Hou P,Zhang T,Zhang Q,Yi L,Mi M
Published figure using IL-22 monoclonal antibody (Product # 12-7221-82) in Flow Cytometry
Tue Jan 10 00:00:00 EST 2023
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
12-7221-82 was used in Flow cytometry/Cell sorting to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 EST 2022
Organoids capture tissue-specific innate lymphoid cell development in mice and humans.
Cell reports
Jowett GM,Read E,Roberts LB,Coman D,Vilà González M,Zabinski T,Niazi U,Reis R,Trieu TJ,Danovi D,Gentleman E,Vallier L,Curtis MA,Lord GM,Neves JF
12-7221-82 was used in Flow Cytometry to demonstrate that human epithelial cells recapitulate maturation of ILC from a stringent systemic human ILCP population, but only when the organoid-associated stromal cells are depleted.
Tue Aug 30 00:00:00 EDT 2022
Whole-genome profiling of DNA methylation and hydroxymethylation identifies distinct regulatory programs among innate lymphocytes.
Nature immunology
Peng V,Xing X,Bando JK,Trsan T,Di Luccia B,Collins PL,Li D,Wang WL,Lee HJ,Oltz EM,Wang T,Colonna M
12-7221-82 was used in Flow cytometry/Cell sorting to provide a powerful resource for studying innate lymphocyte epigenetic regulation and decode the regulatory logic governing their identity.
Fri Apr 01 00:00:00 EDT 2022
Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome.
Cell host & microbe
Dallari S,Heaney T,Rosas-Villegas A,Neil JA,Wong SY,Brown JJ,Urbanek K,Herrmann C,Depledge DP,Dermody TS,Cadwell K
12-7221-82 was used in Flow cytometry/Cell sorting to expand an understanding of the immune space occupied by the enteric virome and underscore the importance of viral exposure events.
Wed Jun 09 00:00:00 EDT 2021
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
12-7221 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
6-Formylindolo (3, 2-b) Carbazole (FICZ)-mediated protection of gut barrier is dependent on T cells in a mouse model of alcohol combined with burn injury.
Biochimica et biophysica acta. Molecular basis of disease
Li X,Luck ME,Hammer AM,Cannon AR,Choudhry MA
12-7221-82 was used in Flow Cytometry to explore whether treatment of mice with 6-Formylindolo (3, 2-b) Carbazole restores T cell IL-22 release and protects intestine barrier following ethanol and burn injury.
Sun Nov 01 00:00:00 EDT 2020
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Nature communications
Yang W,Yu T,Huang X,Bilotta AJ,Xu L,Lu Y,Sun J,Pan F,Zhou J,Zhang W,Yao S,Maynard CL,Singh N,Dann SM,Liu Z,Cong Y
12-7221-82 was used in Flow Cytometry to demonstrate that microbiota-derived short-chain fatty acids (SCFAs) promote IL-22 production by CD4+ T cells and ILCs through G-protein receptor 41 (GPR41) and inhibiting histone deacetylase (HDAC).
Tue Sep 08 00:00:00 EDT 2020
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Nature communications
Yang W,Yu T,Huang X,Bilotta AJ,Xu L,Lu Y,Sun J,Pan F,Zhou J,Zhang W,Yao S,Maynard CL,Singh N,Dann SM,Liu Z,Cong Y
12-7221-82 was used in Flow Cytometry to demonstrate that microbiota-derived short-chain fatty acids (SCFAs) promote IL-22 production by CD4+ T cells and ILCs through G-protein receptor 41 (GPR41) and inhibiting histone deacetylase (HDAC).
Tue Sep 08 00:00:00 EDT 2020
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
12-7221 was used in Flow cytometry/Cell sorting to suggest a revised model for ILC differentiation that redefines the cell-fate potential of helper-ILC-restricted Zbtb16+ ILCPs.
Tue Apr 16 00:00:00 EDT 2019
High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation.
Immunity
Zhang D,Jin W,Wu R,Li J,Park SA,Tu E,Zanvit P,Xu J,Liu O,Cain A,Chen W
12-7221-82 was used in Flow Cytometry to reveal a previously unrecognized mechanism underlying the adverse effects of high glucose intake in the pathogenesis of autoimmunity and inflammation.
Tue Oct 15 00:00:00 EDT 2019
Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis.
Cell reports
Wang B,Lim JH,Kajikawa T,Li X,Vallance BA,Moutsopoulos NM,Chavakis T,Hajishengallis G
12-7221 was used in Flow cytometry/Cell sorting to conclude that β2-integrins are required for protective IL-1β-dependent IL-22 responses in colitis, and the identified mechanism may underlie the association of human LAD1 with colitis.
Tue Feb 05 00:00:00 EST 2019
Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis.
Cell reports
Wang B,Lim JH,Kajikawa T,Li X,Vallance BA,Moutsopoulos NM,Chavakis T,Hajishengallis G
12-7221 was used in Flow cytometry/Cell sorting to conclude that β2-integrins are required for protective IL-1β-dependent IL-22 responses in colitis, and the identified mechanism may underlie the association of human LAD1 with colitis.
Tue Feb 05 00:00:00 EST 2019
A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence.
Immunity
Mamedov MR,Scholzen A,Nair RV,Cumnock K,Kenkel JA,Oliveira JHM,Trujillo DL,Saligrama N,Zhang Y,Rubelt F,Schneider DS,Chien YH,Sauerwein RW,Davis MM
12-7221-82 was used in Flow Cytometry to point to an M-CSF-producing γδ T cell subset that fulfills a specialized protective role in the later stage of malaria infection when αβ T cells have declined.
Tue Feb 20 00:00:00 EST 2018
Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis.
Immunity
Grizotte-Lake M,Zhong G,Duncan K,Kirkwood J,Iyer N,Smolenski I,Isoherranen N,Vaishnava S
12-7221 was used in Flow cytometry/Cell sorting to define a regulatory circuit wherein bacterial regulation of IEC-intrinsic RA synthesis protects microbial communities in the gut from excessive immune activity, achieving a balance that prevents colonization by enteric pathogens.
Tue Dec 18 00:00:00 EST 2018
IL22 Promotes Kras-Mutant Lung Cancer by Induction of a Protumor Immune Response and Protection of Stemness Properties.
Cancer immunology research
Khosravi N,Caetano MS,Cumpian AM,Unver N,De la Garza Ramos C,Noble O,Daliri S,Hernandez BJ,Gutierrez BA,Evans SE,Hanash S,Alekseev AM,Yang Y,Chang SH,Nurieva R,Kadara H,Chen J,Ostrin EJ,Moghaddam SJ
12-7221 was used in Flow cytometry/Cell sorting to propose pharmacological targeting of IL22 as a potential therapeutic strategy in combination with conventional chemotherapy, immune checkpoint blockade, or other targeted therapies (e.g. MEK inhibition) for KRAS mutant lung cancer patients.
Sun Jul 01 00:00:00 EDT 2018
Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.
Mucosal immunology
Sun T,Rojas OL,Li C,Ward LA,Philpott DJ,Gommerman JL
12-7221 was used in Flow cytometry/Cell sorting to study the dendritic cell subset(s) that provoke antiviral responses within the gut.
Mon May 01 00:00:00 EDT 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
12-7221 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.
Mon May 01 00:00:00 EDT 2017
Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Yi P,Tang H,Soong L,Cong Y,Zhang K,Sun J
12-7221 was used in Flow cytometry/Cell sorting to determine the role of retinoic acid in IL-22 production during hepatitis infection.
Mon May 01 00:00:00 EDT 2017
A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection.
Scientific reports
Yi P,Liang Y,Yuan DMK,Jie Z,Kwota Z,Chen Y,Cong Y,Fan X,Sun J
12-7221-82 was used in Flow Cytometry to reveal a significant effect of the IL-23/PI3K/mTORC1 axis on regulating IL-22 production and also identify a novel role of IL-22 in controlling antiviral T cell responses in the non-lymphoid and lymphoid organs during acute and persistent viral infections.
Tue Jun 20 00:00:00 EDT 2017
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.
The Journal of experimental medicine
Yoon J,Leyva-Castillo JM,Wang G,Galand C,Oyoshi MK,Kumar L,Hoff S,He R,Chervonsky A,Oppenheim JJ,Kuchroo VK,van den Brink MR,Malefyt Rde W,Tessier PA,Fuhlbrigge R,Rosenstiel P,Terhorst C,Murphy G,Geha RS
12-7221 was used in Flow cytometry/Cell sorting to elucidate the mechanisms behind DC-derived IL-23 in a model of skin inflammation.
Mon Sep 19 00:00:00 EDT 2016
Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity.
The Journal of allergy and clinical immunology
Everaere L,Ait-Yahia S,Molendi-Coste O,Vorng H,Quemener S,LeVu P,Fleury S,Bouchaert E,Fan Y,Duez C,de Nadai P,Staels B,Dombrowicz D,Tsicopoulos A
12-7221 was used in Flow cytometry/Cell sorting to indicate that high-fat diet-induced obesity might exacerbate allergic airway inflammation through mechanisms involving ILC2s and ILC3s.
Tue Nov 01 00:00:00 EDT 2016
Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice.
Journal of immunology (Baltimore, Md. : 1950)
Baerenwaldt A,von Burg N,Kreuzaler M,Sitte S,Horvath E,Peter A,Voehringer D,Rolink AG,Finke D
12-7221 was used in Flow cytometry/Cell sorting to investigate the role of the Flt3 ligand in the development and regulation of innate lymphoid cells in fetal and adult mice.
Tue Mar 15 00:00:00 EDT 2016
IL-22 dampens the T cell response in experimental malaria.
Scientific reports
Sellau J,Alvarado CF,Hoenow S,Mackroth MS,Kleinschmidt D,Huber S,Jacobs T
12-7221 was used in Flow cytometry/Cell sorting to study IL-22 levels during plasmodial infection in mice and the effect on an adaptive immune response.
Fri Jun 17 00:00:00 EDT 2016
Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis.
Allergology international : official journal of the Japanese Society of Allergology
Arima K,Ohta S,Takagi A,Shiraishi H,Masuoka M,Ontsuka K,Suto H,Suzuki S,Yamamoto K,Ogawa M,Simmons O,Yamaguchi Y,Toda S,Aihara M,Conway SJ,Ikeda S,Izuhara K
12-7221 was used in Flow cytometry/Cell sorting to evaluate the role of periostin in epidermal hyperplasia by examining its expression in psoriasis patients and applying periostin-deficient mice to a psoriasis model.
Thu Jan 01 00:00:00 EST 2015
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Mucosal immunology
Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M
12-7221 was used in Flow cytometry/Cell sorting to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.
Sat Nov 01 00:00:00 EDT 2014
IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing γδ T cells.
The Journal of investigative dermatology
Yoshiki R,Kabashima K,Honda T,Nakamizo S,Sawada Y,Sugita K,Yoshioka H,Ohmori S,Malissen B,Tokura Y,Nakamura M
12-7221 was used in Flow cytometry/Cell sorting to clarify the role of Langerhans cells in psoriasis.
Tue Jul 01 00:00:00 EDT 2014
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
12-7221 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease.
The Journal of experimental medicine
Molle C,Zhang T,Ysebrant de Lendonck L,Gueydan C,Andrianne M,Sherer F,Van Simaeys G,Blackshear PJ,Leo O,Goriely S
12-7221 was used in Flow cytometry/Cell sorting to highlight that control of IL23 mRNA stability by tristetraprolin (TTP) is necessary to avoid severe autoimmune inflammation.
Mon Aug 26 00:00:00 EDT 2013
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.
Human vaccines & immunotherapeutics
Wu B,Zou Q,Hu Y,Wang B
12-7221 was used in Flow cytometry/Cell sorting to investigate how IL-22 might be used as an effective adjuvant to enhance cellular immune responses during HBsAg DNA vaccination.
Tue Oct 01 00:00:00 EDT 2013
Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.
Immunity
Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK
12-7221 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.
Fri Apr 20 00:00:00 EDT 2012
Distinct requirements for T-bet in gut innate lymphoid cells.
The Journal of experimental medicine
Sciumé G,Hirahara K,Takahashi H,Laurence A,Villarino AV,Singleton KL,Spencer SP,Wilhelm C,Poholek AC,Vahedi G,Kanno Y,Belkaid Y,O'Shea JJ
12-7221 was used in Flow cytometry/Cell sorting to determine whether the transcription factor T-bet can control the development and function of a distinct interleukin-22-producing innate lymphoid cell subset.
Mon Dec 17 00:00:00 EST 2012
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
The Journal of experimental medicine
Cherrier M,Sawa S,Eberl G
12-7221 was used in Flow cytometry/Cell sorting to investigate the development of lymphoid tissue inducer (LTi) cells from common lymphoid progenitors (CLPs) in the fetal liver, showing that sequential changes in expression of Notch, Id2, and RORγt orchestrate the development of LTi cells.
Mon Apr 09 00:00:00 EDT 2012
Aryl Hydrocarbon Receptor-Mediated Perturbations in Gene Expression during Early Stages of CD4(+) T-cell Differentiation.
Frontiers in immunology
Rohlman D,Pham D,Yu Z,Steppan LB,Kerkvliet NI
12-7221 was used in Flow cytometry/Cell sorting to characterise the influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin-activated aryl hydrocarbon receptor on gene expression during CD4+ T-cell differentiation.
Thu Aug 23 00:00:00 EDT 2012
IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium.
Nature immunology
Ota N,Wong K,Valdez PA,Zheng Y,Crellin NK,Diehl L,Ouyang W
Sun Aug 28 00:00:00 EDT 2011
