Product References
Gut microbe-derived milnacipran enhances tolerance to gut ischemia/reperfusion injury.
Cell reports. Medicine
Deng F,Hu JJ,Lin ZB,Sun QS,Min Y,Zhao BC,Huang ZB,Zhang WJ,Huang WK,Liu WF,Li C,Liu KX
Published figure using IL-22 monoclonal antibody (Product # 17-7222-82) in Flow Cytometry
Tue Mar 21 00:00:00 EDT 2023
A cis-element at the Rorc locus regulates the development of type 3 innate lymphoid cells.
Frontiers in immunology
Chang D,Zhang H,Ge J,Xing Q,Guo X,Wang X,Dong C
17-7222-82 was used in Flow cytometry/Cell sorting to identify CNS9 as an essential cis-regulatory element controlling the lineage stability and plasticity of ILC3s through modulating expression levels of RORγt protein.
Tue Mar 28 00:00:00 EDT 2023
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.
The Journal of experimental medicine
Krzywinska E,Sobecki M,Nagarajan S,Zacharjasz J,Tambuwala MM,Pelletier A,Cummins E,Gotthardt D,Fandrey J,Kerdiles YM,Peyssonnaux C,Taylor CT,Sexl V,Stockmann C
17-7222-82 was used in Flow cytometry/Cell sorting to suggest that HIF-1α shapes the ILC phenotype in the gut.
Mon Feb 07 00:00:00 EST 2022
Interleukin-1β secretion induced by mucosa-associated gut commensal bacteria promotes intestinal barrier repair.
Gut microbes
Wu WH,Kim M,Chang LC,Assie A,Saldana-Morales FB,Zegarra-Ruiz DF,Norwood K,Samuel BS,Diehl GE
17-7222-82 was used in Flow cytometry/Cell sorting to demonstrate an unexpected role for commensal bacteria in promoting IL-1β secretion to support intestinal barrier repair.
Thu Feb 24 00:00:00 EST 2022
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.
iScience
Riding AM,Loudon KW,Guo A,Ferdinand JR,Lok LSC,Richoz N,Stewart A,Castro-Dopico T,Tuong ZK,Fiancette R,Bowyer GS,Fleming A,Gillman ES,Suchanek O,Mahbubani KT,Saeb-Parsy K,Withers D,Dougan G,Clare S,Clatworthy MR
17-7222-82 was used in Flow cytometry/Cell sorting to provide important insights into the orchestration and execution of type 17 immunity in bladder defense.
Fri Jul 15 00:00:00 EDT 2022
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity.
Cell
Leonardi I,Gao IH,Lin WY,Allen M,Li XV,Fiers WD,De Celie MB,Putzel GG,Yantiss RK,Johncilla M,Colak D,Iliev ID
17-7222-82 was used in Flow cytometry/Cell sorting to characterize the mycobiota biogeography along the gastrointestinal tract and identified a subset of fungi associated with the intestinal mucosa of mice and humans.
Thu Mar 03 00:00:00 EST 2022
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Cell
Hoang TN,Pino M,Boddapati AK,Viox EG,Starke CE,Upadhyay AA,Gumber S,Nekorchuk M,Busman-Sahay K,Strongin Z,Harper JL,Tharp GK,Pellegrini KL,Kirejczyk S,Zandi K,Tao S,Horton TR,Beagle EN,Mahar EA,Lee MYH,Cohen J,Jean SM,Wood JS,Connor-Stroud F,Stammen RL,Delmas OM,Wang S,Cooney KA,Sayegh MN,Wang L,Filev PD,Weiskopf D,Silvestri G,Waggoner J,Piantadosi A,Kasturi SP,Al-Shakhshir H,Ribeiro SP,Sekaly RP,Levit RD,Estes JD,Vanderford TH,Schinazi RF,Bosinger SE,Paiardini M
17-7222 was used in Flow cytometry/Cell sorting to investigate the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection.
Thu Jan 21 00:00:00 EST 2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications
Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L
Published figure using IL-22 monoclonal antibody (Product # 17-7222-82) in Flow Cytometry
Thu Jul 22 00:00:00 EDT 2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications
Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L
Published figure using IL-22 monoclonal antibody (Product # 17-7222-82) in Flow Cytometry
Thu Jul 22 00:00:00 EDT 2021
Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis.
Nature biomedical engineering
Ishihara A,Ishihara J,Watkins EA,Tremain AC,Nguyen M,Solanki A,Katsumata K,Mansurov A,Budina E,Alpar AT,Hosseinchi P,Maillat L,Reda JW,Kageyama T,Swartz MA,Yuba E,Hubbell JA
17-7222-82 was used in Flow Cytometry to show that, in mice with EAE, the accumulation and persistence in the lymph nodes and spleen of a systemically administered serum albumin (SA)-IL-4 fusion protein leads to higher efficacy in preventing disease development than the administration of wild-type IL-4 or of the clinically approved drug fingolimod.
Sat May 01 00:00:00 EDT 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
17-7222-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques.
Nature communications
Harper J,Huot N,Micci L,Tharp G,King C,Rascle P,Shenvi N,Wang H,Galardi C,Upadhyay AA,Villinger F,Lifson J,Silvestri G,Easley K,Jacquelin B,Bosinger S,Müller-Trutwin M,Paiardini M
17-7222 was used in Flow cytometry/Cell sorting to generate terminally differentiated blood natural killer cells (NKG2a/clowCD16+) with potent human leukocyte antigen-E-restricted activity in response to SIV envelope peptides.
Mon May 17 00:00:00 EDT 2021
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.
Cell reports
Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF
17-7222-82 was used in Flow cytometry/Cell sorting to demonstrate a critical role for antigen-presenting ILC3s in orchestrating immune tolerance in the airway by restricting pro-inflammatory T cell responses to both allergens and microbes.
Tue Nov 23 00:00:00 EST 2021
Single-cell multi-omics analysis presents the landscape of peripheral blood T-cell subsets in human chronic prostatitis/chronic pelvic pain syndrome.
Journal of cellular and molecular medicine
Zhang M,Liu Y,Chen J,Chen L,Meng J,Yang C,Yin S,Zhang X,Zhang L,Hao Z,Chen X,Liang C
Published figure using IL-22 monoclonal antibody (Product # 17-7222-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
A Central Role for Lipocalin-2 in the Adaptation to Short-Bowel Syndrome Through Down-Regulation of IL22 in Mice.
Cellular and molecular gastroenterology and hepatology
Zhang A,Sodhi CP,Wang M,Shores DR,Fulton W,Prindle T,Brosten S,O'Hare E,Lau A,Ding H,Jia H,Lu P,White JR,Hui J,Sears CL,Hackam DJ,Alaish SM
17-7222 was used in Flow cytometry/Cell sorting to lCN2 promotes inflammation and slows intestinal adaptation through changes in the microbiome and IL22 inhibition in a mouse SBS model.
Fri Jul 09 00:00:00 EDT 2021
A Central Role for Lipocalin-2 in the Adaptation to Short-Bowel Syndrome Through Down-Regulation of IL22 in Mice.
Cellular and molecular gastroenterology and hepatology
Zhang A,Sodhi CP,Wang M,Shores DR,Fulton W,Prindle T,Brosten S,O'Hare E,Lau A,Ding H,Jia H,Lu P,White JR,Hui J,Sears CL,Hackam DJ,Alaish SM
17-7222 was used in Flow cytometry/Cell sorting to lCN2 promotes inflammation and slows intestinal adaptation through changes in the microbiome and IL22 inhibition in a mouse SBS model.
Fri Jul 09 00:00:00 EDT 2021
Host immunology and rational immunotherapy for carbapenem-resistant Klebsiella pneumoniae infection.
JCI insight
Iwanaga N,Sandquist I,Wanek A,McCombs J,Song K,Kolls JK
17-7222 was used in Flow cytometry/Cell sorting to support the development of host-directed immunotherapy as an adjunct treatment to new antibiotics.
Thu Apr 23 00:00:00 EDT 2020
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
bioRxiv : the preprint server for biology
Hoang TN,Pino M,Boddapati AK,Viox EG,Starke CE,Upadhyay AA,Gumber S,Busman-Sahay K,Strongin Z,Harper JL,Tharp GK,Pellegrini KL,Kirejczyk S,Zandi K,Tao S,Horton TR,Beagle EN,Mahar EA,Lee MY,Cohen J,Jean SM,Wood JS,Connor-Stroud F,Stammen RL,Delmas OM,Wang S,Cooney KA,Sayegh MN,Wang L,Weiskopf D,Filev PD,Waggoner J,Piantadosi A,Kasturi SP,Al-Shakhshir H,Ribeiro SP,Sekaly RP,Levit RD,Estes JD,Vanderford TH,Schinazi RF,Bosinger SE,Paiardini M
17-7222 was used in Flow cytometry/Cell sorting to investigate the immunologic and virologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection.
Wed Sep 16 00:00:00 EDT 2020
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.
Cell reports
Castro-Dopico T,Fleming A,Dennison TW,Ferdinand JR,Harcourt K,Stewart BJ,Cader Z,Tuong ZK,Jing C,Lok LSC,Mathews RJ,Portet A,Kaser A,Clare S,Clatworthy MR
17-7222 was used in Flow cytometry/Cell sorting to identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis.
Tue Jul 07 00:00:00 EDT 2020
High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation.
Immunity
Zhang D,Jin W,Wu R,Li J,Park SA,Tu E,Zanvit P,Xu J,Liu O,Cain A,Chen W
17-7222-82 was used in Flow Cytometry to reveal a previously unrecognized mechanism underlying the adverse effects of high glucose intake in the pathogenesis of autoimmunity and inflammation.
Tue Oct 15 00:00:00 EDT 2019
Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells.
Immunity
Pokrovskii M,Hall JA,Ochayon DE,Yi R,Chaimowitz NS,Seelamneni H,Carriero N,Watters A,Waggoner SN,Littman DR,Bonneau R,Miraldi ER
17-7222 was used in Flow cytometry/Cell sorting to study regulatory interactions between transcription factors and genes within intestinal type 1, 2, and 3 innate lymphoid cells subsets.
Tue Jul 16 00:00:00 EDT 2019
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
17-7222-82 was used in PCR to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.
Tue Jan 15 00:00:00 EST 2019
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Immunity
Emgård J,Kammoun H,García-Cassani B,Chesné J,Parigi SM,Jacob JM,Cheng HW,Evren E,Das S,Czarnewski P,Sleiers N,Melo-Gonzalez F,Kvedaraite E,Svensson M,Scandella E,Hepworth MR,Huber S,Ludewig B,Peduto L,Villablanca EJ,Veiga-Fernandes H,Pereira JP,Flavell RA,Willinger T
17-7222 was used in Flow cytometry/Cell sorting to show that GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls ILC3 activity and intestinal homeostasis.
Tue Jan 16 00:00:00 EST 2018
The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.
Immunity
Metidji A,Omenetti S,Crotta S,Li Y,Nye E,Ross E,Li V,Maradana MR,Schiering C,Stockinger B
17-7222 was used in Flow cytometry/Cell sorting to study the role of the aryl hydrocarbon receptor pathway of intestinal epithelial cells in maintaining intestinal barrier integrity.
Tue Aug 21 00:00:00 EDT 2018
Inhibition of p38 MAPK in combination with ART reduces SIV-induced immune activation and provides additional protection from immune system deterioration.
PLoS pathogens
Chaudhary O,Narayan V,Lelis F,Linz B,Watkins M,Veazey R,Aldovini A
17-7222 was used in Flow cytometry/Cell sorting to conclude that the inhibitor PH-797804 significantly reduced, even if did not normalized, the immune activation parameters evaluated during ART treatment, improved preservation of critical populations of the immune system targeted by SIV, and increased the efficacy of ART treatment initiated in chronic infection to levels similar to those observed when initiated in acute infection but did not affect positively or negatively viral reservoirs.
Wed Aug 01 00:00:00 EDT 2018
CXCL4 is a novel inducer of human Th17 cells and correlates with IL-17 and IL-22 in psoriatic arthritis.
European journal of immunology
Affandi AJ,Silva-Cardoso SC,Garcia S,Leijten EFA,van Kempen TS,Marut W,van Roon JAG,Radstake TRDJ
17-7222 was used in Flow cytometry/Cell sorting to study whether CXCL4 plays a direct role in the induction of IL-17 production by human CD4+ T cells.
Thu Mar 01 00:00:00 EST 2018
CXCL4 is a novel inducer of human Th17 cells and correlates with IL-17 and IL-22 in psoriatic arthritis.
European journal of immunology
Affandi AJ,Silva-Cardoso SC,Garcia S,Leijten EFA,van Kempen TS,Marut W,van Roon JAG,Radstake TRDJ
17-7222 was used in Flow cytometry/Cell sorting to study whether CXCL4 plays a direct role in the induction of IL-17 production by human CD4+ T cells.
Thu Mar 01 00:00:00 EST 2018
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.
Frontiers in immunology
Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW
Published figure using IL-22 monoclonal antibody (Product # 17-7222-82) in Flow Cytometry
Thu Sep 26 00:00:00 EDT 2019
Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling.
PLoS pathogens
Seshadri S,Allan DSJ,Carlyle JR,Zenewicz LA
17-7222 was used in Flow cytometry/Cell sorting to study the effects of MAPK signalling pathways in group 3 innate immune lymphocytes using Bacillus anthracis.
Sun Oct 01 00:00:00 EDT 2017
Fecal Microbiota Transplantation, Commensal Escherichia coli and Lactobacillus johnsonii Strains Differentially Restore Intestinal and Systemic Adaptive Immune Cell Populations Following Broad-spectrum Antibiotic Treatment.
Frontiers in microbiology
Ekmekciu I,von Klitzing E,Neumann C,Bacher P,Scheffold A,Bereswill S,Heimesaat MM
17-7222 was used in Flow cytometry/Cell sorting to examine the ability of defined Gram-positive and Gram-negative intestinal commensal bacterial species, namely Escherichia coli and Lactobacillus johnsonii, respectively, to restore immune functions in mice that were immunosuppressed by antibiotics-induced microbiota depletion.
Wed Sep 30 00:00:00 EDT 2020
Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance.
Cell
Xiong H,Keith JW,Samilo DW,Carter RA,Leiner IM,Pamer EG
17-7222 was used in Flow cytometry/Cell sorting to demonstrate that inflammatory monocytes are recruited to the lungs of K. pneumoniae-infected mice, produce TNF, which increases IL-17-producing lymphoid cell numbers.
Thu Apr 21 00:00:00 EDT 2016
CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.
Nature immunology
Cibrian D,Saiz ML,de la Fuente H,Sánchez-Díaz R,Moreno-Gonzalo O,Jorge I,Ferrarini A,Vázquez J,Punzón C,Fresno M,Vicente-Manzanares M,Daudén E,Fernández-Salguero PM,Martín P,Sánchez-Madrid F
Published figure using IL-22 monoclonal antibody (Product # 17-7222-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques.
Mucosal immunology
Ortiz AM,Klase ZA,DiNapoli SR,Vujkovic-Cvijin I,Carmack K,Perkins MR,Calantone N,Vinton CL,Riddick NE,Gallagher J,Klatt NR,McCune JM,Estes JD,Paiardini M,Brenchley JM
17-7222 was used in Flow cytometry/Cell sorting to investigate methods to promote Th17 cell recovery in individuals infected with HIV, showing that IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in antiretroviral-treated, SIV-infected macaques.
Tue Mar 01 00:00:00 EST 2016
Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques.
PLoS pathogens
Ryan ES,Micci L,Fromentin R,Paganini S,McGary CS,Easley K,Chomont N,Paiardini M
17-7222 was used in Flow cytometry/Cell sorting to show that intestinal IL-17 producing cell function is severely impaired by SIV infection and is not fully normalized despite effective ART.
Mon Feb 01 00:00:00 EST 2016
Interleukin-22-Induced Antimicrobial Phospholipase A2 Group IIA Mediates Protective Innate Immunity of Nonhematopoietic Cells against Listeria monocytogenes.
Infection and immunity
Okita Y,Shiono T,Yahagi A,Hamada S,Umemura M,Matsuzaki G
17-7222 was used in Flow cytometry/Cell sorting to assess the influence of IL-22 on Listeria monocytogenes infection in hepatocytes.
Mon Feb 01 00:00:00 EST 2016
Lymphocyte Isolation, Th17 Cell Differentiation, Activation, and Staining.
Bio-protocol
Kumar P,Kolls JK
17-7222 was used in Flow cytometry/Cell sorting to describe the tools, reagents and procdedure for a Th17 cell differentiation method.
Mon Dec 05 00:00:00 EST 2016
Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.
The Journal of clinical investigation
Micci L,Ryan ES,Fromentin R,Bosinger SE,Harper JL,He T,Paganini S,Easley KA,Chahroudi A,Benne C,Gumber S,McGary CS,Rogers KA,Deleage C,Lucero C,Byrareddy SN,Apetrei C,Estes JD,Lifson JD,Piatak M,Chomont N,Villinger F,Silvestri G,Brenchley JM,Paiardini M
17-7222 was used in Flow cytometry/Cell sorting to investigate the effects of IL-21 administration on both inflammation and virus persistence in ART-treated, SIV-infected rhesus macaques.
Tue Dec 01 00:00:00 EST 2015
Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy.
Journal of immunology (Baltimore, Md. : 1950)
Rasouli J,Ciric B,Imitola J,Gonnella P,Hwang D,Mahajan K,Mari ER,Safavi F,Leist TP,Zhang GX,Rostami A
17-7222 was used in Flow cytometry/Cell sorting to characterise GM-CSF production by T cells of MS patients and to determine the effect of IFN-β therapy on its production.
Mon Jun 01 00:00:00 EDT 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
17-7222 was used in Flow cytometry/Cell sorting to show that the addition of antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Tue Sep 29 00:00:00 EDT 2015
The existence of Th22, pure Th17 and Th1 cells in CIN and Cervical Cancer along with their frequency variation in different stages of cervical cancer.
BMC cancer
Zhang W,Tian X,Mumtahana F,Jiao J,Zhang T,Croce KD,Ma D,Kong B,Cui B
17-7222 was used in Flow cytometry/Cell sorting to study the involvement of T-helper 22 cells in cervical cancer and cervical intraepithelial neoplasia.
Fri Oct 16 00:00:00 EDT 2015
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
The Journal of experimental medicine
Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR
17-7222 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection.
Mon Jul 28 00:00:00 EDT 2014
Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection.
Molecular medicine (Cambridge, Mass.)
Peng Y,Gao X,Yang J,Shekhar S,Wang S,Fan Y,Zhao W,Yang X
Published figure using IL-22 monoclonal antibody (Product # 17-7222-82) in Flow Cytometry
Thu Mar 20 00:00:00 EDT 2014
OMIP-022: Comprehensive assessment of antigen-specific human T-cell functionality and memory.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Graves AJ,Padilla MG,Hokey DA
Published figure using IL-22 monoclonal antibody (Product # 17-7222-82) in Flow Cytometry
Tue Jul 01 00:00:00 EDT 2014
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
Immunity
Kinnebrew MA,Buffie CG,Diehl GE,Zenewicz LA,Leiner I,Hohl TM,Flavell RA,Littman DR,Pamer EG
17-7222 was used in Flow cytometry/Cell sorting to demonstrate cytokine expression by certain DCs drives IL-22-dependent RegIIIγ production for protection from bacterial colonisation.
Fri Feb 24 00:00:00 EST 2012
Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection.
Mucosal immunology
Klatt NR,Estes JD,Sun X,Ortiz AM,Barber JS,Harris LD,Cervasi B,Yokomizo LK,Pan L,Vinton CL,Tabb B,Canary LA,Dang Q,Hirsch VM,Alter G,Belkaid Y,Lifson JD,Silvestri G,Milner JD,Paiardini M,Haddad EK,Brenchley JM
Thu Nov 01 00:00:00 EDT 2012
