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IL-28A/IL-28B Antibody (MA5-23902) in Neu
Neutralization of IL-28A/IL-28B in HepG2 human hepatocellular carcinoma cell line. Samples were incubated in IL-28A/IL-28B monoclonal antibody (Product # MA5-23902). Recombinant Mouse IL‚28B/IFN‚λ3 reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HepG2 human hepatocellular carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recombinant Mouse IL‚28B/IFN‚λ3 (400 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL‚28B/IFN‚λ3 Monoclonal Ant... View More
Product Details
MA5-23902
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2B
Class
Monoclonal
Type
Antibody
Clone
244716
Immunogen
E. coli-derived recombinant mouse IL-28B/IFN-lambda3 Asp20-Val193
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607558
Product Specific Information
In sandwich ELISAs, 100% cross-reactivity with recombinant mouse IL-28A/IFN-lambda 2 and no cross-reactivity with recombinant human (rh) IL-28A or rhIL-29 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
IL28 is a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IFN lambda2; IFN-lambda-2; IFN-lambda-3; IFN-lambda2; IL 28; IL 28 A; IL-28A; IL-28B; ILN; interferon alpha; Interferon lambda-2; Interferon lambda-3; Interferon lambda2; interferon-lambda2; Interleukin; interleukin 28; interleukin 28A; interleukin 28B; Interleukin-28A; Interleukin-28B
Gene Aliases: EG330496; IFL-1; Ifnl2; Ifnl3; IL-28A; IL-28B; Il28; Il28a; Il28b; INF-alpha; INF-lambda
UniProt ID: (Mouse) Q4VK74, (Mouse) Q8CGK6
Entrez Gene ID: (Mouse) 330496, (Mouse) 338374
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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