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Invitrogen
IL-29 Recombinant Rabbit Monoclonal Antibody (001)
FIGURE: 1 / 1
IL-29 Antibody (MA5-30682) in WB
Infectious agents and cancer 2022 -
Fig. 7 HBV induces GP73 expression to repress the expression of NF-kappaB, IFN-beta, IFN-lambda1, IL-6, and TNF-alpha. The plasmid pHBV1.3 was transfected into HepG2 and Huh7 cells at different doses. After 48 h, the expression levels of GP73, NF-kappaB, IFN-beta, IFN-lambda1, IL-6, and TNF-alpha were detected by qRT-PCR ( A-E ) and Western blotting ( F ). The graphs show the means +- SDs, n = 3. * P < 0.05... View More
Product Details
MA5-30682
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
001
Immunogen
Recombinant Human IL-29 Protein (Met1-Thr200)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786377
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human IL-29.
Target Information
IFN-lambdas constitute a novel family of interferons that mediate the induction of anti-viral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known as IL-29, IL-28A, and IL-28B, respectively. Similar to type I IFNs, IFN-lambdas activate an intracellular signaling to promote gene expression. IFN-lambdas mediate their anti-viral protection through a class II cytokine receptor complex composed of two essential receptor proteins, CRF2-12/IFN-lambdaR1, which is unique to IFN-lambdas, and CFR2-4/IL-10R2, which is shared with IL-10, IL-22, and IL-26 receptors. The IFN-lambdas, IL-28 and IL-29, have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. DCs that differentiate in response to IFN-lambdas express high levels of class I and II MHC gene products, but low levels of costimulatory molecules. Moreover, these cells can specifically induce IL-2-dependent proliferation of CD4+CD25+FOXP3+ T cells with contact-dependent suppressive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytokine Zcyto21; FNL1; IFN lambda1; IFN-lambda-1; IL-29; ILN; Interferon lambda-1; Interferon lambda1; interferon, lambda 1; interferon-lambda-1; Interleukin; interleukin 29 (interferon, lambda 1); Interleukin-29
Gene Aliases: IFNL1; IL-29; IL29; ZCYTO21
UniProt ID: (Human) Q8IU54
Entrez Gene ID: (Human) 282618
negative regulation of type 2 immune response
JAK-STAT cascade
negative regulation of cell proliferation
negative regulation of interleukin-13 production
negative regulation of interleukin-5 production
positive regulation of interferon-gamma production
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of memory T cell differentiation
innate immune response
positive regulation of MHC class I biosynthetic process
negative regulation of T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of JAK-STAT cascade
positive regulation of immune response
defense response to virus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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