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IL-6 Antibody (PP690) in IHC (F)
Frontiers in endocrinology 2013 -
Figure 5 IL-6 and IL-8 expression in the spleen of a dolphin with hyperinsulinemia . Dolphin splenic tissue sections were incubated with primary anti-porcine IL-6 or anti-dolphin IL-8, followed by anti-dolphin CD2, and nuclear staining using VECTASHIELD mounting medium with DAPI. Original magnification 20x.
Product Details
PP690
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Pig
Published species
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant porcine IL-6
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_223541
Product Specific Information
PP690 targets IL-6 in WB applications and shows reactivity with Porcine samples.
The PP690 immunogen is recombinant porcine IL-6.
PP690 detects IL-6 which has a predicted molecular weight of approximately 21 kDa.
This product is a Low Endotoxin formulation.
This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).
Target Information
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytokine; H-IL-6; IL-6; ILN; Interleukin; interleukin 6 (interferon, beta 2); Interleukin-6; interleukin-6 protein; Interleukin6; M-IL-6; R-IL-6
Gene Aliases: IL6
UniProt ID: (Pig) P26893
Entrez Gene ID: (Pig) 399500
acute-phase response
vascular endothelial growth factor production
response to activity
glucose homeostasis
regulation of insulin secretion
regulation of glucagon secretion
interleukin-6-mediated signaling pathway
T-helper 17 cell lineage commitment
hepatocyte proliferation
liver regeneration
positive regulation of STAT cascade
positive regulation of estradiol secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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