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Invitrogen
IL-6 Receptor Polyclonal Antibody
FIGURE: 1 / 3
IL-6 Receptor Antibody (PA5-47209) in IHC (F)
Immunohistochemical analysis of IL-6 Receptor in perfusion fixed frozen sections of mouse thymus. Samples were incubated in IL-6 Receptor polyclonal antibody (Product # PA5-47209) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodi... View More
Product Details
PA5-47209
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse IL-6 R alpha Leu20-Glu357
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609193
Product Specific Information
In sandwich ELISAs, less than 0.3% cross-reactivity with recombinant mouse (rm) IL-6, recombinant human IL-6 R and rmgp130 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD126; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; ILN; Interleukin; Interleukin-6 receptor subunit alpha; MGC104991
Gene Aliases: CD126; IL-6R; Il6r; Il6ra
UniProt ID: (Mouse) P22272
Entrez Gene ID: (Mouse) 16194
positive regulation of cell proliferation
positive regulation of activation of Janus kinase activity
cell growth
cytokine-mediated signaling pathway
endocrine pancreas development
positive regulation of chemokine production
positive regulation of interleukin-6 production
negative regulation of collagen biosynthetic process
response to cytokine
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
positive regulation of JAK-STAT cascade
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
interleukin-6-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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