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Invitrogen
IL-6 Receptor (CD126) Chimeric Recombinant Rabbit Monoclonal Antibody (D7715A7)
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IL-6 Receptor (CD126) Chimeric Antibody (MA5-48200) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of IL-6 Receptor (CD126) in mouse splenocytes using IL-6 Receptor (CD126) Chimeric Monoclonal Antibody (Product # MA5-48200). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with IL-6 Receptor (CD126) Chimeric Monoclonal Antibody at 10 µg/mL followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane staining. The nuclea... View More
Product Details
MA5-48200
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
D7715A7
Immunogen
This antibody was raised by immunising Lewis rats with OKT4 cells.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3074643
Product Specific Information
Specificity: This antibody is specific for murine IL-6R.
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD126; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; ILN; Interleukin; Interleukin-6 receptor subunit alpha; MGC104991
Gene Aliases: CD126; IL-6R; Il6r; Il6ra
UniProt ID: (Mouse) P22272
Entrez Gene ID: (Mouse) 16194
positive regulation of cell proliferation
positive regulation of activation of Janus kinase activity
cell growth
cytokine-mediated signaling pathway
endocrine pancreas development
positive regulation of chemokine production
positive regulation of interleukin-6 production
negative regulation of collagen biosynthetic process
response to cytokine
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
positive regulation of JAK-STAT cascade
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
interleukin-6-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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