Proteintech

IL-6R Polyclonal Antibody

IL-6R Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

IL-6R Antibody (23457-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using (Product # 23457-1-AP) (IL-6R antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

IL-6R Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

23457-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IL-6R Fusion Protein Ag18263 (22-371 aa encoded by BC132684)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQDSS SVPLPTFLVA G (22-371 aa encoded by BC132684)

Target Information

Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.

Oral diseases

Liu C,Zhou J,Zhang S,Fu J,Li Y,Hao Y,Yuan J,Tang F,Ge W,He H,Chen Q

Tue May 30 00:00:00 EDT 2023

Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.

Oral diseases

Liu C,Zhou J,Zhang S,Fu J,Li Y,Hao Y,Yuan J,Tang F,Ge W,He H,Chen Q

Tue May 30 00:00:00 EDT 2023

Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.

Frontiers in cardiovascular medicine

Xu L,Zeng Z,Niu C,Liu D,Lin S,Liu X,Szabó G,Lu J,Zheng S,Zhou P

Tue Apr 04 00:00:00 EDT 2023

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.

Journal of nanobiotechnology

Sha X,Dai Y,Chong L,Wei M,Xing M,Zhang C,Li J

Thu Dec 01 00:00:00 EST 2022

Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma.

Allergology international : official journal of the Japanese Society of Allergology

Chen S,Chen Z,Deng Y,Zha S,Yu L,Li D,Liang Z,Yang K,Liu S,Chen R

Sat Jan 01 00:00:00 EST 2022

Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis.

Signal transduction and targeted therapy

Jin Y,Kang Y,Wang M,Wu B,Su B,Yin H,Tang Y,Li Q,Wei W,Mei Q,Hu G,Lukacs-Kornek V,Li J,Wu K,Yuan X,Wang W

Wed Feb 23 00:00:00 EST 2022

Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin.

Pharmacological research

Wang L,Zhang T,Liu S,Mo Q,Jiang N,Chen Q,Yang J,Han YW,Chen JP,Huang FH,Li H,Zhou J,Luo JS,Wu JM

Tue Mar 01 00:00:00 EST 2022

Cancer cell intrinsic TIM-3 induces glioblastoma progression.

iScience

Guo Q,Shen S,Guan G,Zhu C,Zou C,Cao J,Cheng W,Xu X,Yu J,Lin Z,Wang G,Chen L,Cheng P,Wu A

Fri Nov 18 00:00:00 EST 2022

Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.

Cell proliferation

Huo Y,Yang J,Zheng J,Xu D,Yang M,Tao L,Yao H,Fu X,Yang J,Liu D,Hua R,Zhang J,Sun Y,Hu L,Liu W

Sun May 01 00:00:00 EDT 2022

Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.

Cell proliferation

Huo Y,Yang J,Zheng J,Xu D,Yang M,Tao L,Yao H,Fu X,Yang J,Liu D,Hua R,Zhang J,Sun Y,Hu L,Liu W

Sun May 01 00:00:00 EDT 2022

Ethanol extracts of Rhaponticum uniflorum (L.) DC inflorescence ameliorate LPS-mediated acute lung injury by alleviating inflammatory responses via the Nrf2/HO-1 signaling pathway.

Journal of ethnopharmacology

Zhen D,Liu C,Huang T,Fu D,Bai X,Ma Q,Jiang M,Gong G

Wed Oct 05 00:00:00 EDT 2022

Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation.

Cancer discovery

Du W,Hua F,Li X,Zhang J,Li S,Wang W,Zhou J,Wang W,Liao P,Yan Y,Li G,Wei S,Grove S,Vatan L,Zgodziński W,Majewski M,Wallner G,Chen H,Kryczek I,Fang JY,Zou W

Thu Jul 01 00:00:00 EDT 2021

Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.

Food & function

Zhang Z,Xue Z,Yang H,Zhao F,Liu C,Chen J,Lu S,Zou Z,Zhou Y,Zhang X

Mon Mar 01 00:00:00 EST 2021

Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells.

Molecular vision

Jun L,Lin-Lin S,Hui S

Fri Dec 31 00:00:00 EST 2021

Gelsolin Governs the Neuroendocrine Transdifferentiation of Prostate Cancer Cells and Suppresses the Apoptotic Machinery.

Anticancer research

Oelrich F,Junker H,Stope MB,Erb HHH,Walther R,Venz S,Zimmermann U

Sun Aug 01 00:00:00 EDT 2021

MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.

The Kaohsiung journal of medical sciences

Yang QY,Yang KP,Li ZZ

Wed Jan 01 00:00:00 EST 2020

MicroRNA-34a deficiency leads to impaired wound closure by augmented inflammation in mice.

Annals of translational medicine

Zhao N,Wang G,Long S,Hu M,Gao J,Ran X,Wang J,Su Y,Wang T

Wed Apr 01 00:00:00 EDT 2020

Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma.

Frontiers in oncology

Zhang Z,Sun C,Li C,Jiao X,Griffin BB,Dongol S,Wu H,Zhang C,Cao W,Dong R,Yang X,Zhang Q,Kong B

Mon Sep 28 00:00:00 EDT 2020

Human cancer cells suppress behaviors of endothelial progenitor cells through miR-21 targeting IL6R.

Microvascular research

Wang W,Yuan X,Xu A,Zhu X,Zhan Y,Wang S,Liu M

Thu Nov 01 00:00:00 EDT 2018

Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor.

The Journal of biological chemistry

Zhou Y,Xia Z,Cheng Z,Xu G,Yang X,Liu S,Zhu Y

Fri Nov 23 00:00:00 EST 2018

Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor.

The Journal of biological chemistry

Zhou Y,Xia Z,Cheng Z,Xu G,Yang X,Liu S,Zhu Y

Fri Nov 23 00:00:00 EST 2018

Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-κB, P38 MAPK and STAT3 pathways.

Oncogenesis

Yang X,Shi B,Li L,Xu Z,Ge Y,Shi J,Liu Y,Zheng D

Mon Mar 07 00:00:00 EST 2016

Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-κB, P38 MAPK and STAT3 pathways.

Oncogenesis

Yang X,Shi B,Li L,Xu Z,Ge Y,Shi J,Liu Y,Zheng D

Mon Mar 07 00:00:00 EST 2016

Bioinformatics

Protein Aliases: CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; ILN; Interleukin; interleukin 6 receptor, alpha; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991

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Gene Aliases: CD126; gp80; IL-6R; IL-6R-1; IL-6RA; IL6Q; IL6R; IL6R1; IL6RA; IL6RQ

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UniProt ID: (Human) P08887, (Mouse) P22272

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Entrez Gene ID: (Human) 3570, (Rat) 24499, (Mouse) 16194

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Function(s)

ciliary neurotrophic factor receptor activity interleukin-6 receptor activity interleukin-6 receptor binding protein binding enzyme binding interleukin-6 binding protein homodimerization activity ciliary neurotrophic factor binding cytokine receptor activity transmembrane signal receptor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IL-6R Polyclonal Antibody

IL-6R Antibody (23457-1-AP) in IHC (P)

Product Details

23457-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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