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Product Details
MA5-30922
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
022
Immunogen
Recombinant Human IL7/IL-7/Interleukin-7 Protein (Asp26-His177)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786593
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human IL7/IL-7/Interleukin-7.
Target Information
Interleukin 7 (IL-7) is a hematopoietic cytokine that is constitutively produced by stromal cells from the bone marrow and thymus. IL-7 signals through the IL-7R to promote the differentiation of hematopoietic stem cells to lymphoid precursor cells, which give rise to T cells, B cells, and natural killer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD127; CD127 antigen; CDw127; H-IL-7; IL-7; IL-7 receptor subunit alpha; IL-7R subunit alpha; ILN; Interleukin; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; Interleukin-7; Interleukin-7 receptor subunit alpha; Interleukin7; M-IL-7
Gene Aliases: CD127; CDW127; IL-7; IL-7R-alpha; IL7; IL7R; IL7RA; ILRA
UniProt ID: (Human) P13232, (Human) P16871
Entrez Gene ID: (Human) 3574, (Human) 3575
T cell lineage commitment
humoral immune response
cell-cell signaling
positive regulation of cell proliferation
organ morphogenesis
regulation of gene expression
positive regulation of B cell proliferation
negative regulation of apoptotic process
negative regulation of catalytic activity
bone resorption
positive regulation of T cell differentiation
positive regulation of organ growth
homeostasis of number of cells within a tissue
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
regulation of DNA recombination
cell morphogenesis
negative regulation of T cell mediated cytotoxicity
immunoglobulin production
immune response
signal transduction
cell surface receptor signaling pathway
regulation of cell size
positive regulation of gene expression
cell growth
T cell differentiation
positive regulation of T cell differentiation in thymus
interleukin-7-mediated signaling pathway
B cell proliferation
lymph node development
homeostasis of number of cells
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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