Proteintech

IL15RA Polyclonal Antibody

IL15RA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IL15RA Antibody (16744-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 16744-1-AP) (IL-15RA antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

16744-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IL15RA Fusion Protein Ag10151 (1-231 aa encoded by BC107777)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSVEHADIW VKSYSLYSRE RYICNSGFKR KAGTSSLTEC VLNKATNVAH WTTPSLKCIR DPALVHQRPA PPSTVTTAGV TPQPESLSPS GKEPAASSPS SNNTAATTAA IVPGSQLMPS KSPSTGTTEI SSHESSHGTP SQTTAKTWEL TASASHQPPG VYPQGHSDTT VAISTSTVLL CGLSAVSLLA CYLKSRQTPP LASVEMEAME ALPVTWGTSS RDEDLENCSH HL (1-231 aa encoded by BC107777)

Target Information

Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits. IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease.

Nature communications

Ghosh P,Katkar GD,Shimizu C,Kim J,Khandelwal S,Tremoulet AH,Kanegaye JT,Bocchini J,Das S,Burns JC,Sahoo D

Mon May 16 00:00:00 EDT 2022

AI-guided discovery of the invariant host response to viral pandemics.

bioRxiv : the preprint server for biology

Sahoo D,Katkar GD,Khandelwal S,Behroozikhah M,Claire A,Castillo V,Tindle C,Fuller M,Taheri S,Rogers TF,Beutler N,Ramirez SI,Rawlings SA,Pretorius V,Smith DM,Burton DR,Alexander LEC,Duran J,Crotty S,Dan JM,Das S,Ghosh P

Tue Apr 13 00:00:00 EDT 2021

AI-guided discovery of the invariant host response to viral pandemics.

EBioMedicine

Tue Jun 01 00:00:00 EDT 2021

Oxidative stress-induced IL-15 trans-presentation in keratinocytes contributes to CD8⁺ T cells activation via JAK-STAT pathway in vitiligo.

Free radical biology & medicine

Chen X,Guo W,Chang Y,Chen J,Kang P,Yi X,Cui T,Guo S,Xiao Q,Jian Z,Li K,Gao T,Li S,Liu L,Li C

Thu Aug 01 00:00:00 EDT 2019

Oxidative stress-induced IL-15 trans-presentation in keratinocytes contributes to CD8⁺ T cells activation via JAK-STAT pathway in vitiligo.

Free radical biology & medicine

Chen X,Guo W,Chang Y,Chen J,Kang P,Yi X,Cui T,Guo S,Xiao Q,Jian Z,Li K,Gao T,Li S,Liu L,Li C

Thu Aug 01 00:00:00 EDT 2019

HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis.

Clinical science (London, England : 1979)

Li J,Zeng C,Zheng B,Liu C,Tang M,Jiang Y,Chang Y,Song W,Wang Y,Yang C

Thu Aug 16 00:00:00 EDT 2018

HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis.

Clinical science (London, England : 1979)

Li J,Zeng C,Zheng B,Liu C,Tang M,Jiang Y,Chang Y,Song W,Wang Y,Yang C

Thu Aug 16 00:00:00 EDT 2018

Human Gastric Cancer Mesenchymal Stem Cell-Derived IL15 Contributes to Tumor Cell Epithelial-Mesenchymal Transition via Upregulation Tregs Ratio and PD-1 Expression in CD4⁺T Cell.

Stem cells and development

Sun L,Wang Q,Chen B,Zhao Y,Shen B,Wang X,Zhu M,Li Z,Zhao X,Xu C,Chen Z,Wang M,Xu W,Zhu W

Sat Sep 01 00:00:00 EDT 2018

Human Gastric Cancer Mesenchymal Stem Cell-Derived IL15 Contributes to Tumor Cell Epithelial-Mesenchymal Transition via Upregulation Tregs Ratio and PD-1 Expression in CD4⁺T Cell.

Stem cells and development

Sun L,Wang Q,Chen B,Zhao Y,Shen B,Wang X,Zhu M,Li Z,Zhao X,Xu C,Chen Z,Wang M,Xu W,Zhu W

Sat Sep 01 00:00:00 EDT 2018

Interleukin-15 receptor α expression in inflammatory bowel disease patients before and after normalization of inflammation with infliximab.

Immunology

Perrier C,Arijs I,Staelens D,Breynaert C,Cleynen I,Covens K,Ferrante M,Van Assche G,Vermeire S,de Hertogh G,Schuit F,Rutgeerts P,Ceuppens JL

Tue Jan 01 00:00:00 EST 2013

Interleukin-15 receptor α expression in inflammatory bowel disease patients before and after normalization of inflammation with infliximab.

Immunology

Perrier C,Arijs I,Staelens D,Breynaert C,Cleynen I,Covens K,Ferrante M,Van Assche G,Vermeire S,de Hertogh G,Schuit F,Rutgeerts P,Ceuppens JL

Tue Jan 01 00:00:00 EST 2013

Bioinformatics

Protein Aliases: CD215; IL 15 receptor; IL 15 receptor subunit α; IL 15R; IL 15R alpha; IL 15R α; IL-15 receptor subunit alpha; IL15 receptor; IL15 receptor subunit alpha; IL15 receptor subunit α; IL15R; IL15R alpha; IL15R α; Interleukin 15 receptor; interleukin 15 receptor alpha isoform EM2; interleukin 15 receptor alpha isoform IC2; interleukin 15 receptor alpha isoform IC3; interleukin 15 receptor alpha isoform IC4; interleukin 15 receptor alpha isoform IC5; interleukin 15 receptor alpha isoform IC6; interleukin 15 receptor alpha isoform IC7; interleukin 15 receptor alpha isoform IC8; Interleukin 15 receptor subunit α; interleukin 15 receptor, alpha; Interleukin-15 receptor subunit alpha; sIL 15R; sIL-15R-alpha; sIL-15RA; sIL15R; soluble IL 15R; soluble IL15R

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Gene Aliases: CD215; IL15RA

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UniProt ID: (Human) Q6B0J2

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Entrez Gene ID: (Human) 3601

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Function(s)

signal transducer activity cytokine receptor activity protein binding transmembrane signal receptor

Process(es)

signal transduction cell proliferation cytokine-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IL15RA Polyclonal Antibody

IL15RA Antibody (16744-1-AP) in IHC (P)

Product Details

16744-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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