Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
15648-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IL17RC Fusion Protein Ag8190 (1-350 aa encoded by BC006411)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPVPWFLLS LALGRSPVVL SLERLVGPQD ATHCSPGLSC RLWDSDILCL PGDIVPAPGP VLAPTHLQTE LVLRCQKETD CDLCLRVAVH LAVHGHWEEP EDEEKFGGAA DSGVEEPRNA SLQAQVVLSF QAYPTARCVL LEVQVPAALV QFGQSVGSVV YDCFEAALGS EVRIWSYTQP RYEKELNHTQ QLPALPWLNV SADGDNVHLV LNVSEEQHFG LSLYWNQVQG PPKPRWHKNL TGPQIITLNH TDLVPCLCIQ VWPLEPDSVR TNICPFREDP RAHQNLWQAA RLRLLTLQSW LLDAPCSLPA EAALCWRAPG GDPCQPLVPP LSWENVTVDK VLEFPLLKGH P (1-350 aa encoded by BC006411)
Target Information
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IL-17 receptor C; IL-17RL; IL17F receptor; IL17Rhom; Interleukin-17 receptor C; Interleukin-17 receptor homolog; Interleukin-17 receptor-like protein; ZcytoR14
Gene Aliases: 1110025H02Rik; CANDF9; Gm19850; IL-17RC; IL17-RC; IL17-RL; IL17RC; IL17RL; UNQ6118/PRO20040/PRO38901
UniProt ID: (Human) Q8NAC3, (Mouse) Q8K4C2
Entrez Gene ID: (Human) 84818, (Mouse) 171095
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support