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Product Details
PA5-54108
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human IL17RC. Recombinant protein control fragment (Product #RP-90444).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2642688
Product Specific Information
Immunogen sequence: WDSDILCLPG DIVPAPGPVL APTHLQTELV LRCQKETDCD LCLRVAVHLA VHGHWEEPED EEKFGGAADS GVEEPRNASL QAQVVLSFQA YPTARCVLLE VQVPAALVQF GQSVGSVVYD CFEAALGSEV RIWSYTQPRY EKELNH
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 76%.
Target Information
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IL-17 receptor C; IL-17RL; IL17F receptor; IL17Rhom; Interleukin-17 receptor C; Interleukin-17 receptor homolog; Interleukin-17 receptor-like protein; ZcytoR14
Gene Aliases: CANDF9; IL17-RL; IL17RC; IL17RL; UNQ6118/PRO20040/PRO38901
UniProt ID: (Human) Q8NAC3
Entrez Gene ID: (Human) 84818
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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