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IL17RE Antibody (PA5-89747) in WB
Western blot analysis of IL17RE in extracts of various cell lines. Samples were incubated with IL17RE Polyclonal antibody (Product # PA5-89747) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-89747
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 24-260 of human IL17RE (NP_7056131)
Conjugate
Form
Liquid
Concentration
1.98 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805756
Product Specific Information
Immunogen sequence: AGIGFRHLPH WNTRCPLASH TDDSFTGSSA YIPCRTWWAL FSTKPWCVRV WHCSRCLCQH LLSGGSGLQR GLFHLLVQKS KKSSTFKFYR RHKMPAPAQR KLLPRRHLSE KSHHISIPSP DISHKGLRSK RTQPSDPETW ESLPRLDSQR HGGPEFSFDL LPEARAIRVT ISSGPEVSVR LCHQWALECE ELSSPYDVQK IVSGGHTVEL PYEFLLPCLC IEASYLQEDT VRRKKCP; Positive Samples: HT-29, A-549, A-431, Mouse kidney, Mouse thymus; Cellular Location: Cell membrane, Cytoplasm, Single-pass type I membrane protein
Target Information
The interleukin 17 receptor E (IL-17RE) shares limited similarity to the receptor of IL-17A, a ubiquitous type I membrane glycoprotein that with IL-17A plays a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17RE is the functional receptor of IL-17C and has been suggested to mediate mucosal immunity to infection with intestinal pathogens. IL-17C is produced by epithelia in response to bacterial challenge and binds to a receptor complex formed by IL-17RE and IL-17RA on the epithelial cell surface, thereby regulating the immune function of epithelial cells in an autocrine manner.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IL-17 receptor E; Interleukin-17 receptor E
Gene Aliases: AA589509; IL-17RE; IL17RE; Il25r; UNQ3056/PRO9877
UniProt ID: (Human) Q8NFR9, (Mouse) Q8BH06
Entrez Gene ID: (Human) 132014, (Mouse) 57890
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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