Product References
Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Liu P,Zhou Y,Shi J,Wang F,Yang X,Zheng X,Wang Y,He Y,Xie X,Pang X
Sat Jul 01 00:00:00 EDT 2023
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
International immunopharmacology
Chen L,Mao M,Liu D,Liu W,Wang Y,Xie L,Deng Y,Lin Y,Xu Y,Zhong X,Cao W
Wed Mar 01 00:00:00 EST 2023
Growth differentiation factor 15 protects the airway by inhibiting cell pyroptosis in obese asthmatic mice through the phosphoinositide 3-kinase/AKT pathway.
International immunopharmacology
Li N,He F,Shang Y
Thu Jun 01 00:00:00 EDT 2023
DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury.
Biochimica et biophysica acta. Molecular cell research
Zhou Z,Shang L,Zhang Q,Hu X,Huang JF,Xiong K
Wed Mar 01 00:00:00 EST 2023
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
International immunopharmacology
Dong C,Song C,He Z,Song Q,Song T,Liu J,Xiong Y,Su X,Zhou J,Yang S,Liao W
Sat Apr 01 00:00:00 EDT 2023
Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.
BMC complementary medicine and therapies
Guan X,Shen S,Liu J,Song H,Chang J,Mao X,Song J,Zhang L,Liu C
Mon Mar 06 00:00:00 EST 2023
Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model.
European journal of pharmacology
Cao H,Yang D,Nie K,Lin R,Peng L,Zhou X,Zhang M,Zeng Y,Liu L,Huang W
Sat Aug 05 00:00:00 EDT 2023
HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.
Neuroscience
Zhong X,Wang Y,Liu D,Liang Y,Liu W,Huang Y,Xie L,Cao W,Xu Y,Chen L
Mon May 01 00:00:00 EDT 2023
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Experimental biology and medicine (Maywood, N.J.)
Wang W,Gu Y,Ni H,Quan Q,Guo L
Thu Jun 01 00:00:00 EDT 2023
Achyranthoside D attenuates chondrocyte loss and inflammation in osteoarthritis via targeted regulation of Wnt3a.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Xie W,Qi S,Dou L,Wang L,Wang X,Bi R,Li N,Zhang Y
Wed Mar 01 00:00:00 EST 2023
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.
Science signaling
Jiang B,Wang S,Song G,Jiang Q,Fan M,Fang C,Li X,Soh CL,Manes TD,Cheru N,Qin L,Ren P,Jortner B,Wang Q,Quaranta E,Yoo P,Geirsson A,Davis RP,Tellides G,Pober JS,Jane-Wit D
Tue Mar 21 00:00:00 EDT 2023
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Song D,Zhang A,Hu X,Zeng M,Zhou H
Tue Jul 25 00:00:00 EDT 2023
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Song D,Zhang A,Hu X,Zeng M,Zhou H
Tue Jul 25 00:00:00 EDT 2023
Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy.
Neural regeneration research
Xu XX,Shi RX,Fu Y,Wang JL,Tong X,Zhang SQ,Wang N,Li MX,Tong Y,Wang W,He M,Liu BY,Chen GL,Guo F
Thu Jun 01 00:00:00 EDT 2023
Salmonella typhimurium exacerbates injuries but resolves fibrosis in liver and spleen during Schistosoma mansoni infection.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Lam HYP,Wu WJ,Liang TR,Li HC,Chang KC,Peng SY
Thu Jun 01 00:00:00 EDT 2023
RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition.
Experimental neurology
Fan W,Qin Y,Tan J,Li B,Liu Y,Rong J,Shi W,Yu B
Sun Jan 01 00:00:00 EST 2023
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223-3p/NLRP3 axis.
Ecotoxicology and environmental safety
Hou L,Zhu Z,Jiang F,Zhao J,Jia Q,Jiang Q,Wang H,Xue W,Wang Y,Tian L
Wed Feb 01 00:00:00 EST 2023
Yi-Qi-Jian-Pi formula inhibits hepatocyte pyroptosis through the IDH2-driven tricarboxylic acid cycle to reduce liver injury in acute-on-chronic liver failure.
Journal of ethnopharmacology
Zhao R,Zhao Q,Wang X,Chen X,Liang C,Xiao Q,Yang S,Tan S
Tue Dec 05 00:00:00 EST 2023
Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3/caspase-1 signaling pathway.
Annals of medicine
Wu S,Wen F,Zhong X,Du W,Chen M,Wang J
Fri Dec 01 00:00:00 EST 2023
Melatonin inhibits atherosclerosis progression via galectin-3 downregulation to enhance autophagy and inhibit inflammation.
Journal of pineal research
Wang Z,Gao Z,Zheng Y,Kou J,Song D,Yu X,Dong B,Chen T,Yang Y,Gao X,Wang Q,Ye T,Yang W,Zhang X,Li H,Yang L
Sat Apr 01 00:00:00 EDT 2023
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Journal of agricultural and food chemistry
Tian Y,Feng X,Zhou Z,Qin S,Chen S,Zhao J,Hou J,Liu D
Wed Jan 25 00:00:00 EST 2023
Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B.
Nutrients
Lam HYP,Liang TR,Peng SY
Sat Apr 15 00:00:00 EDT 2023
The expression of cyclic GMP-AMP synthase in human apical periodontitis: A laboratory investigation.
International endodontic journal
Yang F,Liu L,Wang L,Ji X,Zeng Y,Du J,Zhang L,Huang D
Thu Jun 01 00:00:00 EDT 2023
STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease.
Cellular signalling
Yang X,Chen Z,Luo Z,Yang D,Hao Y,Hu J,Feng J,Zhu Z,Luo Q,Zhang Z,Liang W,Ding G
Fri Sep 01 00:00:00 EDT 2023
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
Frontiers in cellular neuroscience
An JR,Liu JT,Gao XM,Wang QF,Sun GY,Su JN,Zhang C,Yu JX,Yang YF,Shi Y
Mon Jun 19 00:00:00 EDT 2023
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Frontiers in cardiovascular medicine
Xu L,Zeng Z,Niu C,Liu D,Lin S,Liu X,Szabó G,Lu J,Zheng S,Zhou P
Tue Apr 04 00:00:00 EDT 2023
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Frontiers in cardiovascular medicine
Xu L,Zeng Z,Niu C,Liu D,Lin S,Liu X,Szabó G,Lu J,Zheng S,Zhou P
Tue Apr 04 00:00:00 EDT 2023
Alternate-day fasting for the protection of cognitive impairment in c57BL/6J mice following whole-brain radiotherapy.
Neurochemistry international
Wu Q,Yu M,Wang Z,Ai X,Liu Z,Zeng J,Li C,Yuan L,He J,Lin X,Wan W
Sun Jan 01 00:00:00 EST 2023
LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis.
Korean circulation journal
He W,Duan L,Zhang L
Thu Jun 01 00:00:00 EDT 2023
CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice.
Brain, behavior, and immunity
Li J,Wang H,Liu D,Li X,He L,Pan J,Shen Q,Peng Y
Mon May 01 00:00:00 EDT 2023
Aristolochic acid I exposure triggers ovarian dysfunction by activating NLRP3 inflammasome and affecting mitochondrial homeostasis.
Free radical biology & medicine
Sun MX,Qiao FX,Xu ZR,Liu YC,Xu CL,Wang HL,Qi ZQ,Liu Y
Tue Aug 01 00:00:00 EDT 2023
Combined exposure to lead and high-fat diet induced neuronal deficits in rats: Anti-neuroinflammatory role of SIRT1.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Liu M,Liu R,Yang M,Ba Y,Deng Q,Zhang Y,Han L,Gao L,Huang H
Sat Jul 01 00:00:00 EDT 2023
Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.
Andrology
Chen Y,Wang L,Huang ZS,Feng JX,Li SX,Du ZJ,Zhang ZB,Liu J,Yang J,Hu ZM,Wang ZL,Chen J
Wed Mar 01 00:00:00 EST 2023
Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats.
BMC neuroscience
Zhou J,Zhang C,Fang X,Zhang N,Zhang X,Zhu Z
Sat Jan 28 00:00:00 EST 2023
NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.
Frontiers in endocrinology
Luo C,Peng Y,Zhou X,Fan J,Chen W,Zhang H,Wei A
Tue Aug 09 00:00:00 EDT 2022
Bioglass promotes wound healing by inhibiting endothelial cell pyroptosis through regulation of the connexin 43/reactive oxygen species (ROS) signaling pathway.
Laboratory investigation; a journal of technical methods and pathology
Zhang K,Chai B,Ji H,Chen L,Ma Y,Zhu L,Xu J,Wu Y,Lan Y,Li H,Feng Z,Xiao J,Zhang H,Xu K
Sat Jan 01 00:00:00 EST 2022
Qingchang Wenzhong Decoction Prevents the Occurrence of Intestinal Tumors by Regulating Intestinal Microbiota and Gasdermin E.
Frontiers in physiology
Ren L,Zhang Z,Zhao W,Zhao B,Chen X,Wang Y,Chen Z,Ye J,Yang Y,Cao P
Tue Aug 02 00:00:00 EDT 2022
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
International journal for parasitology
Lam HYP,Cheng PC,Peng SY
Fri Apr 01 00:00:00 EDT 2022
ATP6AP2 knockdown in cardiomyocyte deteriorates heart function via compromising autophagic flux and NLRP3 inflammasome activation.
Cell death discovery
Li L,Cui YJ,Liu Y,Li HX,Su YD,Li SN,Wang LL,Zhao YW,Wang SX,Yan F,Dong B
Mon Apr 04 00:00:00 EDT 2022
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
Free radical biology & medicine
Wang F,Liang Q,Ma Y,Sun M,Li T,Lin L,Sun Z,Duan J
Tue Mar 01 00:00:00 EST 2022
Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats.
Frontiers in bioscience (Landmark edition)
Xiao Q,Kang Z,Liu C,Tang B
Thu Nov 03 00:00:00 EDT 2022
linc00174 deteriorates the pathogenesis of diabetic retinopathy via miR-26a-5p/PTEN/Akt signalling cascade-mediated pyroptosis.
Biochemical and biophysical research communications
Wang JJ,Chen ZL,Wang DD,Wu KF,Huang WB,Zhang LQ
Sat Nov 19 00:00:00 EST 2022
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
International immunopharmacology
Long Q,Li L,Yang H,Lu Y,Yang H,Zhu Y,Tang Y,Liu C,Yuan J
Thu Sep 01 00:00:00 EDT 2022
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
International immunopharmacology
Long Q,Li L,Yang H,Lu Y,Yang H,Zhu Y,Tang Y,Liu C,Yuan J
Thu Sep 01 00:00:00 EDT 2022
Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via BNIP3/LC3 signaling mediated autophagy.
Brain research bulletin
Luo J,Tan J,Jiang N,Yang C,Chen J,Zhao J,Li L,Zhao Y
Tue Mar 01 00:00:00 EST 2022
Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome.
Acta pharmacologica Sinica
Fu H,Shen QR,Zhao Y,Ni M,Zhou CC,Chen JK,Chi C,Li DJ,Liang G,Shen FM
Sat Oct 01 00:00:00 EDT 2022
Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p.
Frontiers in pharmacology
Song JJ,Li H,Wang N,Zhou XY,Liu Y,Zhang Z,Feng Q,Chen YL,Liu D,Liang J,Ma XY,Wen XR,Fu YY
Tue Dec 27 00:00:00 EST 2022
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Journal of neurotrauma
Zhou Z,Li C,Bao T,Zhao X,Xiong W,Luo C,Yin G,Fan J
Mon Aug 01 00:00:00 EDT 2022
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Journal of neurotrauma
Zhou Z,Li C,Bao T,Zhao X,Xiong W,Luo C,Yin G,Fan J
Mon Aug 01 00:00:00 EDT 2022
Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome.
BMC anesthesiology
Zheng X,Gong T,Tang C,Zhong Y,Shi L,Fang X,Chen D,Zhu Z
Thu Dec 01 00:00:00 EST 2022
α1 -Adrenoceptors activate the NLRP3 inflammasome through downregulation of Kir2.1 in cardiac inflammation.
Experimental physiology
Chen L,Wang W,Peng X,Liu L,Zhang A,Li X,Ma K,Wang L
Wed Jun 01 00:00:00 EDT 2022
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Biochemical and biophysical research communications
Han N,Wang Z,Luo H,Chi Y,Zhang T,Wang B,Li Y
Sat Jun 25 00:00:00 EDT 2022
P2X7R-NEK7-NLRP3 Inflammasome Activation: A Novel Therapeutic Pathway of Qishen Granule in the Treatment of Acute Myocardial Ischemia.
Journal of inflammation research
Li Y,Sun X,Liu X,Li J,Li X,Wang G,Liu Y,Lu X,Cui L,Shao M,Wang Y,Wang W,Li C
Wed Sep 21 00:00:00 EDT 2022
P2X7R-NEK7-NLRP3 Inflammasome Activation: A Novel Therapeutic Pathway of Qishen Granule in the Treatment of Acute Myocardial Ischemia.
Journal of inflammation research
Li Y,Sun X,Liu X,Li J,Li X,Wang G,Liu Y,Lu X,Cui L,Shao M,Wang Y,Wang W,Li C
Wed Sep 21 00:00:00 EDT 2022
P2X7R-NEK7-NLRP3 Inflammasome Activation: A Novel Therapeutic Pathway of Qishen Granule in the Treatment of Acute Myocardial Ischemia.
Journal of inflammation research
Li Y,Sun X,Liu X,Li J,Li X,Wang G,Liu Y,Lu X,Cui L,Shao M,Wang Y,Wang W,Li C
Wed Sep 21 00:00:00 EDT 2022
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
DNA and cell biology
Tang Q,Liu W,Yang X,Tian Y,Chen J,Hu Y,Fu N
Thu Dec 01 00:00:00 EST 2022
ATG5-Mediated Autophagy May Inhibit Pyroptosis to Ameliorate Oleic Acid-Induced Hepatocyte Steatosis.
DNA and cell biology
Tang Q,Liu W,Yang X,Tian Y,Chen J,Hu Y,Fu N
Thu Dec 01 00:00:00 EST 2022
Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Pekkle Lam HY,Hung MY,Cheng PC,Peng SY
Mon Aug 01 00:00:00 EDT 2022
Sodium Tanshinone IIA Sulfonate Inhibits Vascular Endothelial Cell Pyroptosis via the AMPK Signaling Pathway in Atherosclerosis.
Journal of inflammation research
Zhu J,Chen H,Guo J,Zha C,Lu D
Tue Nov 22 00:00:00 EST 2022
Qishen granule (QSG) exerts cardioprotective effects by inhibiting NLRP3 inflammasome and pyroptosis in myocardial infarction rats.
Journal of ethnopharmacology
Chen X,Li Y,Li J,Liu T,Jiang Q,Hong Y,Wang Q,Li C,Guo D,Wang Y
Tue Mar 01 00:00:00 EST 2022
Esculetin inhibits the pyroptosis of microvascular endothelial cells through NF-κB /NLRP3 signaling pathway.
Archives of biochemistry and biophysics
Ren W,Zhou Q,Yu R,Liu Z,Hu Y
Sun May 15 00:00:00 EDT 2022
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE.
Brain research bulletin
Zhong X,Chen Z,Wang Y,Mao M,Deng Y,Shi M,Xu Y,Chen L,Cao W
Sat Oct 15 00:00:00 EDT 2022
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.
Oxidative medicine and cellular longevity
Liang G,Zeng M,Gao M,Xing W,Jin X,Wang Q,Deng L,Ou H,He Z
Tue Mar 08 00:00:00 EST 2022
Apigenin alleviated PA-induced pyroptosis by activating autophagy in hepatocytes.
Food & function
Meng Z,Zhu B,Gao M,Wang G,Zhou H,Lu J,Guan S
Mon May 23 00:00:00 EDT 2022
Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease.
Drug design, development and therapy
Hu Y,Tang W,Liu W,Hu Z,Pan C
Wed Jun 08 00:00:00 EDT 2022
E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
International journal of molecular sciences
Gao Y,Xiao X,Luo J,Wang J,Peng Q,Zhao J,Jiang N,Zhao Y
Mon Nov 07 00:00:00 EST 2022
Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade.
The journal of pain
Xiang T,Li JH,Su HY,Bai KH,Wang S,Traub RJ,Cao DY
Sat Oct 01 00:00:00 EDT 2022
Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade.
The journal of pain
Xiang T,Li JH,Su HY,Bai KH,Wang S,Traub RJ,Cao DY
Sat Oct 01 00:00:00 EDT 2022
Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade.
The journal of pain
Xiang T,Li JH,Su HY,Bai KH,Wang S,Traub RJ,Cao DY
Sat Oct 01 00:00:00 EDT 2022
Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway.
Frontiers in pharmacology
Chai Y,Cai Y,Fu Y,Wang Y,Zhang Y,Zhang X,Zhu L,Miao M,Yan T
Sat Jul 16 00:00:00 EDT 2022
(-)-Epicatechin Ameliorates Monosodium Urate-Induced Acute Gouty Arthritis Through Inhibiting NLRP3 Inflammasome and the NF-κB Signaling Pathway.
Frontiers in pharmacology
Wu C,Li F,Zhang X,Xu W,Wang Y,Yao Y,Han Z,Xia D
Sat Jul 16 00:00:00 EDT 2022
Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells.
International immunopharmacology
Yu C,Wang D,Li Q,Tong Y,Yang Z,Wang T
Fri Jul 01 00:00:00 EDT 2022
Astaxanthin attenuates contrast-induced acute kidney injury in rats via ROS/NLRP3 inflammasome.
International urology and nephrology
Song L,Yao S,Zheng D,Xuan Y,Li W
Wed Jun 01 00:00:00 EDT 2022
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Journal of neuroinflammation
Kou L,Chi X,Sun Y,Han C,Wan F,Hu J,Yin S,Wu J,Li Y,Zhou Q,Zou W,Xiong N,Huang J,Xia Y,Wang T
Mon Jun 06 00:00:00 EDT 2022
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Life sciences
Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X
Thu Dec 15 00:00:00 EST 2022
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Life sciences
Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X
Thu Dec 15 00:00:00 EST 2022
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Life sciences
Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X
Thu Dec 15 00:00:00 EST 2022
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Life sciences
Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X
Thu Dec 15 00:00:00 EST 2022
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Life sciences
Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X
Thu Dec 15 00:00:00 EST 2022
NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells.
Life sciences
Chen J,Peng H,Chen C,Wang Y,Sang T,Cai Z,Zhao Q,Chen S,Lin X,Eling T,Wang X
Thu Dec 15 00:00:00 EST 2022
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.
Nature communications
Chiang HY,Lu HH,Sudhakar JN,Chen YW,Shih NS,Weng YT,Shui JW
Tue Feb 15 00:00:00 EST 2022
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhao AN,Yang Z,Wang DD,Shi B,Zhang H,Bai Y,Yan BW,Zhang Y,Wen JK,Wang XL,Qu CB
Tue Nov 01 00:00:00 EDT 2022
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhao AN,Yang Z,Wang DD,Shi B,Zhang H,Bai Y,Yan BW,Zhang Y,Wen JK,Wang XL,Qu CB
Tue Nov 01 00:00:00 EDT 2022
Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhao AN,Yang Z,Wang DD,Shi B,Zhang H,Bai Y,Yan BW,Zhang Y,Wen JK,Wang XL,Qu CB
Tue Nov 01 00:00:00 EDT 2022
Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway.
Journal of experimental & clinical cancer research : CR
Xiao L,Li X,Cao P,Fei W,Zhou H,Tang N,Liu Y
Thu May 05 00:00:00 EDT 2022
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Cancer cell international
Li W,Huang BS,Xiong YY,Yang LJ,Wu LX
Tue Jan 18 00:00:00 EST 2022
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence.
European journal of pharmacology
Shi Y,Zhao L,Wang J,Liu S,Zhang Y,Qin Q
Thu Dec 15 00:00:00 EST 2022
Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway.
Frontiers in pharmacology
Li L,Deng S,Liu M,Yang M,Li J,Liu T,Zhang T,Zhao Y,He M,Wu D,Xu Y
Fri Dec 02 00:00:00 EST 2022
Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro.
Frontiers in pharmacology
Gao G,Fu L,Xu Y,Tao L,Guo T,Fang G,Zhang G,Wang S,Qin T,Luo P,Shen X
Sat Jul 23 00:00:00 EDT 2022
Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro.
Frontiers in pharmacology
Gao G,Fu L,Xu Y,Tao L,Guo T,Fang G,Zhang G,Wang S,Qin T,Luo P,Shen X
Sat Jul 23 00:00:00 EDT 2022
Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro.
Frontiers in pharmacology
Gao G,Fu L,Xu Y,Tao L,Guo T,Fang G,Zhang G,Wang S,Qin T,Luo P,Shen X
Sat Jul 23 00:00:00 EDT 2022
Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy.
Oxidative medicine and cellular longevity
Li S,Dong S,Shi B,Xu Q,Li L,Wang S,Zhang W,Zhong M,Zhu J,Cheng Y,Zhang G,Hu S
Tue May 03 00:00:00 EDT 2022
Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy.
Oxidative medicine and cellular longevity
Li S,Dong S,Shi B,Xu Q,Li L,Wang S,Zhang W,Zhong M,Zhu J,Cheng Y,Zhang G,Hu S
Tue May 03 00:00:00 EDT 2022
Alliin alleviates LPS-induced pyroptosis via promoting mitophagy in THP-1 macrophages and mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Liu M,Lu J,Yang S,Chen Y,Yu J,Guan S
Tue Feb 01 00:00:00 EST 2022
LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes.
Journal of cellular and molecular medicine
Gu J,Shi JZ,Wang YX,Liu L,Wang SB,Sun JT,Shan TK,Wang H,Wang QM,Wang LS
Sun May 01 00:00:00 EDT 2022
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
Frontiers in oncology
Yu J,Tang R,Li J
Wed Oct 19 00:00:00 EDT 2022
miR-142a-3p Enhances FlaA N/C Protection Against Radiation-Mediated Intestinal Injury by Modulating the IRAK1/NF-κB Signaling Pathway.
International journal of radiation oncology, biology, physics
Liu T,Wu DM,Zhang F,Zhang T,He M,Zhao YY,Li J,Li L,Xu Y
Fri Apr 01 00:00:00 EDT 2022
miR-142a-3p Enhances FlaA N/C Protection Against Radiation-Mediated Intestinal Injury by Modulating the IRAK1/NF-κB Signaling Pathway.
International journal of radiation oncology, biology, physics
Liu T,Wu DM,Zhang F,Zhang T,He M,Zhao YY,Li J,Li L,Xu Y
Fri Apr 01 00:00:00 EDT 2022
Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway.
Renal failure
Cai Q,Sun Z,Xu S,Jiao X,Guo S,Li Y,Wu H,Yu X
Thu Dec 01 00:00:00 EST 2022
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Aging and disease
Li D,Liu M,Li Z,Zheng G,Chen A,Zhao L,Yang P,Wei L,Chen Y,Ruan XZ
Tue Jun 01 00:00:00 EDT 2021
Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice.
Aging and disease
Li D,Liu M,Li Z,Zheng G,Chen A,Zhao L,Yang P,Wei L,Chen Y,Ruan XZ
Tue Jun 01 00:00:00 EDT 2021
Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.
Frontiers in aging neuroscience
Cai Y,Chai Y,Fu Y,Wang Y,Zhang Y,Zhang X,Zhu L,Miao M,Yan T
Tue Feb 08 00:00:00 EST 2022
Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production.
Cellular & molecular immunology
Yang G,Song W,Xu J,Postoak JL,Cheng F,Martinez J,Zhang J,Wu L,Van Kaer L
Sun Aug 01 00:00:00 EDT 2021
Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.
Arteriosclerosis, thrombosis, and vascular biology
Jiang Y,Liu H,Yu H,Zhou Y,Zhang J,Xin W,Li Y,He S,Ma C,Zheng X,Zhang L,Zhao X,Wu B,Jiang C,Zhu D
Wed May 05 00:00:00 EDT 2021
Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.
Arteriosclerosis, thrombosis, and vascular biology
Jiang Y,Liu H,Yu H,Zhou Y,Zhang J,Xin W,Li Y,He S,Ma C,Zheng X,Zhang L,Zhao X,Wu B,Jiang C,Zhu D
Wed May 05 00:00:00 EDT 2021
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway.
Hepatobiliary & pancreatic diseases international : HBPD INT
Pu JL,Huang ZT,Luo YH,Mou T,Li TT,Li ZT,Wei XF,Wu ZJ
Sun Aug 01 00:00:00 EDT 2021
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
eLife
Li J,Qin X,Shi J,Wang X,Li T,Xu M,Chen X,Zhao Y,Han J,Piao Y,Zhang W,Qu P,Wang L,Xiang R,Shi Y
Fri Jun 11 00:00:00 EDT 2021
A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.
eLife
Li J,Qin X,Shi J,Wang X,Li T,Xu M,Chen X,Zhao Y,Han J,Piao Y,Zhang W,Qu P,Wang L,Xiang R,Shi Y
Fri Jun 11 00:00:00 EDT 2021
FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice.
Neuroscience letters
Zheng S,Jian D,Gan H,Wang L,Zhao J,Zhai X
Mon Jun 21 00:00:00 EDT 2021
c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
Huang Y,Wang S,Huang F,Zhang Q,Qin B,Liao L,Wang M,Wan H,Yan W,Chen D,Liu F,Jiang B,Ji D,Xia X,Huang J,Xiong K
Sat May 01 00:00:00 EDT 2021
6-Gingerol protects against cerebral ischemia/reperfusion injury by inhibiting NLRP3 inflammasome and apoptosis via TRPV1 / FAF1 complex dissociation-mediated autophagy.
International immunopharmacology
Luo J,Chen J,Yang C,Tan J,Zhao J,Jiang N,Zhao Y
Mon Nov 01 00:00:00 EDT 2021
General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease.
Oxidative medicine and cellular longevity
Lv T,Lu Y,Liu Y,Feng H,Li C,Sheng W,Cui Z,Zhu S,Gu X,Yang Z,Wan Q
Thu May 20 00:00:00 EDT 2021
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Inflammation
Ji Q,Wang L,Liu J,Wu Y,Lv H,Wen Y,Shi L,Qu B,Szentmáry N
Thu Apr 01 00:00:00 EDT 2021
Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis.
Journal of inflammation research
Wang D,Zhan X,Wu R,You Y,Chen W,Duan L
Mon Apr 25 00:00:00 EDT 2022
Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation.
CNS neuroscience & therapeutics
Li Z,Xu H,Xu Y,Lu G,Peng Q,Chen J,Bi R,Li J,Chen S,Li H,Jin H,Hu B
Wed Dec 01 00:00:00 EST 2021
Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.
Journal of neuroinflammation
Huo S,Ren J,Ma Y,Ozathaley A,Yuan W,Ni H,Li D,Liu Z
Fri Nov 26 00:00:00 EST 2021
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Frontiers in pharmacology
Liu X,Xu Y,Cheng S,Zhou X,Zhou F,He P,Hu F,Zhang L,Chen Y,Jia Y
Tue Jul 27 00:00:00 EDT 2021
Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Proceedings of the National Academy of Sciences of the United States of America
Chakravarti D,Lee R,Multani AS,Santoni A,Keith Z,Hsu WH,Chang K,Reyes L,Rashid A,Wu CJ,Li J,Zhang J,Shim HS,Chandra K,Deng P,Spring DJ,Nielsen OH,Riis LB,Mayigegowda KK,Blutt SE,Zhang J,Younes M,DuPont A,Thirumurthi S,Vilar E,Estes MK,Colla S,Shroyer NF,DePinho RA
Tue Jul 20 00:00:00 EDT 2021
Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy.
Journal of advanced research
Meng Q,Li Y,Ji T,Chao Y,Li J,Fu Y,Wang S,Chen Q,Chen W,Huang F,Wang Y,Zhang Q,Wang X,Bian H
Mon Feb 01 00:00:00 EST 2021
Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy.
Journal of advanced research
Meng Q,Li Y,Ji T,Chao Y,Li J,Fu Y,Wang S,Chen Q,Chen W,Huang F,Wang Y,Zhang Q,Wang X,Bian H
Mon Feb 01 00:00:00 EST 2021
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
Frontiers in pharmacology
Zhang KK,Wang H,Qu D,Chen LJ,Wang LB,Li JH,Liu JL,Xu LL,Yoshida JS,Xu JT,Xie XL,Li DR
Wed Mar 10 00:00:00 EST 2021
JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS.
Frontiers in immunology
Chen L,Zhong X,Cao W,Mao M,Li W,Yang H,Li M,Shi M,Zhang Y,Deng Y,Zu X,Liu J
Fri Jul 02 00:00:00 EDT 2021
Ibudilast Attenuates Folic Acid-Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-κB and MAPK Signaling Pathways.
Frontiers in pharmacology
Li X,Zou Y,Fu YY,Xing J,Wang KY,Wan PZ,Wang M,Zhai XY
Wed May 26 00:00:00 EDT 2021
Ibudilast Attenuates Folic Acid-Induced Acute Kidney Injury by Blocking Pyroptosis Through TLR4-Mediated NF-κB and MAPK Signaling Pathways.
Frontiers in pharmacology
Li X,Zou Y,Fu YY,Xing J,Wang KY,Wan PZ,Wang M,Zhai XY
Wed May 26 00:00:00 EDT 2021
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
PLoS neglected tropical diseases
Lam HYP,Liang TR,Peng SY
Tue Jun 01 00:00:00 EDT 2021
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Journal of cellular and molecular medicine
Han M,Li S,Li L
Mon May 24 00:00:00 EDT 2021
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Frontiers in cell and developmental biology
Liu H,Zhang Y,Song W,Sun Y,Jiang Y
Tue Aug 31 00:00:00 EDT 2021
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Frontiers in cell and developmental biology
Liu H,Zhang Y,Song W,Sun Y,Jiang Y
Tue Aug 31 00:00:00 EDT 2021
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Frontiers in cell and developmental biology
Liu H,Zhang Y,Song W,Sun Y,Jiang Y
Tue Aug 31 00:00:00 EDT 2021
Inflammasome components and ADAMTS4 in premature rupture of membranes.
Molecular medicine reports
Zhu J,Ma C,Luan X,Li J,Peng F,Huang L
Mon Feb 01 00:00:00 EST 2021
Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway.
International immunopharmacology
Wang Y,Song Y,Zhong Q,Wu Y,Zhuang J,Qu F,Xu C
Fri Jan 01 00:00:00 EST 2021
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
BioMed research international
Bai Y,Feng Y,Jiang B,Yang Y,Pei Z,Yang Q,Cui Y
Tue Sep 28 00:00:00 EDT 2021
PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma.
Cell death & disease
Xia T,Liu M,Zhao Q,Ouyang J,Xu P,Chen B
Thu Sep 16 00:00:00 EDT 2021
Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney.
Frontiers in surgery
Liu W,Yang D,Shi J,Wen P,Zhang J,Wang Z,Hu B,Shi X,Cao S,Guo W,Zhang S
Wed Dec 15 00:00:00 EST 2021
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
International journal of molecular medicine
Zeng J,Tao J,Xi L,Wang Z,Liu L
Thu Apr 01 00:00:00 EDT 2021
An In-vivo Study into the Effects of Schisandrin B in the Liver, Spleen, Kidney, and Brain of Acute Thioacetamide-intoxicated Mice.
Iranian journal of pharmaceutical research : IJPR
Lam HYP,Hung MY,Liang TR,Peng SY
Thu Feb 24 00:00:00 EST 2022
SET8 mitigates hepatic ischemia/reperfusion injury in mice by suppressing MARK4/NLRP3 inflammasome pathway.
Life sciences
Luo Y,Huang Z,Mou T,Pu J,Li T,Li Z,Yang H,Yan P,Wu Z,Wu Q
Sat May 15 00:00:00 EDT 2021
The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest.
Journal of neuroinflammation
Shao R,Wang X,Xu T,Xia Y,Cui D
Fri Nov 05 00:00:00 EDT 2021
The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest.
Journal of neuroinflammation
Shao R,Wang X,Xu T,Xia Y,Cui D
Fri Nov 05 00:00:00 EDT 2021
Sodium Sulfite-Induced Mast Cell Pyroptosis and Degranulation.
Journal of agricultural and food chemistry
Liu M,Lu J,Chen Y,Shi X,Li Y,Yang S,Yu J,Guan S
Wed Jul 14 00:00:00 EDT 2021
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Chen LJ,Zhi X,Zhang KK,Wang LB,Li JH,Liu JL,Xu LL,Yoshida JS,Xie XL,Wang Q
Mon Feb 01 00:00:00 EST 2021
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Toxicology and applied pharmacology
Tian X,Xue Y,Xie G,Zhou Y,Xiao H,Ding F,Zhang M
Fri Oct 15 00:00:00 EDT 2021
Naringenin prevents TNF-α-induced gut-vascular barrier disruption associated with inhibiting the NF-κB-mediated MLCK/p-MLC and NLRP3 pathways.
Food & function
Zhong J,Yu R,Zhou Q,Liu P,Liu Z,Bian Y
Sun Mar 21 00:00:00 EDT 2021
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Cell death & disease
Wang Y,Chen Q,Jiao F,Shi C,Pei M,Wang L,Gong Z
Mon Jan 11 00:00:00 EST 2021
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Cell death & disease
Wang Y,Chen Q,Jiao F,Shi C,Pei M,Wang L,Gong Z
Mon Jan 11 00:00:00 EST 2021
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Cell death & disease
Wang Y,Chen Q,Jiao F,Shi C,Pei M,Wang L,Gong Z
Mon Jan 11 00:00:00 EST 2021
Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site.
Cell death & disease
Wang Y,Chen Q,Jiao F,Shi C,Pei M,Wang L,Gong Z
Mon Jan 11 00:00:00 EST 2021
Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.
Oxidative medicine and cellular longevity
Zhu JJ,Yu BY,Huang XK,He MZ,Chen BW,Chen TT,Fang HY,Chen SQ,Fu XQ,Li PJ,Lin ZL,Zhu JH
Wed Nov 24 00:00:00 EST 2021
Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway.
International immunopharmacology
Cheng J,Hao J,Jiang X,Ji J,Wu T,Chen X,Zhang F
Fri Oct 01 00:00:00 EDT 2021
The relationship between liver pathological inflammation degree and pyroptosis in chronic hepatitis B patients.
Journal of medical virology
Wang Y,Li X,Chen Q,Jiao F,Shi C,Pei M,Wang L,Gong Z
Mon Nov 01 00:00:00 EDT 2021
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Drug design, development and therapy
Gao Z,Sui J,Fan R,Qu W,Dong X,Sun D
Mon Mar 29 00:00:00 EDT 2021
Autophagy Activation Represses Pyroptosis through the IL-13 and JAK1/STAT1 Pathways in a Mouse Model of Moderate Traumatic Brain Injury.
ACS chemical neuroscience
Gao C,Yan Y,Chen G,Wang T,Luo C,Zhang M,Chen X,Tao L
Wed Dec 16 00:00:00 EST 2020
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Oxidative medicine and cellular longevity
Zhou X,Liu Z,Ying K,Wang H,Liu P,Ji X,Chi T,Zou L,Wang S,He Z
Wed Jan 27 00:00:00 EST 2021
Trimethylamine N-oxide promotes apoE-/- mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway.
Journal of cellular physiology
Wu P,Chen J,Chen J,Tao J,Wu S,Xu G,Wang Z,Wei D,Yin W
Thu Oct 01 00:00:00 EDT 2020
FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity.
Science advances
Ren J,Sun M,Zhou H,Ajoolabady A,Zhou Y,Tao J,Sowers JR,Zhang Y
Tue Sep 01 00:00:00 EDT 2020
NLRP6 contributes to inflammation and brain injury following intracerebral haemorrhage by activating autophagy.
Journal of molecular medicine (Berlin, Germany)
Xiao H,Chen H,Jiang R,Zhang L,Wang L,Gan H,Jiang N,Zhao J,Zhai X,Liang P
Tue Sep 01 00:00:00 EDT 2020
H3 relaxin protects against calcium oxalate crystal-induced renal inflammatory pyroptosis.
Cell proliferation
Liu J,Yang K,Jin Y,Liu Y,Chen Y,Zhang X,Yu S,Song E,Chen S,Zhang J,Jing G,An R
Thu Oct 01 00:00:00 EDT 2020
Telomere dysfunction activates YAP1 to drive tissue inflammation.
Nature communications
Chakravarti D,Hu B,Mao X,Rashid A,Li J,Li J,Liao WT,Whitley EM,Dey P,Hou P,LaBella KA,Chang A,Wang G,Spring DJ,Deng P,Zhao D,Liang X,Lan Z,Lin Y,Sarkar S,Terranova C,Deribe YL,Blutt SE,Okhuysen P,Zhang J,Vilar E,Nielsen OH,Dupont A,Younes M,Patel KR,Shroyer NF,Rai K,Estes MK,Wang YA,Bertuch AA,DePinho RA
Mon Sep 21 00:00:00 EDT 2020
Impact of chitosan membrane culture on the expression of pro- and anti-inflammatory cytokines in mesenchymal stem cells.
Experimental and therapeutic medicine
Yi P,Xu X,Qiu B,Li H
Thu Oct 01 00:00:00 EDT 2020
TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.
Cell proliferation
Wang Y,Zhang H,Chen Q,Jiao F,Shi C,Pei M,Lv J,Zhang H,Wang L,Gong Z
Mon Jun 01 00:00:00 EDT 2020
Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia.
Oxidative medicine and cellular longevity
He XM,Zhou YZ,Sheng S,Li JJ,Wang GQ,Zhang F
Tue Jun 08 00:00:00 EDT 2021
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR.
Cell cycle (Georgetown, Tex.)
Xu Y,Fang H,Xu Q,Xu C,Yang L,Huang C
Sun Nov 01 00:00:00 EDT 2020
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury.
Journal of neuroinflammation
Chang Y,Zhu J,Wang D,Li H,He Y,Liu K,Wang X,Peng Y,Pan S,Huang K
Thu Jul 23 00:00:00 EDT 2020
Angiostrongylus cantonensis activates inflammasomes in meningoencephalitic BALB/c mice.
Parasitology international
Lam HYP,Chen TT,Chen CC,Yang TH,Cheng PC,Peng SY
Sat Aug 01 00:00:00 EDT 2020
Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway.
Neurochemical research
Liu R,Wu S,Guo C,Hu Z,Peng J,Guo K,Zhang X,Li J
Thu Oct 01 00:00:00 EDT 2020
Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway.
Neurochemical research
Liu R,Wu S,Guo C,Hu Z,Peng J,Guo K,Zhang X,Li J
Thu Oct 01 00:00:00 EDT 2020
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
Biomolecules
Lam HYP,Liang TR,Jiang SJ,Peng SY
Sun Jul 05 00:00:00 EDT 2020
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Free radical biology & medicine
Kai J,Yang X,Wang Z,Wang F,Jia Y,Wang S,Tan S,Chen A,Shao J,Zhang F,Zhang Z,Zheng S
Mon Jun 01 00:00:00 EDT 2020
Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice.
British journal of pharmacology
Wang Q,Ou Y,Hu G,Wen C,Yue S,Chen C,Xu L,Xie J,Dai H,Xiao H,Zhang Y,Qi R
Wed Apr 01 00:00:00 EDT 2020
Histone Deacetylation 10 Alleviates Inflammation After Intracerebral Hemorrhage via the PTPN22/NLRP3 Pathway in Rats.
Neuroscience
Wang L,Zheng S,Zhang L,Xiao H,Gan H,Chen H,Zhai X,Liang P,Zhao J,Li Y
Wed Apr 15 00:00:00 EDT 2020
Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis.
Frontiers in pharmacology
Li N,Zhao T,Cao Y,Zhang H,Peng L,Wang Y,Zhou X,Wang Q,Li J,Yan M,Dong X,Zhao H,Li P
Tue Feb 16 00:00:00 EST 2021
Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.
Toxicology
Jia Y,Gao L,Yang X,Zhang F,Chen A,Wang S,Shao J,Tan S,Zheng S
Wed Jul 01 00:00:00 EDT 2020
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice via Its Anti-inflammatory and Antipyroptotic Effects.
BioMed research international
Pei ZW,Guo Y,Zhu HL,Dong M,Zhang Q,Wang F
Tue May 04 00:00:00 EDT 2021
Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.
Inflammation
Zhuang J,Wang Y,Qu F,Wu Y,Zhao D,Xu C
Mon Apr 01 00:00:00 EDT 2019
Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.
Inflammation
Zhuang J,Wang Y,Qu F,Wu Y,Zhao D,Xu C
Mon Apr 01 00:00:00 EDT 2019
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Inflammation
Liu H,Sun Y,Zhang Y,Yang G,Guo L,Zhao Y,Pei Z
Mon Apr 01 00:00:00 EDT 2019
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Inflammation
Liu H,Sun Y,Zhang Y,Yang G,Guo L,Zhao Y,Pei Z
Mon Apr 01 00:00:00 EDT 2019
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Inflammation
Liu H,Sun Y,Zhang Y,Yang G,Guo L,Zhao Y,Pei Z
Mon Apr 01 00:00:00 EDT 2019
Role of Thymoquinone in Cardiac Damage Caused by Sepsis from BALB/c Mice.
Inflammation
Liu H,Sun Y,Zhang Y,Yang G,Guo L,Zhao Y,Pei Z
Mon Apr 01 00:00:00 EDT 2019
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Mediators of inflammation
Leng B,Zhang Y,Liu X,Zhang Z,Liu Y,Wang H,Lu M
Mon Jul 22 00:00:00 EDT 2019
Sorghum Phenolics Inhibits Inflammasomes in Lipopolysaccharide (LPS)-Primed and Adenosine Triphosphate (ATP)-Activated Macrophages.
Plant foods for human nutrition (Dordrecht, Netherlands)
Dia VP,Bradwell J,Pangloli P
Sun Sep 01 00:00:00 EDT 2019
Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway.
Life sciences
Gao S,Xu T,Guo H,Deng Q,Xun C,Liang W,Sheng W
Fri Nov 15 00:00:00 EST 2019
Light-emitting diode therapy protects against ventricular arrhythmias by neuro-immune modulation in myocardial ischemia and reperfusion rat model.
Journal of neuroinflammation
Wang S,Wu L,Li X,Li B,Zhai Y,Zhao D,Jiang H
Mon Jul 08 00:00:00 EDT 2019
Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
Cells
He Q,Li Z,Meng C,Wu J,Zhao Y,Zhao J
Wed Aug 14 00:00:00 EDT 2019
Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E. coli infection.
American journal of physiology. Cell physiology
Wu Z,Li Y,Liu Q,Liu Y,Chen L,Zhao H,Guo H,Zhu K,Zhou N,Chai TC,Shi B
Sun Sep 01 00:00:00 EDT 2019
Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release.
Frontiers in oncology
Tong L,Xie C,Wei Y,Qu Y,Liang H,Zhang Y,Xu T,Qian X,Qiu H,Deng H
Thu Oct 01 00:00:00 EDT 2020
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Frontiers in immunology
Guo Q,Wu Y,Hou Y,Liu Y,Liu T,Zhang H,Fan C,Guan H,Li Y,Shan Z,Teng W
Fri Aug 16 00:00:00 EDT 2019
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Frontiers in immunology
Guo Q,Wu Y,Hou Y,Liu Y,Liu T,Zhang H,Fan C,Guan H,Li Y,Shan Z,Teng W
Fri Aug 16 00:00:00 EDT 2019
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Liu Z,Zhu P,Zhang L,Xiong B,Tao J,Guan W,Li C,Chen C,Gu J,Duanmu J,Zhang W
Sun Jul 01 00:00:00 EDT 2018
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Liu Z,Zhu P,Zhang L,Xiong B,Tao J,Guan W,Li C,Chen C,Gu J,Duanmu J,Zhang W
Sun Jul 01 00:00:00 EDT 2018
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
He W,Ye S,Zeng C,Xue S,Hu X,Zhang X,Gao S,Xiong Y,He X,Vivalda S,Li L,Wang Y,Ye Q
Tue Jun 05 00:00:00 EDT 2018
Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
He W,Ye S,Zeng C,Xue S,Hu X,Zhang X,Gao S,Xiong Y,He X,Vivalda S,Li L,Wang Y,Ye Q
Tue Jun 05 00:00:00 EDT 2018
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Neurochemistry international
Zhang J,Tucker LD,Lu Y,Yang L,Wu C,Li Y,Zhang Q
Fri Jun 01 00:00:00 EDT 2018
Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis.
Redox biology
Han Y,Xu X,Tang C,Gao P,Chen X,Xiong X,Yang M,Yang S,Zhu X,Yuan S,Liu F,Xiao L,Kanwar YS,Sun L
Fri Jun 01 00:00:00 EDT 2018
Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis.
Redox biology
Han Y,Xu X,Tang C,Gao P,Chen X,Xiong X,Yang M,Yang S,Zhu X,Yuan S,Liu F,Xiao L,Kanwar YS,Sun L
Fri Jun 01 00:00:00 EDT 2018
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Scientific reports
Wang Y,Qin Y,Wang T,Chen Y,Lang X,Zheng J,Gao S,Chen S,Zhong X,Mu Y,Wu X,Zhang F,Zhao W,Zhong Z
Tue Feb 13 00:00:00 EST 2018
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Scientific reports
Wang Y,Qin Y,Wang T,Chen Y,Lang X,Zheng J,Gao S,Chen S,Zhong X,Mu Y,Wu X,Zhang F,Zhao W,Zhong Z
Tue Feb 13 00:00:00 EST 2018
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Scientific reports
Wang Y,Qin Y,Wang T,Chen Y,Lang X,Zheng J,Gao S,Chen S,Zhong X,Mu Y,Wu X,Zhang F,Zhao W,Zhong Z
Tue Feb 13 00:00:00 EST 2018
Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response.
Scientific reports
Wang Y,Qin Y,Wang T,Chen Y,Lang X,Zheng J,Gao S,Chen S,Zhong X,Mu Y,Wu X,Zhang F,Zhao W,Zhong Z
Tue Feb 13 00:00:00 EST 2018
Clostridium butyricum regulates visceral hypersensitivity of irritable bowel syndrome by inhibiting colonic mucous low grade inflammation through its action on NLRP6.
Acta biochimica et biophysica Sinica
Zhao K,Yu L,Wang X,He Y,Lu B
Thu Feb 01 00:00:00 EST 2018
Increased expression of NLRP3 inflammasome components and interleukin-18 in patients with bullous pemphigoid.
Journal of dermatological science
Fang H,Shao S,Cao T,Lei J,Dang E,Zhang J,Wang G
Mon Aug 01 00:00:00 EDT 2016
Increased expression of NLRP3 inflammasome components and interleukin-18 in patients with bullous pemphigoid.
Journal of dermatological science
Fang H,Shao S,Cao T,Lei J,Dang E,Zhang J,Wang G
Mon Aug 01 00:00:00 EDT 2016
NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins.
Coronary artery disease
Altaf A,Qu P,Zhao Y,Wang H,Lou D,Niu N
Sat Aug 01 00:00:00 EDT 2015
NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins.
Coronary artery disease
Altaf A,Qu P,Zhao Y,Wang H,Lou D,Niu N
Sat Aug 01 00:00:00 EDT 2015
Schistosoma japonicum scFv-IL18 fusion DNA ameliorates hepatic fibrosis in schistosomiasis-infected mice via improving local concentration of IL-18 in liver.
Experimental parasitology
Tian Z,Wang XY,Zhou YF,Feng QM,Zhang SJ,Yin TQ,Xu SR,Xia YD,Xu J,Jin J,Wang SP
Thu Aug 01 00:00:00 EDT 2013
Schistosoma japonicum scFv-IL18 fusion DNA ameliorates hepatic fibrosis in schistosomiasis-infected mice via improving local concentration of IL-18 in liver.
Experimental parasitology
Tian Z,Wang XY,Zhou YF,Feng QM,Zhang SJ,Yin TQ,Xu SR,Xia YD,Xu J,Jin J,Wang SP
Thu Aug 01 00:00:00 EDT 2013
