Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 1
IL18R1 Antibody (MA5-23855) in Neu
Neutralization of IL18R1 in activated mouse T cells. Samples were incubated in IL18R1 monoclonal antibody (Product # MA5-23855). In the presence of Recombinant Mouse IL‚12 (0.1 ng/mL), Recombinant Mouse IL‚18/IL‚1F4 stimulates IFN‚γ secretion in activated mouse T cells in a dose-dependent manner (orange line), as measured by the Mouse IFN‚γ Quantikine ELISA Kit. Under these conditions, IFN‚γ secretion elicited by Recombinant Mouse IL‚18/IL‚1F4 (0.5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IL‚18 Rα/IL‚1 R5 Mo... View More
Product Details
MA5-23855
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2A
Class
Monoclonal
Type
Antibody
Clone
112624
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse IL-18 R alpha Ser19-Gly326
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607395
Product Specific Information
In direct ELISAs, this antibody does not cross-react with recombinant mouse (rm) IL-1 RI, rmIL-1 RII, rhIL-1 R3, recombinant human (rh) IL-1 R4, rhIL-1 R5, recombinant rat IL-1 R6, rmIL-1 R7, rhIL-1 R8, rhIL-1 R9, or rmSIGIRR.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
IL18R1 is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CD218 antigen-like family member A; CD218a; IL-18R-1; IL-18R-alpha; IL-18R1; IL-1Rrp; IL1 receptor-related protein; IL1R-rp; interleukin 1 receptor related protein; Interleukin-18 receptor 1; Interleukin-18 receptor alpha
Gene Aliases: Il18r1; Il18ralpha; Il1rrp
UniProt ID: (Mouse) Q61098
Entrez Gene ID: (Mouse) 16182
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support